Recombinant tissue factor pathway inhibitor induces apoptosis in cultured rat mesangial cells via its Kunitz-3 domain and C-terminal through inhibiting PI3-kinase/Akt pathway

Apoptosis

Volumn 12, Issue 12, 2007, Pages 2163-2173

  Lin, Yi Feng ^a   Zhang, Nong ^a   Guo, Hong Shen ^a   Kong, De Sheng ^a   Jiang, Tao ^a   Liang, Wang ^a   Zhao, Zhong Hua ^a   Tang, Qi Qun ^a   Ma, Duan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Mesangial cell; PI3 kinase Akt pathway; Recombinant tissue factor pathway inhibitor

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE 3; FAS ANTIGEN; I KAPPA B ALPHA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; IMMUNOFLUORESCENCE; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEIN DOMAIN; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; CASPASE 3; CELL NUCLEUS; CELLS, CULTURED; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLOMERULONEPHRITIS; LIPOPROTEINS; MALE; MESANGIAL CELLS; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBOPLASTIN;

RATTUS;

EID: 35948975680     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0136-y     Document Type: Article

References (47)

1. Takahashi T, Abe H, Arai H et al (2005) Activation of STAT3/Smad1 is a key signaling pathway for progression to glomerulosclerosis in experimental glomerulonephritis. J Biol Chem 280:7100-7106
2. Baker AJ, Mooney A, Hughes J et al (1994) Mesangial cell apoptosis: the major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis. J Clin Invest 94:2105-2116
3. Sugiyama H, Kashihara N, Makino H et al (1996) Apoptosis in glomerular sclerosis. Kidney Int 49:103-111
4. Sandset PM (1996) Tissue factor pathway inhibitor (TFPI)-an update. Haemostasis 26:154-165
5. Hembrough TA, Ruiz JF, Swerdlow BM et al (2004) Identification and characterization of a very low density lipoprotein receptor-binding peptide from tissue factor pathway inhibitor that has antitumor and antiangiogenic activity. Blood 103:3374-3380
6. Kamikubo Y, Nakahara Y, Takemoto S et al (1997) Human recombinant tissue-factor pathway inhibitor prevents the proliferation of cultured human neonatal aortic smooth muscle cells. FEBS Lett 407:116-120
7. Hamuro T, Kamikubo Y, Nakahara Y et al (1998) Human recombinant tissue factor pathway inhibitor induces apoptosis in cultured human endothelial cells. FEBS Lett 421:197-202
8. Hembrough TA, Ruiz JF, Papathanassiu AE et al (2001) Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor. J Biol Chem 276:12241-12248
9. Yamabe H, Osawa H, Inuma H et al (1996) Tissue factor pathway inhibitor production by human mesangial cells in culture. Thromb Haemost 76:215-219
10. Cunningham MA, Ono T, Hewitson TD et al (1999) Tissue factor pathway inhibitor expression in human crescentic glomerulonephritis. Kidney Int 55:1311-1318
11. Erlich JH, Apostolopoulos J, Wun TC et al (1996) Renal expression of tissue factor pathway inhibitor and evidence for a role in crescentic glomerulonephritis in rabbits. J Clin Invest 98:325-335
12. Brachmann SM, Yballe CM, Innocenti M et al (2005) Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement. Mol Cell Biol 25:2593-2606
13. Foster FM, Traer CJ, Abraham SM et al (2003) The phosphoinositide (PI) 3-kinase family. J Cell Sci 116:3037-3040
14. Toker A (2000) Protein kinases as mediators of phosphoinositide 3-kinase signaling. Mol Pharmacol 57:652-658
15. Koyasu S (2003) The role of PI3K in immune cells. Nat Immunol 4:313-319
16. Datta K, Franke TF, Chan TO et al (1995) AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation. Mol Cell Biol 15:2304-2310
17. Kulik G, Klippel A, Weber MJ (1997) Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606
18. Yao R, Cooper GM (1995) Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006
19. Brunet A, Bonni A, Zigmond MJ et al (1999) Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor. Cell 96:857-868
20. Downward J (1998) Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10:262-267
21. Sizemore N, Leung S, Stark GR (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 19:4798-4805
22. Ozes ON, Mayo LD, Gustin JA et al (1999) NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401:82-85
23. Bokemeyer D, Ostendorf T, Kunter U et al (2000) Differential activation of mitogen-activated protein kinases in experimental mesangioproliferative glomerulonephritis. J Am Soc Nephrol 11:232-240
24. Caplice NM, Mueske CS, Kleppe LS et al (1998) Expression of tissue factor pathway inhibitor in vascular smooth muscle cells and its regulation by growth factors. Circ Res 83:1264-1270
25. Petit L, Lesnik P, Dachet C et al (1999) Tissue factor pathway inhibitor is expressed by human monocyte-derived macrophages: relationship to tissue factor induction by cholesterol and oxidized LDL. Arterioscler Thromb Vasc Biol 19:309-315
26. Pendurthi UR, Rao LVM, Williams T et al (1999) Regulation of tissue factor pathway inhibitor expression in smooth muscle cells. Blood 94:579-586
27. Bajaj MS, steer S, Kuppuswamy MN et al (1999) Synthesis and expression of tissue factor pathway inhibitor by serum-stimulated fibroblasts, vascular smooth muscle cells and cardiomyocytes. Thromb Haemost 82:1663-1672
28. Nguyen P, Broussas M, Cornillet-Lefebvre P et al (1999) Coexpression of tissue factor and tissue factor pathway inhibitor by human monocytes purified by leukapheresis and elutriation: response of nonadherent cells to lipopolysaccharide. Transfusion 39:975-982
29. Shimamura H, Terada T, Okado T et al (2003) The PI3-Kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-κB and Bad. J Am Soc Nephrol 14:1427-1434
30. Harlos K, Martin DM, O'Brien DP et al (1994) Crystal structure of the extracellular region of human tissue factor. Nature 370:662-666
31. Lovett DH, Sterzel RB (1986) Cell culture approaches to the analysis of glomerular inflammation. Kidney Int 30:246-254
32. Striker LJ, Peten EP, Elliot SJ et al (1991) Mesangial cell turnover: effect of heparin and peptide growth factors. Lab Invest 64:446-456
33. Mene P, Simonson MS, Dunn MJ (1989) Physiology of the mesangial cell. Physiol Rev 69:1347-1424
34. Abboud HE (1993) Nephrology forum: growth factors in glomerulonephritis. Kidney Int 43:252-267
35. Shimizu A, Kitamura H, Masuda Y et al (1995) Apoptosis in the repair process of experimental proliferative glomerulonephritis. Kidney Int 47:114-121
36. Hembrough TA, Ruiz JF, Papathanassiu AE et al (2001) Tissue factor pathway inhibitor inhibits endothelial cell proliferation via association with the very low density lipoprotein receptor. J Biol Chem 276:12241-12248
37. Singh R, Pan S, Mueske CS et al (2003) Tissue factor pathway inhibitor deficiency enhances neointimal proliferation and formation in a murine model of vascular remodelling. Thromb Haemost 89:747-751
38. Versteeg HH, Peppelenbosch MP, Arnold Spek C (2003) Tissue factor signal transduction in angiogenesis. Carcinogenesis 24:1009-1013
39. Belting M, Dorrell MI, Sandgren S et al (2004) Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 10:502-509
40. Piro O, Broze GJ Jr (2004) Role for the Kunitz-3 domain of tissue factor pathway inhibitor-αin cell surface binding. Circulation 110:3567-3572
41. Kaufmann SH, Hengartner MO (2001) Programmed cell death: alive and well in the new millennium. Trends Cell Biol 11:526-534
42. Nagata S, Golstein P (1995) The fas death factor. Science 267:1449-1456
43. Vander Heiden MG, Chandel NS, Li XX et al (2000) Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc Natl Acad Sci 97:4666-4671
44. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
45. Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
46. Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435-437
47. Brockman JA, Scherer DC, McKinnsey TA et al (1995) Coupling of a signal response domain in IκBα to multiple pathways for NFκB activation. Mol Cell Biol 15:2809-2818