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Volumn 57, Issue 10, 2007, Pages 647-653

Clinical study on the effect of simvastatin on paraoxonase activity

Author keywords

Antioxidants; Aryldialkylphosphatase; CAS 79902 63 9; Cholesterol, high and low density apoprotein; Lipex ; Paraoxonase; Simvastatin, clinical study, effect on paraoxonase activity

Indexed keywords

ANTIOXIDANT; APOLIPOPROTEIN A1; ARYLDIALKYLPHOSPHATASE; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHOTRIESTERASE; SIMVASTATIN; TRIACYLGLYCEROL;

EID: 35948935583     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296663     Document Type: Article
Times cited : (11)

References (44)
  • 2
    • 0344951233 scopus 로고    scopus 로고
    • Opposite Regulation of the Human Paraoxonase-1 Gene PON-1 by Fenofibrate and Statins
    • Gouédard C, Koum-Besson N, Barouki R, Morel Y. Opposite Regulation of the Human Paraoxonase-1 Gene PON-1 by Fenofibrate and Statins. Mol Pharmacol. 2003;63:945-956.
    • (2003) Mol Pharmacol , vol.63 , pp. 945-956
    • Gouédard, C.1    Koum-Besson, N.2    Barouki, R.3    Morel, Y.4
  • 4
    • 0036123993 scopus 로고    scopus 로고
    • Oxidative stress increases the expression of the CD 36 scavenger receptor and cellular uptake of Ox-LDL in macrophages from atherosclerotic mice: Protective role of antioxidants and of paraoxonase
    • Furhman B, Volkova N, Aviram M. Oxidative stress increases the expression of the CD 36 scavenger receptor and cellular uptake of Ox-LDL in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase. Atherosclerosis. 2002;161:307-316.
    • (2002) Atherosclerosis , vol.161 , pp. 307-316
    • Furhman, B.1    Volkova, N.2    Aviram, M.3
  • 5
    • 0034738140 scopus 로고    scopus 로고
    • Human serum paraoxonases1 (PON1), Q and R selectively decrease lipid peroxides in coronary and carotid atherosclerosic lesions: PON1 esterase and peroxidase-like activities
    • Aviram M, Hardak E, Vaya J, Mahmood S, Milo S, Hoffman A, et al. Human serum paraoxonases1 (PON1), Q and R selectively decrease lipid peroxides in coronary and carotid atherosclerosic lesions: PON1 esterase and peroxidase-like activities. Circulation. 2000;101:2510-2517.
    • (2000) Circulation , vol.101 , pp. 2510-2517
    • Aviram, M.1    Hardak, E.2    Vaya, J.3    Mahmood, S.4    Milo, S.5    Hoffman, A.6
  • 6
    • 0037375932 scopus 로고    scopus 로고
    • bin Ali Azhar, Zhang Q, Lim YK, Fang D, Retnam L, Lim SK. Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radic Biol Med. 2003;34:824-829.
    • bin Ali Azhar, Zhang Q, Lim YK, Fang D, Retnam L, Lim SK. Expression of major HDL-associated antioxidant PON-1 is gender dependent and regulated during inflammation. Free Radic Biol Med. 2003;34:824-829.
  • 7
    • 0000261991 scopus 로고
    • the Scandinavian Survival Study
    • Scandinavian Simvastatin Survival Study Group Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease
    • Scandinavian Simvastatin Survival Study Group Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease, the Scandinavian Survival Study. Lancet. 1994;344:1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 8
    • 0036970128 scopus 로고    scopus 로고
    • The role of hypolipemic drugs today
    • Reiner Z. The role of hypolipemic drugs today. Medicus. 2002;11:37-47.
    • (2002) Medicus , vol.11 , pp. 37-47
    • Reiner, Z.1
  • 9
    • 0242721909 scopus 로고    scopus 로고
    • Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase
    • Deakin S, Leviev I, Guernier S, James RW. Simvastatin modulates expression of the PON1 gene and increases serum paraoxonase. Arterioscler Thromb Vasc Biol. 2003;23: 2083-2089.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 2083-2089
    • Deakin, S.1    Leviev, I.2    Guernier, S.3    James, R.W.4
  • 10
    • 0032927137 scopus 로고    scopus 로고
    • Serum paraoxonase activity and phenotype distribution in Turkish subjects with coronary heart disease and its relationship to serum lipids and lipoproteins
    • Karakaya A, Ibis S, Kural T, Kose SK, Karakaya AE. Serum paraoxonase activity and phenotype distribution in Turkish subjects with coronary heart disease and its relationship to serum lipids and lipoproteins. Chem Biol Interact. 1999;118:193-200.
    • (1999) Chem Biol Interact , vol.118 , pp. 193-200
    • Karakaya, A.1    Ibis, S.2    Kural, T.3    Kose, S.K.4    Karakaya, A.E.5
  • 11
    • 0038120009 scopus 로고    scopus 로고
    • Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study
    • Mackness B, Durrington P, McElduff P, Yarnell J, Azam N, Watt M, et al. Low paraoxonase activity predicts coronary events in the Caerphilly Prospective Study. Circulation. 2003;107:2775-2779.
    • (2003) Circulation , vol.107 , pp. 2775-2779
    • Mackness, B.1    Durrington, P.2    McElduff, P.3    Yarnell, J.4    Azam, N.5    Watt, M.6
  • 12
    • 0026493679 scopus 로고
    • High density lipoprotein is the major carrier of lipid preoxides in human blood plasma from fasting donors
    • Bowry VW, Stanley KK, Stocker R. High density lipoprotein is the major carrier of lipid preoxides in human blood plasma from fasting donors. Proc Natl Acad Sci USA. 1992;89:10316-10320.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 10316-10320
    • Bowry, V.W.1    Stanley, K.K.2    Stocker, R.3
  • 13
    • 0033817620 scopus 로고    scopus 로고
    • Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypersterolemic patients
    • Tomas M, Senti M, Garcia-Faria F, Vila J, Torrents A, Covas M, et al. Effect of simvastatin therapy on paraoxonase activity and related lipoproteins in familial hypersterolemic patients. Arterioscler Thromb Vasc Biol. 2000;20:2113-2119.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2113-2119
    • Tomas, M.1    Senti, M.2    Garcia-Faria, F.3    Vila, J.4    Torrents, A.5    Covas, M.6
  • 14
    • 4143149127 scopus 로고    scopus 로고
    • High-density lipoproteins in sepsis and septic shock: Metabolism, actions, and therapeutic applications
    • Wu A, Hinds CJ, Thiemermann C. High-density lipoproteins in sepsis and septic shock: metabolism, actions, and therapeutic applications. Shock. 2004;21:210-221.
    • (2004) Shock , vol.21 , pp. 210-221
    • Wu, A.1    Hinds, C.J.2    Thiemermann, C.3
  • 15
    • 22544469174 scopus 로고    scopus 로고
    • Paraoxonases and cardiovascular diseases: Pharmacological and nutritional influences
    • Aviram M, Rosenblatt M. Paraoxonases and cardiovascular diseases: pharmacological and nutritional influences. Curr Opin Lipidol. 2005;16:393-399.).
    • (2005) Curr Opin Lipidol , vol.16 , pp. 393-399
    • Aviram, M.1    Rosenblatt, M.2
  • 16
    • 0034880694 scopus 로고    scopus 로고
    • Paraoxonase promoter polymorphism T(-107)C and relative paraoxonase deficiency as determinants of risk of coronary artery disease
    • Leviev I, Righetti A, James RW. Paraoxonase promoter polymorphism T(-107)C and relative paraoxonase deficiency as determinants of risk of coronary artery disease. J Mol Med. 2001;79:457-463.
    • (2001) J Mol Med , vol.79 , pp. 457-463
    • Leviev, I.1    Righetti, A.2    James, R.W.3
  • 18
    • 0026075878 scopus 로고
    • Influence of serum paraoxonase polymorphism on serum lipids and lipoproteins
    • Saha N, Roy AC, Teo SH, Tay JSH, Ratnam SS. Influence of serum paraoxonase polymorphism on serum lipids and lipoproteins. Clin Genet. 1991;40:277-282.
    • (1991) Clin Genet , vol.40 , pp. 277-282
    • Saha, N.1    Roy, A.C.2    Teo, S.H.3    Tay, J.S.H.4    Ratnam, S.S.5
  • 19
    • 0028900876 scopus 로고
    • A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate
    • Hegele RA, Brunt JH, Connelly PW. A polymorphism of the paraoxonase gene associated with variation in plasma lipoproteins in a genetic isolate. Arterioscler Thromb Vasc Biol. 1995;15:89-95.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 89-95
    • Hegele, R.A.1    Brunt, J.H.2    Connelly, P.W.3
  • 20
    • 0031859456 scopus 로고    scopus 로고
    • Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus
    • Mackness B, Mackness MI, Arrol S, Turkie W, Julier K, Abuasha B, et al. Serum paraoxonase (PON1) 55 and 192 polymorphism and paraoxonase activity and concentration in non-insulin dependent diabetes mellitus. Atherosclerosis. 1998;139:341-349.
    • (1998) Atherosclerosis , vol.139 , pp. 341-349
    • Mackness, B.1    Mackness, M.I.2    Arrol, S.3    Turkie, W.4    Julier, K.5    Abuasha, B.6
  • 21
    • 4344583095 scopus 로고    scopus 로고
    • Effect of short term treatment with simvastatin and atorvastatin on lipid paraoxonase activity in patients with hyperlipoproteinaemia
    • Paragh G, Törocsik, Seres I, Harangi M, Illyés L, Balogh Z. Effect of short term treatment with simvastatin and atorvastatin on lipid paraoxonase activity in patients with hyperlipoproteinaemia. Curr Med Res Opin. 2004;20:1321-1327.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1321-1327
    • Paragh, G.1    Törocsik2    Seres, I.3    Harangi, M.4    Illyés, L.5    Balogh, Z.6
  • 22
    • 0347594016 scopus 로고    scopus 로고
    • Effect of 3-hydroxy-3- methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities
    • Beltowski J, Wojcicka G, Jemroz A. Effect of 3-hydroxy-3- methylglutarylcoenzyme A reductase inhibitors (statins) on tissue paraoxonase 1 and plasma platelet activating factor acetylhydrolase activities. J Cardiovasc Pharmacol. 2004;43:121-127.
    • (2004) J Cardiovasc Pharmacol , vol.43 , pp. 121-127
    • Beltowski, J.1    Wojcicka, G.2    Jemroz, A.3
  • 23
    • 0002923649 scopus 로고
    • Lipids, lipoproteins and apolipoproteins
    • Burtis CA, Ashwood ER, eds, 2nd ed. Philadelphia: W. B. Saunders;
    • Stein EA, Myers, GL. Lipids, lipoproteins and apolipoproteins. In: Burtis CA, Ashwood ER, eds. Tietz textbook of clinical chemistry. 2nd ed. Philadelphia: W. B. Saunders; 1994. p. 1002-1081.
    • (1994) Tietz textbook of clinical chemistry , pp. 1002-1081
    • Stein, E.A.1    Myers, G.L.2
  • 24
    • 0029897680 scopus 로고    scopus 로고
    • Homogeneous assay for direct determination of high density lipoprotein cholesterol evaluated
    • Nauck M, Marz W, Haas B, Wieland H. Homogeneous assay for direct determination of high density lipoprotein cholesterol evaluated. Clin Chem. 1996;42:424-429.
    • (1996) Clin Chem , vol.42 , pp. 424-429
    • Nauck, M.1    Marz, W.2    Haas, B.3    Wieland, H.4
  • 25
    • 0015348189 scopus 로고
    • Estimation of the concentration of low density lipoprotein cholesterol without the use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol without the use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 26
    • 0021828045 scopus 로고
    • Evaluation of a new HDL2/HDL3 quantitation method based on precipitation with polyethylene glycol
    • Kostner GM, Molinari E, Pichler P. Evaluation of a new HDL2/HDL3 quantitation method based on precipitation with polyethylene glycol. Clin Chim Acta. 1985;148:139-147.
    • (1985) Clin Chim Acta , vol.148 , pp. 139-147
    • Kostner, G.M.1    Molinari, E.2    Pichler, P.3
  • 27
    • 0020534463 scopus 로고
    • The human serum paraoxonase polymorphism: Identification of phenotypes by their response to salts
    • Eckerson HW, Romson J, Wyte C, La Du BN. The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am J Hum Genet. 1983; 35:214-227.
    • (1983) Am J Hum Genet , vol.35 , pp. 214-227
    • Eckerson, H.W.1    Romson, J.2    Wyte, C.3    La Du, B.N.4
  • 28
    • 0021070710 scopus 로고
    • The human serum paraoxonase/arylesterase polymorphism
    • Eckerson HW, Wyte C, La Du BN. The human serum paraoxonase/arylesterase polymorphism. Am J Hum Genet. 1983;35:1126-1138.
    • (1983) Am J Hum Genet , vol.35 , pp. 1126-1138
    • Eckerson, H.W.1    Wyte, C.2    La Du, B.N.3
  • 29
    • 0026096803 scopus 로고
    • Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities
    • Gan KN, Smolen HW, Eckerson BN, La Du BN. Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities. Drug Metab Dispos. 1991;19:100-106.
    • (1991) Drug Metab Dispos , vol.19 , pp. 100-106
    • Gan, K.N.1    Smolen, H.W.2    Eckerson, B.N.3    La Du, B.N.4
  • 30
    • 0004274433 scopus 로고    scopus 로고
    • StatSoft, Inc, Tulsa, OK: StatSoft. Available from
    • StatSoft, Inc. (2006). Electronic Statistics Textbook. Tulsa, OK: StatSoft. Available from: http://www.statsoft.com/textbook/stathome.html
    • (2006) Electronic Statistics Textbook
  • 31
    • 0029905656 scopus 로고    scopus 로고
    • La Du BN. Structural and functional diversity of paraoxonases. Nat Med. 1996;2:1186-1187.
    • La Du BN. Structural and functional diversity of paraoxonases. Nat Med. 1996;2:1186-1187.
  • 33
    • 0034663703 scopus 로고    scopus 로고
    • Effects of simvastatin (40 and 80 mg/day) in patients with mixed hyperlipidemia
    • Stein E, Plotkin D, Bays H, Davidson M, Dujovne C, Korenman S, et al. Effects of simvastatin (40 and 80 mg/day) in patients with mixed hyperlipidemia. Am J Cardiol. 2000; 86:406-411.
    • (2000) Am J Cardiol , vol.86 , pp. 406-411
    • Stein, E.1    Plotkin, D.2    Bays, H.3    Davidson, M.4    Dujovne, C.5    Korenman, S.6
  • 34
    • 12444339797 scopus 로고    scopus 로고
    • Atorvastatine ffect on high-density lipoprotein-associated paraoxonase activity and oxidative DNA damage
    • Harangi M, Seres I, Varga Z, Emri G, Szilvassy Z, Paragh G, et al. Atorvastatine ffect on high-density lipoprotein-associated paraoxonase activity and oxidative DNA damage. Eur J Clin Pharmacol. 2004;60:685-691.
    • (2004) Eur J Clin Pharmacol , vol.60 , pp. 685-691
    • Harangi, M.1    Seres, I.2    Varga, Z.3    Emri, G.4    Szilvassy, Z.5    Paragh, G.6
  • 35
    • 4344583095 scopus 로고    scopus 로고
    • Effect of short term treatment with simvastatin and atorvastatin on lipids and paraoxonase activity in patients with hyperlipoproteinaemia
    • Paragh G, Torocsik D, Seres I, Harangi M, Illyes L, Balogh Z, et al. Effect of short term treatment with simvastatin and atorvastatin on lipids and paraoxonase activity in patients with hyperlipoproteinaemia. Curr Med Res Opin. 2004;20: 1321-1327.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1321-1327
    • Paragh, G.1    Torocsik, D.2    Seres, I.3    Harangi, M.4    Illyes, L.5    Balogh, Z.6
  • 36
    • 4043072119 scopus 로고    scopus 로고
    • The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant-antioxidant system in patients with dyslipidemia
    • Rural BV, Orem C, Uydu HA, Alver A, Orem A. The effects of lipid-lowering therapy on paraoxonase activities and their relationships with the oxidant-antioxidant system in patients with dyslipidemia. Coron Artery Dis. 2004;15:277-283.
    • (2004) Coron Artery Dis , vol.15 , pp. 277-283
    • Rural, B.V.1    Orem, C.2    Uydu, H.A.3    Alver, A.4    Orem, A.5
  • 37
    • 27544515964 scopus 로고    scopus 로고
    • The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia
    • vanHimbergen TM, van Tits LJ, Voorbij HA, de Graaf J, Stalenhoef AF, Roest M. The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia. J Intern Med. 2005;258:442-449).
    • (2005) J Intern Med , vol.258 , pp. 442-449
    • vanHimbergen, T.M.1    van Tits, L.J.2    Voorbij, H.A.3    de Graaf, J.4    Stalenhoef, A.F.5    Roest, M.6
  • 39
    • 0347753257 scopus 로고    scopus 로고
    • Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: Effect of atorvastatin therapy
    • Rosenblat M, Hayek T, Hussein K, Aviram M. Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. Arterioscler Thromb Vasc Biol. 2004;24:175-180.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 175-180
    • Rosenblat, M.1    Hayek, T.2    Hussein, K.3    Aviram, M.4
  • 40
    • 0037245337 scopus 로고    scopus 로고
    • PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity
    • Jaouad L, Milochevitch C, Khalil A. PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity. Free Radic Res. 2003;37:77-83.
    • (2003) Free Radic Res , vol.37 , pp. 77-83
    • Jaouad, L.1    Milochevitch, C.2    Khalil, A.3
  • 41
    • 12944319318 scopus 로고    scopus 로고
    • Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene
    • Ota K, Suehiro T, Arii K, Ikeda Y, Kumon Y, Osaki F et al. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. Metabolism. 2005;54:142-150.
    • (2005) Metabolism , vol.54 , pp. 142-150
    • Ota, K.1    Suehiro, T.2    Arii, K.3    Ikeda, Y.4    Kumon, Y.5    Osaki, F.6
  • 42
    • 0029118601 scopus 로고
    • Gin-Arg 192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes
    • Ruiz J, Blanche H, James RW, Garin MC, Vaisse C, Charpentier G, et al. Gin-Arg 192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 1995; 346:869-872.
    • (1995) Lancet , vol.346 , pp. 869-872
    • Ruiz, J.1    Blanche, H.2    James, R.W.3    Garin, M.C.4    Vaisse, C.5    Charpentier, G.6
  • 43
    • 0028883658 scopus 로고
    • Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipid and lipoproteins
    • Abbott CA, Mackness MI, Kumar S, Boulton AJ, Durrington PN. Serum paraoxonase activity, concentration, and phenotype distribution in diabetes mellitus and its relationship to serum lipid and lipoproteins. Arterioscler Thromb Vasc Biol. 1995;11:1812-1818.
    • (1995) Arterioscler Thromb Vasc Biol , vol.11 , pp. 1812-1818
    • Abbott, C.A.1    Mackness, M.I.2    Kumar, S.3    Boulton, A.J.4    Durrington, P.N.5
  • 44
    • 21044436110 scopus 로고    scopus 로고
    • Antioxidant effect of atorvastatin is independent of PON1 gene T(-107)C, Q192R and L55M polymorphisms in hypercholesterolaemic patients
    • Sardo MA, Campo S, Bonaiuto M, Bonaiuto A, Saitta C, Trimarchi G, et al. Antioxidant effect of atorvastatin is independent of PON1 gene T(-107)C, Q192R and L55M polymorphisms in hypercholesterolaemic patients. Curr Med Res Opin. 2005;21:777-784.
    • (2005) Curr Med Res Opin , vol.21 , pp. 777-784
    • Sardo, M.A.1    Campo, S.2    Bonaiuto, M.3    Bonaiuto, A.4    Saitta, C.5    Trimarchi, G.6


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