Comment on: Gale EAM (2007) to boldly go-or to go too boldly? The accelerator hypothesis revisited. Diabetologia 50:1571-1575 - A reply to the editor [3]

Diabetologia

Volumn 50, Issue 12, 2007, Pages 2604-2606

  Wilkin, T J ^a  

^a DERRIFORD HOSPITAL   (United Kingdom)

Author keywords

Accelerator hypothesis; Aetiopathogenesis; Classification; Debate, type 1 diabetes

Indexed keywords

C PEPTIDE; METFORMIN;

APOPTOSIS; BODY MASS; DISEASE CLASSIFICATION; DISEASE COURSE; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; GENOTYPE; HLA SYSTEM; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LETTER; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RISK ASSESSMENT;

APOPTOSIS; DIABETES COMPLICATIONS; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS;

EID: 35848930120     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0829-3     Document Type: Letter

References (13)

1. Gale EAM (2007) To boldly go-or to go too boldly? The accelerator hypothesis revisited. Diabetologia 50:1571-1575
2. Wilkin TJ (2007) Changing perspectives in diabetes: their impact on its classification. Diabetologia 50:1587-1592
3. Wilkin TJ (2001) The accelerator hypothesis: weight gain as the missing link between type I and type ll diabetes. Diabetologia 44:914-922
4. Wilkin TJ (2007) The accelerator hypothesis cannot be tested using the type 2 diabetes gene, TCF7L2. Diabetologia 50:1780
5. Field SF, Howson JMM, Smyth DJ, Walker NM, Dunger DB, Todd JA (2007) Analysis of the type 2 diabetes gene, TCF7L2, in 13,795 type 1 diabetes cases and control subjects. Diabetologia 50:212-213
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9. Diabetes Prevention Trial-Type 1 Diabetes Study Group (2002) Effects of insulin on relatives of patients with type 1 diabetes. N Engl J Med 346:1658-1691
10. The European Nicotinamide Diabetes Intervention Trial (ENDIT) Group (2002) A randomised controlled trial of intervention before the onset of type 1 diabetes. Lancet 363:925-931
11. Dabelea D, D'Agostino RB, Mayer-Davis EJ et al (2006) Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes. Diabetes Care 29:290-294
12. Wilkin TJ (2006) Testing the accelerator hypothesis: body size, beta-cell function, and age at onset of type 1 (autoimmune) diabetes: response to Dabelea et al. Diabetes Care 29:1462-1463 (author reply 1463-1464)
13. Knowler WC, Barrett-Connor E, Fowler SE et al.; Diabetes Prevention Program Research Group (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403