SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model

Nuclear Medicine and Biology

Volumn 34, Issue 8, 2007, Pages 917-923

  Fang, Wei ^a   Wang, Feng ^b   Ji, Shundong ^c   Zhu, Xiaoguang ^d   Meier, Heidi T ^e   Hellman, Robert S ^d   Brindle, Kevin M ^f   Davletov, Bazbek ^g   Zhao, Ming ^d  

^a FUWAI HOSPITAL   (China)

^b THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

^d MEDICAL COLLEGE OF WISCONSIN   (United States)

^e CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^g UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

C2A domain; Myocardial infarction; SPECT imaging

Indexed keywords

RADIOPHARMACEUTICAL AGENT; SYNAPTOTAGMIN I TC 99M; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE MODEL; FEMALE; HEART; HEART INFARCTION; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY; RADIOACTIVITY; REPERFUSION INJURY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SWINE; TISSUE CULTURE;

ANIMALS; APOPTOSIS; COMPUTER SIMULATION; DISEASE MODELS, ANIMAL; HEART VENTRICLES; HUMANS; METABOLIC CLEARANCE RATE; MODELS, CARDIOVASCULAR; MYOCARDIAL REPERFUSION INJURY; ORGANOTECHNETIUM COMPOUNDS; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; SWINE; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 35848929261     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2007.06.014     Document Type: Article

References (31)

1. Jugdutt B.I., and Idikio H.A. Apoptosis and oncosis in acute coronary syndromes: assessment and implications. Mol Cell Biochem 270 (2005) 177-200
2. Zhao Z.Q., and Vinten-Johansen J. Myocardial apoptosis and ischemic preconditioning. Cardiovasc Res 55 (2002) 438-455
3. Freude B., Masters T.N., Kostin S., Robicsek F., and Schaper J. Cardiomyocyte apoptosis in acute and chronic conditions. Basic Res Cardiol 93 (1998) 85-89
4. Maisch B. How cardiac cells die - necrosis, oncosis and apoptosis. Herz 24 3 (1999) 181-188
5. Van Cruchten S., and Van Den Broeck W. Morphological and biochemical aspects of apoptosis, oncosis and necrosis. Anat Histol Embryol 31 (2002) 214-223
6. Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., and Henson P.M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. J Immunol 148 (1992) 2207-2216
7. Rucker-Martin C., Henaff M., Hatem S.N., Delpy E., and Mercadier J.J. Early redistribution of plasma membrane phosphatidylserine during apoptosis of adult rat ventricular myocytes in vitro. Basic Res Cardiol 94 (1999) 171-179
8. Bennett M.R., Gibson D.F., Schwart S., and Tait J.F. Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine. Circ Res 77 (1995) 1136-1142
9. Blankenberg F.G., Katsikis P.D., Tait J.F., et al. In vivo detection and imaging of phosphatidylserine expression during programmed cell death. Proc Natl Acad Sci U S A 95 (1998) 6349-6354
10. Blankenberg F.G. Recent advances in the imaging of programmed cell death. Curr Pharm Des 10 (2004) 1457-1467
11. Lahorte C.M., Vanderheyden J.L., Steinmetz N., Van de Wiele C., Dierckx R.A., and Slegers G. Apoptosis-detecting radioligands: current state of the art and future perspectives. Eur J Nucl Med Mol Imaging 31 (2004) 887-919
12. Zhao M., Beauregard D.A., Loizou L., Davletov B., and Brindle K.M. Non-invasive detection of apoptosis using magnetic resonance imaging and a targeted contrast agent. Nat Med 7 (2001) 1241-1244
13. Hofstra L., Liem I.H., Dumont E.A., et al. Visualisation of cell death in vivo in patients with acute myocardial infarction. Lancet 356 (2000) 209-212
14. Thimister P.W., Hofstra L., Liem I.H., et al. In vivo detection of cell death in the area at risk in acute myocardial infarction. J Nucl Med 44 (2003) 391-396
15. 99mTc-labeled C2A domain of synaptotagmin I as a target-specific molecular probe for the non-invasive imaging of acute myocardial infarction. J Nucl Med 47 (2006) 1367-1374
16. 99mTc-labeled C2A in the area at risk after myocardial ischemia and reperfusion. J Nucl Med 48 (2007) 1031-1036
17. Jung H.I., Kettunen M.I., Davletov B., and Brindle K.M. Detection of apoptosis using the C2A domain of synaptotagmin I. Bioconjug Chem 15 (2004) 983-987
18. Tesic M., Sheldon K.M., Ballinger J.R., et al. Labeling small quantities of monoclonal antibody and their F(ab′)2 fragments with technetium-99m. Nucl Med Biol 22 (1995) 451-457
19. Kawamoto K., Herz F., Wolley R.C., Hirano A., and Koss L.G. Flow cytometric analysis of the DNA content in cultured human brain tumor cells. Virchows Arch B Cell Pathol Incl Mol Pathol 35 (1980) 11-17
20. Fritzberg A.R., and Beaumier P.L. Targeted proteins for diagnostic imaging: does chemistry make a difference?. J Nucl Med 33 (1992) 394-397
21. Verbeke K., Hjelstuen O., Debrock E., Cleynhens B., De Roo M., and Verbruggen A. Comparative evaluation of 99Tcm-Hynic-HSA and 99Tcm-MAG3-HSA as possible blood pool agents. Nucl Med Commun 16 (1995) 942-957
22. Steffens M.G., Oosterwijk E., Kranenborg M.H., et al. In vivo and in vitro characterizations of three 99mTc-labeled monoclonal antibody G250 preparations. J Nucl Med 40 (1999) 829-836
23. Qu T., Wang Y., Zhu Z., Rusckowski M., and Hnatowich D.J. Different chelators and different peptides together influence the in vitro and mouse in vivo properties of 99Tcm. Nucl Med Commun 22 (2001) 203-215
24. 99mTc-labeled annexin V. J Nucl Med 45 (2004) 1536-1541
25. Luckcuck T., Trotter P.J., and Walker J.H. Localization of annexin V in the adult and neonatal heart. Biochem Biophys Res Comm 238 (1997) 622-628
26. Pula G., Bianchi R., Ceccarelli P., Giambanco I., and Donato R. Characterization of mammalian heart annexins with special reference to CaBP33 (annexin V). FEBS Lett 277 (1990) 53-58
27. Spreca A., Rambotti M.G., Giambanco I., Pula G., Bianchi R., Ceccarelli P., et al. Immunocytochemical localization of annexin V (CaBP33), a Ca(2+)-dependent phospholipid- and membrane-binding protein, in the rat nervous system and skeletal muscles and in the porcine heart. J Cell Physiol 152 (1992) 587-598
28. Doubell A.F., Lazure C., Charbonneau C., and Thibault G. Identification and immunolocalisation of annexins V and VI, the major cardiac annexins, in rat heart. Cardiovasc Res 27 (1993) 1359-1367
29. Sarda-Mantel L., Michel J.B., Rouzet F., Martet G., Louedec L., Vanderheyden J.L., et al. Eur J Nucl Med Mol Imaging 33 (2006) 239-245
30. Zhang X., Rizo J., and Sudhof T.C. Mechanism of phospholipid binding by the C2A-domain of synaptotagmin I. Biochemistry 37 (1998) 12395-12403
31. Sutton R.B., Davletov B.A., Berghuis A.M., Sudhof T.C., and Sprang S.R. Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold. Cell 80 (1995) 929-938