Central representation of the RIII flexion reflex associated with overt motor reaction: An fMRI study

Neurophysiologie Clinique

Volumn 37, Issue 4, 2007, Pages 249-259

  Peyron, R ^a,c   Kupers, R ^b   Jehl, J L ^a   Garcia Larrea, L ^c   Convers, P ^a,c   Barral, F G ^a   Laurent, B ^a,c  

^a UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

^b Rigshospitalet   (Denmark)

^c UNIVERSITÉ JEAN MONNET   (France)

Author keywords

Human; Insula; Motor component; Nociceptive flexion reflex; Pain imaging

Indexed keywords

ADULT; ARTICLE; BRAIN CORTEX; BRAIN FUNCTION; CONTROLLED STUDY; ELECTRIC SHOCK; FLEXOR REFLEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; MALE; MOTOR ACTIVITY; MOTOR PERFORMANCE; NEUROIMAGING; NOCICEPTION; NOCICEPTIVE STIMULATION; PAIN ASSESSMENT; STIMULATION;

ADULT; AREA UNDER CURVE; BRAIN STEM; ELECTRIC STIMULATION; ELECTROSHOCK; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; PAIN; PAIN THRESHOLD; PSYCHOPHYSICS; REFLEX;

EID: 35748983197     PISSN: 09877053     EISSN: 17697131     Source Type: Journal    
DOI: 10.1016/j.neucli.2007.07.002     Document Type: Article

References (51)

1. Melzack R., and Casey K.L. sensory, motivational and central control determinants of pain: a new conceptual model. In: Kenshalo D.R. (Ed). The shin senses (1968), Springfield, IL, Thomas 423-443
2. Hsieh J.C., Hagermark O., Stahle-Backdahl M., et al. Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 72 (1994) 3004-3008
3. Bucher S.F., Seelos K.C., Oertel W.H., Reiser M., and Trenkwalder C. Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol 41 (1997) 639-645
4. Timmann D., Kolb F.P., Baier C., et al. Cerebellar activation during classical conditioning of the human flexion reflex: a PET study. Neuroreport 7 (1996) 2056-2060
5. Buchel C., Bornhovd K., Quante M., Glauche V., Bromm B., and Weiller C. Dissociable neural responses related to pain intensity, stimulus intensity and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study. J Neurosci 22 (2002) 970-976
6. Willer J.C. Comparative study of perceived pain and nociceptive flexion reflex in man. Pain 3 (1977) 69-80
7. Garcia-Larrea L., and Mauguiere F. Electrophysiological assessment of nociception in normals and patients: the use of nociceptive reflexes. Electroencephalogr Clin Neurophysiol Suppl 41 (1990) 102-118
8. Skljarevski V., and Ramadan N.M. The nociceptive flexion reflex in humans - review article. Pain 96 (2002) 3-8
9. Danziger N., Fournier E., Bouhassira D., et al. Different strategies of modulation can be operative during hypnotic analgesia: a neurophysiological study. Pain 75 (1998) 85-92
10. Sandrini G., Milanov I., Rossi B., et al. Effects of sleep on spinal nociceptive reflexes in humans. Sleep 24 (2001) 13-17
11. Villanueva L., Bouhassira D., and Le Bars D. The medullary subnucleus reticularis dorsalis (SRD) as a key link in both the transmission and modulation of pain signals. Pain 67 (1996) 231-240
12. Willer J.C., Boureau F., and Albe-Fessard D. Supraspinal influences on nociceptive flexion reflex and pain sensation in man. Brain Res 179 (1979) 61-68
13. Apkarian A.V., Bushnell M.C., Treede R.D., and Zubieta J.K. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 9 (2005) 463-484
14. Derbyshire S.W. Meta-analysis of thirty-four independent samples studied using PET reveals a significantly attenuated central response to noxious stimulation in clinical pain patients. Curr Rev Pain 3 (1999) 265-280
15. Jones A.K., Kulkarni B., and Derbyshire S.W. Pain mechanisms and their disorders. Br Med Bull 65 (2003) 83-93
16. Peyron R., Laurent B., and Garcia-Larrea L. Functional imaging of brain responses to pain. A review and meta- analysis (2000). Neurophysiol Clin 30 (2000) 263-288
17. Xu X., Fukuyama H., Yazawa S., et al. Functional localization of pain perception in the human brain studied by PET. Neuroreport 8 (1997) 555-559
18. Derbyshire S.W., Jones A.K., Gyulai F., Clark S., Townsend D., and Firestone L.L. Pain processing during three levels of noxious stimulation produces differential patterns of central activity. Pain 73 (1997) 431-445
19. Svensson P., Minoshima S., Beydoun A., Morrow T.J., and Casey K.L. Cerebral processing of acute skin and muscle pain in humans. J Neurophysiol 78 (1997) 450-460
20. Bornhovd K., Quante M., Glauche V., Bromm B., Weiller C., and Buchel C. Painful stimuli evoke different stimulus-response functions in the amygdala, prefrontal, insula and somatosensory cortex: a single-trial fMRI study. Brain 125 (2002) 1326-1336
21. Youell P.D., Wise R.G., Bentley D.E., et al. Lateralisation of nociceptive processing in the human brain: a functional magnetic resonance imaging study. Neuroimage 23 (2004) 1068-1077
22. Bingel U., Lorenz J., Schoell E., Weiller C., and Buchel C. Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network. Pain 120 (2006) 8-15
23. Willer J.C., Boureau F., and Berny J. Nociceptive flexion reflexes elicited by noxious laser radiant heat in man. Pain 7 (1979) 15-20
24. Coull J.T., Frith C.D., Buchel C., and Nobre A.C. Orienting attention in time: behavioural and neuroanatomical distinction between exogenous and endogenous shifts. Neuropsychologia 38 (2000) 808-819
25. Gitelman D.R., Nobre A.C., Parrish T.B., et al. A large-scale distributed network for covert spatial attention: further anatomical delineation based on stringent behavioural and cognitive controls. Brain 122 (1999) 1093-1106
26. Posner M.I., and Dehaene S. Attentional networks. Trends Neurosci 17 (1994) 75-79
27. Peyron R., Garcia-Larrea L., Gregoire M.C., et al. Haemodynamic brain responses to acute pain in humans: sensory and attentional networks. Brain 122 (1999) 1765-1780
28. Lorenz J., Minoshima S., and Casey K.L. Keeping pain out of mind: the role of the dorsolateral prefrontal cortex in pain modulation. Brain 126 (2003) 1079-1091
29. Craig A.D., Chen K., Bandy D., and Reiman E.M. Thermosensory activation of insular cortex. Nat Neurosci 3 (2000) 184-190
30. Coghill R.C., Sang C.N., Maisog J.M., and Iadarola M.J. Pain intensity processing within the human brain: a bilateral, distributed mechanism. J Neurophysiol 82 (1999) 1934-1943
31. Alkire M.T., White N.S., Hsieh R., and Haier R.J. Dissociable brain activation responses to 5-Hz electrical pain stimulation: a high-field functional magnetic resonance imaging study. Anesthesiology 100 (2004) 939-946
32. Frot M., Magnin M., Mauguiere F., and Garcia-Larrea L. Human SII and posterior insula differently encode thermal laser stimuli. Cereb Cortex 17 (2006) 610-620
33. Timmermann L., Ploner M., Haucke K., Schmitz F., Baltissen R., and Schnitzler A. Differential coding of pain intensity in the human primary and secondary somatosensory cortex. J Neurophysiol 86 (2001) 1499-1503
34. Derbyshire S.W., and Jones A.K. Cerebral responses to a continual tonic pain stimulus measured using positron emission tomography. Pain 76 (1998) 127-135
35. Iadarola M.J., Berman K.F., Zeffiro T.A., et al. Neural activation during acute capsaicin-evoked pain and allodynia assessed with PET. Brain 121 (1998) 931-947
36. Paulson P.E., Minoshima S., Morrow T.J., and Casey K.L. Gender differences in pain perception and patterns of cerebral activation during noxious heat stimulation in humans. Pain 76 (1998) 223-229
37. Grafton S.T., Fagg A.H., and Arbib M.A. Dorsal premotor cortex and conditional movement selection: A PET functional mapping study. J Neurophysiol 79 (1998) 1092-1097
38. Jueptner M., Stephan K.M., Frith C.D., Brooks D.J., Frackowiak R.S., and Passingham R.E. Anatomy of motor learning. I. Frontal cortex and attention to action. J Neurophysiol 77 (1997) 1313-1324
39. Mima T., Sadato N., Yazawa S., et al. Brain structures related to active and passive finger movements in man. Brain 122 Pt 10 (1999) 1989-1997
40. Radovanovic S., Korotkov A., Ljubisavljevic M., et al. Comparison of brain activity during different types of proprioceptive inputs: a positron emission tomography study. Exp Brain Res 143 (2002) 276-285
41. Reddy H., Floyer A., Donaghy M., and Matthews P.M. Altered cortical activation with finger movement after peripheral denervation: comparison of active and passive tasks. Exp Brain Res 138 (2001) 484-491
42. Casey K.L. Forebrain mechanisms of nociception and pain: analysis through imaging. Proc Natl Acad Sci U S A 96 (1999) 7668-7674
43. Casey K.L., Minoshima S., Morrow T.J., and Koeppe R.A. Comparison of human cerebral activation pattern during cutaneous warmth, heat pain, and deep cold pain. J Neurophysiol 76 (1996) 571-581
44. Hsieh J.C., Stahle-Backdahl M., Hagermark O., Stone-Elander S., Rosenquist G., and Ingvar M. Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain 64 (1996) 303-314
45. Tolle T.R., Kaufmann T., Siessmeier T., et al. Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis. Ann Neurol 45 (1999) 40-47
46. Fields H.L., Malick A., and Burstein R. Dorsal horn projection targets of ON and OFF cells in the rostral ventromedial medulla. J Neurophysiol 74 (1995) 1742-1759
47. Hillman P., and Wall P.D. Inhibitory and excitatory factors influencing the receptive fields of lamina 5 spinal cord cells. Exp Brain Res 9 (1969) 284-306
48. Le Bars D., Dickenson A.H., and Besson J.M. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 6 (1979) 283-304
49. Sandrini G., Milanov I., Malaguti S., Nigrelli M.P., Moglia A., and Nappi G. Effects of hypnosis on diffuse noxious inhibitory controls. Physiol Behav 69 (2000) 295-300
50. Willer J.C., Roby A., and Le Bars D. Psychophysical and electrophysiological approaches to the pain- relieving effects of heterotopic nociceptive stimuli. Brain 107 (1984) 1095-1112
51. Gozariu M., Bouhassira D., Willer J.C., and Le Bars D. The influence of temporal summation on a C-fibre reflex in the rat: effects of lesions in the rostral ventromedial medulla (RVM). Brain Res 792 (1998) 168-172