Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: A positron emission tomography study

Pain

Volumn 64, Issue 2, 1996, Pages 303-314

  Hsieh, Jen Chuen ^a,b   Ståhle Bäckdahl, Mona ^a   Hägermark, Östen ^a   Stone Elander, Sharon ^a   Rosenquist, Göran ^a   Ingvar, Martin ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

human brain; hypothalamus; pain; periaqueductal gray; positron emission tomography; regional cerebral blood flow; trauma

Indexed keywords

ALCOHOL;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; MALE; NOCICEPTION; NORMAL HUMAN; PAIN; PERIAQUEDUCTAL GRAY MATTER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PSYCHOPHYSICS; SKIN INJURY;

EID: 17144435871     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00129-8     Document Type: Article

References (93)

1. Aggleton, J.P., The contribution of the amygdala to normal and abnormal emotional states, Trends Neurosci., 16 (1993) 328-333.
2. Andersen, R.A., Inferior parietal lobule function in spatial perception and visuomotor integration. In: V.B. Mountcastle, F. Plum and S.R. Geiger (Eds.), Handbook of Physiology, Sect. 1, The Nervous System, Vol. V, Higher Functions of the Brain, Part 2, American Physiological Society, Bethesda, MD, 1987, pp. 483-518.
3. Apkarian, A.V., Stea, R.A., Manglos, S.H., Szeverenyi, N.M., King, R.B. and Thomas, F.D., Persistent pain inhibits contralateral somatosensory cortical activity in humans, Neurosci. Lett., 140 (1992) 141-147.
4. Arntz, A., Dreessen, L. and DeLong, P., The influence of anxiety on pain: attentional and attributional mediators, Pain, 56 (1994) 307-314.
5. Bandler, R. and Shipley, M.T., Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?, Trends Neurosci., 17 (1994) 379-389.
6. Bentivoglio, M., Kultas-llinsky, K. and Ilinsky, I., Limbic thalamus: structure, intrinsic organization, and connections. In: B.A. Vogt and M. Gabriel (Eds.), Neurobiology of Cingulate Cortex and Limbic Thalamus: A comprehensive Handbook, Birkhäuser, Boston, MA, 1993, pp. 71-122.
7. Bergström, M., Boethius, J., Eriksson, L., Greitz, T., Ribbe, T. and Widen, L., Head fixation device for reproducible position alignment in transmission CT and positron emission tomography, J. Comput. Assist. Tomogr., 5 (1981) 136-141.
8. Bohm, C., Greitz, T. and Eriksson, L., A computerized adjustable brain atlas, Eur. J. Nucl. Med., 15 (1989) 687-689.
9. Bouckoms, A.J., Limbic surgery for pain, In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, 3rd edn., Churchill Livingstone, Edinburgh, 1994, pp. 1171-1187.
10. Brodmann, K., Vergleichende Lokalisationslehre der Grosshimrinde, Barth, Leipzig, 1909.
11. Burton, H., Videen, T.O. and Raichle, M.E., Tactile-vibration-activated foci in insular and parietal-opercular cortex studied with positron emission tomography: mapping the second somatosensory area in humans, Somatosens. Mot. Res., 10 (1993) 297-308.
12. Bushnell, M.C. and Duncan, G.H., Sensory and affective aspects of pain perception: is medial thalamic neurons restricted to emotional issues?, Exp. Brain Res., 78 (1989) 415-418.
13. Canavero, S., Pagni, C.A., Castellano, G., Bonicalzi, V., Bello, M., Duca, S. and Podio, V., The role of contex in central pain syndromes: preliminary results of a long-term technetium-99 nexamethylpropyleneamineoxime single photon emission computed tomography study, Neurosurgery, 32 (1993) 185-189; Discussion 190-191.
14. Casey, K.L., Minoshima, S., Berger, K.L., Koeppe, R.A., Morrow, T.J. and Frey, K.A., Positron emission tomography analysis of cerebral structures activated specifically by repetitive noxious heat stimuli, J. Neurophysiol., 2 (1994) 802-807.
15. Casey, K.L., Minoshima, S., Koeppe, R.A., Morrow, T.J. and Frey, K.A., Differences in cortical and subcortical responses to noxious heat and cold stimuli in humans., Soc. Neurosci. Abst., 19 (1993) 1074.
16. Cavada, C. and Goldman-Rakic, P.S., Posterior parietal cortex in rhesus monkey. 1. Parcellation of areas based on distinctive limbic and sensory corticocortical connections, J. Comp. Neurol., 287 (1989) 393-421.
17. Cesaro, P., Mann, M.W., Moretti, J.L., Defer, G., Roualdés, B., Nguyen, J.P. and Degos, J.D., Central pain and thalamic hyperactivity: a single photon emission computerized tomographic study, Pain, 47 (1991) 329-336.
18. Chudler, E.H. and Dong, W.K., The role of the basal ganglia in nociception and pain, Pain, 60 (1995) 3-38.
19. Coghill, R.C., Morin, C., Evans, A.C., Meyer, E., Gjedde, A., Duncan, G.H. and Bushnell, M.C., Cerebral Blood flow (CBF) during tonic pain in man, Soc. Neurosci. Abstr., 19 (1993) 1573.
20. Coghill, R.C., Talbot, J.D., Evans, A.C., Meyer, E., Gjedde, A., Bushnell, M.C. and Duncan, G.H., Distributed processing of pain and vibration by the human brain, J. Neurosci., 14 (1994) 4095-4108.
21. Cohen, R.A., The Neuropsychology of Attention, Plenum Press, New York, 1993.
22. Cousins, M., Acute and postoperative pain. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, 3rd edn., Churchill Livingstone, Edinburgh, 1994, pp. 357-385.
23. Craig, A.D., Bushnell, M.C., Zhang, E.-T. and Blomqvist, A., A thalamic nucleus specific for pain and temperature sensation, Nature, 372 (1994) 770-773.
24. Davis, K.D., Hutchison, W.D., Lozano, A.M. and Dostrovsky, J.O., Altered pain and temperature perception following cingulotomy and capsulotomy in a patient with schizoaffective disorder, Pain, 59 (1994) 189-199.
25. Derbyshire, S.W.G., Jones, A.K.P., Brown, W.D., Devani, P., Friston, K.J., Qi, L.Y., Pearce, S., Frackowiak, R.S.J. and Jones, T., Cortical and subcortical responses to pain in male and female volunteers, J. Cereb. Blood Flow Metab., 13 (Suppl. 1) (1993) 5546.
26. Derbyshire, S.W.G., Jones, A.K.P., Devani, P., Friston, K.J., Feinmann, C., Harris, M., Pearce, S., Watson, J.D.G. and Frackowiak, R.S.J., Cerebral responses to pain in patients with atypical facial pain measured by positron emission tomography, J. Neurol. Neurosurg. Psychiat., 57 (1994) 1166-1172.
27. Devinsky, Q., Morrell, M.J. and Vogt, B.A., Contributions of anterior cingulate cortex to behaviour, Brain, 118 (1995) 279-306.
28. DiPiero, V., Ferracuti, S., Sabatini, U., Pantano, P., Cruccu, G. and Lenzi, G.L., A cerebral blood flow study on tonic pain activation in man, Pain, 56 (1994) 167-173.
29. DiPiero, V., Jones, A.K.P., Iannotti, F., Powell, M., Perani, D., Lenzi, G.L. and Frackowiak, R.S.J., Chronic pain: a PET study of the central effects of percutaneous high cervical cordotomy, Pain, 46 (1991) 9-12.
30. Dong, W.K., Chudler, E.H., Sugiyama, K., Roberts, V.J. and Hayashi, T., Somatosensory, multisensory and task-related neurons in cortical area Th (PF) of unanesthetized monkeys, J. Neurophysiol., 72 (1994) 542-564.
31. Dong, W.K., Salonen, L.D., Kawakami, Y., Shiwaku, T., Kaukoranta, E.M. and Martin, R.F., Nociceptive responses of trigeminal neurons in SII-7b cortex of awake monkeys, Brain Res., 484 (1989) 314-324.
32. Drevets, W.C., Burton, H., Videen, T.O., Snyder, A.Z., Simpson, J.RJ. and Raichle, M.E., Blood flow changes in human somatosensory cortex during anticipated stimulation, Nature, 373 (1995) 249-252.
33. Dum, R.P. and Strick, P.L., Cingulate motor areas. In: B.A. Vogt and M. Gabriel (Eds.), Neurobiology of Cingulate Cortex and Limbic Thalamus, Birkhäuser, Boston, 1993, pp. 415-444.
34. Duncan, G.H., Bushnell, M.C., Talbot, J.D., Evans, A.C., Meyer, E. and Marrett, S., Technical comment: localization of responses to pain in human cerebral cortex, Science, 255 (1991) 215-216.
35. Duncan, G.H., Bushness, M.C. and Lavigne, G.J., Comparison of verbal and visual analogue scales for measuring the intensity and unpleasantness of experimental pain, Pain, 37 (1989) 295-303.
36. Duncan, G.H., Morin, C., Coghill, R.C., Evans, A., Worsley, K.J. and Bushnell, M.C., Using psychophysical ratings to map the human brain: regression of regional cerebral blood flow (rCBF) to tonic pain perception, Soc. Neurosci. Abstr., 20 (1994) 1672.
37. Foit, A., Larsen, B., Hattori, S., Skinhøj, E. and Lassen, N.A., Cortical activation during somatosensory stimulation and voluntary movement in man: a regional cerebral blood flow study, Electroenceph. Clin. Neurophysiol., 50 (1980) 426-436.
38. Folkman, S. and Lazarus, R.S., Coping and emotion. In: A. Monat and R.S. Lazarus (Eds.), Stress and Coping, Columbia University Press, New York, 1991, pp. 207-227.
39. Frackowiak, R.S.J., Functional mapping of verbal memory and language, Trends Neurosci., 17 (1994) 109-115.
40. Friston, K.J., Frith, C.D., Liddle, P.F. and Frackowiak, R.S.J., Comparing functional (PET) images: the assessment of significant change, J. Cereb. Blood Flow Metab., 11 (1991) 690-699.
41. Gelnar, P.A., Szeverenyi, N.M. and Apkarian, A.V., Sll has the most robust response of the multiple cortical areas activated during painful thermal stimuli in humans, Soc. Neurosci. Abstr., 20 (1994) 1572.
42. George, M.S., Ketter, T.A., Parekh, P.I., Rosinsky, N., Ring, H., Casey, B.J., Trimble, M.R., Horwitz, B., Herscovitch, P. and Post, R.M., Regional brain activity with selecting a response despite interference: an H215O PET study of the Stroop and an emotional Stroop, Hum. Brain Map., 1 (1994) 194-209.
43. Ghatan, P.H., Hsieh, J.C., Wirsén-Meurling, A., Wredling, R., Eriksson, L., Stone-Elander, S., Levander, S. and Ingvar, M., Brain activation induced by the perceptual maze test: a PET study of cognitive performance. Neuroimage, 2 (1995) 112-124.
44. Giesler, G.J.J., Katter, J.T. and Dado, R.I., Direct spinal pathways to the limbic system for nociceptive information, Trends Neurosci., 17 (1994) 244-250.
45. Graeff, F.G., Brain defense systems and anxiety. In: M. Roth, G. D. Burrows and R. Noyes (Eds.), Handbook of Anxiety, Vol. 3, Elsevier, Amsterdam, 1990, pp. 307-354.
46. Greitz, T., Bohm, C., Holte, S. and Eriksson, L., A computerized brain atlas: construction, anatomical content and some applications, J. Comput. Assist. Tomogr., 15 (1991) 26-38.
47. Haxby, J.V., Horwitz, B., Ungerleider, L.G., Maisog, J.M., Pietrini, P. and Grady, C.L., The functional organization of human extrastriate cortex: a PET-rCBF study of selective attention to faces and locations, J. Neurosci., 14 (1994) 6336-6353.
48. Heilman, K.M., Watson, R.T., Valenstein, E. and Goldberg, M.E., Attention: behavior and neural mechanism. In: V.B. Mountcastle, F. Plum and S.R. Geiger (Eds.), Handbook of Physiology. Sect. 1, The Nervous System, Vol. V, Higher Functions of the Brain, Part 1, American Physiological Society, Bethesda, MD, 1987, pp. 461-481.
49. Hodge, C.J.J. and Apkarian, A.V., The spinothalamic tract, Crit. Rev. Neurobiol., 5 (1990) 363-397.
50. Holte, S., Eriksson, L. and Dahlbom, M., A preliminary evaluation of the Scanditronix PC-2048-ISB brain scanner, Eur. J. Nucl. Med., 15 (1989) 719-721.
51. Hsieh, J.-C, Hägermark, Ö., Stahle-Bäckdahl, M., Ericson, K., Eriksson, L., Stone-Stander, S. and Ingvar, M., The urge to scratch represented in human cerebral cortex, J. Neurophysiol., 72 (1994) 3004-3008.
52. Hsieh, J.-C., Belfrage, M., Stone-Elander, S., Hansson, P. and Ingvar, M., Central representation of chronic ongoing neuropathic pain studied by positron emission tomography, Pain, in press (1995).
53. 2O PET: timing of injection and tracer delivery, J. Cereb Blood Flow Metab., 14 (1994) 423-430.
54. Iadarola, M.J., Berman, K.F., Byas-Smith, M., Gracely, R.H., Max, M., Zeffiro, T. and Bennett, G.J., Positron emission tomography (PET) studies of pain and allodynia in normals and patients with chronic neuropathic pain, Soc. Neurosci. Abstr., 19 (1993) 1074.
55. Iadarola, M.J., Max, M.B., Berman, K.F., Byas-Smith, M.G., Coghill, R.C. and Gracely, R.H., Unilateral decrease in thalamic activity observed with positron emission tomography in patients with chronic neuropathic pain, Pain, in press (1995).
56. 15O]butanol and positron emission tomography, J. Cereb. Blood Flow Metab., 14 (1994) 628-638.
57. Jones, A.K.P., Brown, W.D., Friston, K.J., Qi, L.Y. and Frackowiak, R.S.J., Cortical and subcortical localization of response to pain in man using positron emission tomography, Proc. R. Soc. Lond. B, 244 (1991) 39-44.
58. Kawashima, R., Roland, P.E. and O'Sullivan, B.T., Functional anatomy of reaching and visuomotor learning: a positron emission tomography, Cereb. Cortex, 2 (1995) 111-122.
59. Kawashima, R., Roland, P.E. and O'Sullivan, B.T., Fields in human motor area involved in preparation for reaching and visuomotor learning: a positron emission tomography study, J. Neurosci., 14 (1994) 3462-3474.
60. Kew, J.I.M., Ridding, M.C., Rothwell, J.C., Passingham, R.E., Leigh, P.N., Sooriakumaran, S., Frackowiak, R.S.I, and Brooks, D.I., Reorganization of cortical blood flow and transcranial magnetic stimulation maps in human subjects after upper limb amputation, J. Neurophysiol., 72 (1994) 2517-2524.
61. Kupfermann, I., Hypothalamus and limbic system: peptidergic neurons, homeostasis, and emotional behavior. In: E.R. Kandel, J.H. Schwartz and T.M. Jessell (Eds.), Principles of Neural Science, 3rd edn., Elsevier, London, 1993, pp. 735-749.
62. Lazarus, R.S., Emotion and Adaptation, Oxford, New York, 1991.
63. LeDoux, J.E., Cognition and emotion. In: M.S. Gazzaniga (Eds.), Handbook of Cognitive Neuroscience, Plenum Press, London, 1984, pp. 357-368.
64. Leventhal, H., Brown, D., Shacham, S. and Engquist, G., Effects of preparatory information about sensations, threat of pain, and attention on cold pressor distress, J. Pers. Soc. Psychol., 37 (1979) 688-714.
65. Leventhal, H. and Everhart, D., Emotion, pain, and physical illness. In: C.E. Izard (Ed.), Emotions in Personality and Psychopathology, Plenum Press, London, 1979, pp. 261-299.
66. Libet, B., Electrical stimulation of cortex in human subjects and conscious sensory aspects. In: A. Iggo (Eds.), Handbook of Sensory Physiology, Vol. 2, Springer, Berlin, 1973, pp. 744-790.
67. Lim, S.H., Dinner, D.S., Pillay, P.K., Ltiders, H., Morris, H.H., Klem, G., Wyllie, E. and Awad, I.A., Functional anatomy of the human supplementary sensorimotor area: results of extraoperative electrical stimulation, Electroenceph. Clin. Neurophysiol., 91 (1994) 179-193.
68. Liotti, M., Gay, C.T. and Fox, P.T., Functional imaging and language: evidence from positron emission tomography, J. Clin. Neurophysiol., 11 (1994) 175-190.
69. Mathews, A., Why worry? The cognitive function of anxiety, Behav. Res. Ther., 28 (1990) 455-468.
70. Melzack, R. and Casey, K.L., Sensory, motivational, and central control determinants of pain. In: D.R. Kenshalo (Eds.), The Skin Senses, CC Thomas, Springfield, IL, 1968, pp. 423-439.
71. Mesulam, M.M. and Mufson, E.F., The insula of Reil in man and monkey. Architectonics, connectivity and function. In: A. Peters and E.G. Jones (Eds.), Cerebral Cortex, Vol. 4, Plenum Press, New York, 1985, pp. 179-226.
72. Pardo, J.V., Fox, P.T. and Raichle, M.E., Localization of a human system for sustained attention by positron emission tomography, Nature, 349 (1991) 61-64.
73. Pardo, J.V., Pardo, P.I., Janer, K.W. and Raichle, M.E., The anterior cingulate cortex mediates processing selection in the Stroop attentional conflict paradigm, Proc. Natl. Acad. Sci. USA, 87 (1990) 256-259.
74. Paus, T., Petrides, M., Evans, A.C. and Meyer, E., Role of the human anterior cingulate cortex in the control of oculomotor, manual and speech responses: a positron emission tomography study, J. Neurophysiol., 70 (1993) 453-469.
75. Penfield, W. and Rasmussen, T., The Cerebral Cortex of Man, Macmillan, New York, 1955.
76. Porrino, L.J., Cortical mechanisms of reinforcement. In: B.A. Vogt and M. Gabriel (Eds.), Neurobiology of Cingulate Cortex and Limbic Thalamus: a Comprehensive Handbook, Birkhäuser, Boston, MA, 1993, pp. 445-461.
77. Posner, M.I., Attention: the mechanisms of consciousness, Proc. Natl. Acad. Sci. USA, 91 (1994) 7398-7403.
78. Posner, M.I. and Raichle, M.E., Images of Mind, Scientific American Library, New York, 1994.
79. Price, D.D., Psychological and Neural Mechanisms of Pain, Raven Press, New York, 1988.
80. Rosen, S.D., Paulesu, E., Frith, C.D., Frackowiak, R.S.J., Davies, G.I., Jones, T. and Camici, P.G., Central nervous pathways mediating angina pectoris, Lancet, 344 (1994) 147-150.
81. Schmahmann, J.D. and Pandya, D.N., Anatomical investigation of projections from thalamus to posterior parietal cortex in the rhesus monkey: a WGA-HRP and fluorescent tracer study, J. Comp. Neurol., 295 (1990) 299-326.
82. Seitz, R.I. and Roland, P.E., Vibratory stimulation increases and decrease the regional cerebral blood flow and oxidative metabolism: a positron emission tomography (PET) study, Acta. Neurol. Scand., 86 (1992) 60-67.
83. Sergent, J., Brain-imaging studies of cognitive functions, Trend Neurosci., 17 (1994) 221-227.
84. Spielberger, C.D., Gorsuch, R.L. and Lushene, R., Manual for the State-Trait Anxiety Inventory, Consulting Psychologists' Press, Palo Alto, CA, 1970.
85. Stein, J.F., Representation of egocentric space in the posterior parietal cortex, Quart. J. Exp. Physiol., 74 (1989) 583-606.
86. Swanson, L.W., The hypothalamus. In: A. Björklund, T. Hökfek and L. W. Swanson (Eds.), Handbook of Chemical Neuroanatomy, Elsevier, New York, 1987, pp. 1-124.
87. Talairach, J. and Tournoux, P., Co-Planar Stereotaxic Atlas of the Human Brain, George Thieme, Stuttgart, 1988.
88. Talbot, J.D., Marrett, S., Evans, A.C., Meyer, E., Bushnell, M.C. and Duncan, G.H., Multiple representations of pain in human cerebral cortex, Science, 251 (1991) 1355-1358.
89. Thierry, A.-M., Godbout, R., Mantz, J. and Glowinski, J., Influence of the ascending monoammergic systems on the activity of the rat prefrontal cortex. In: H.B.M. Ulyings, C.G.V. Eden, J.P.C.D. Bruin, M.A. Corner and M.G.P. Feenstra (Eds.), The Prefrontal Cortex: Its Structure, Function and Pathology, Vol. 85, Prog. Brain Res., Vol. 85, Elsevier, Amsterdam, 1990, pp. 357-365.
90. Tomaz, C. and Graeff, F.G., Special issue: emotion and memory, Behav. Brain Res., 58 (1993) 1-216.
91. Vogt, B.A., Sikes, R.W. and Vogt, L.J., Anterior cingulate cortex and the medial pain system. In: B.A. Vogt and M. Gabriel (Eds.), Neurobiology of Cingulate Cortex and Limbic Thalamus, Birkhäuser, Boston, MA, 1993, pp. 313-344.
92. White, J.C. and Sweet, W.H., Pain and the Neurosurgeon. A Forty-Year Experience, CC Thomas, Springfield, IL, 1969.
93. Willis, W.D.J., Cold, pain and the brain, Nature, 373 (1994) 19-20.