Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4́-[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene] bis[phenol] based on the OECD draft protocols

Archives of Toxicology

Volumn 81, Issue 11, 2007, Pages 749-757

  Yamasaki, Kanji ^a   Miyata, Katumi ^a   Muroi, Takako ^a   Ehara, Hatsune ^a   Higashihara, Nobuhiko ^a   Houshuyama, Satsuki ^a   Oshima, Hiroshi ^a   Minobe, Yasushi ^a  

^a CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

4,4 1 4 1 (4 Hydroxyphenyl) 1 methylethyl phenyl ethylidene bis phenol ; Endocrine effects; Enhanced test guideline 407; Hershberger assay; Rat; Uterotrophic assay

Indexed keywords

4,4' [1 [4 [1 (4 HYDROXYPHENYL) 1 METHYLETHYL]PHENYL]ETHYLIDENE]BIS(PHENOL); ANTIESTROGEN; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PHENOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASSAY; ATROPHY; BREAST HYPERPLASIA; CONTROLLED STUDY; CORPUS LUTEUM; ESTRUS CYCLE; FEMALE; MALE; NONHUMAN; OVARY; PERINATAL PERIOD; PRIORITY JOURNAL; RAT; RAT STRAIN; UTERUS ATROPHY; UTERUS DISEASE; VAGINA EPITHELIUM;

ALANINE TRANSAMINASE; ALKENES; ANIMALS; BIOLOGICAL ASSAY; BLOOD GLUCOSE; BLOOD PROTEINS; CHOLESTEROL; ESTRADIOL; ESTROGEN ANTAGONISTS; FEMALE; FOLLICLE STIMULATING HORMONE; LUTEINIZING HORMONE; MALE; PHENOLS; PLATELET COUNT; RATS; RATS, INBRED STRAINS; TOXICITY TESTS; TRIGLYCERIDES; UTERUS;

RATTUS;

EID: 35748982887     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0211-8     Document Type: Article

References (20)

1. Andrews P, Freyberger A, Hartmann E, Eiben R, Loof I, Schmidt U, Temerowski M, Becka M (2001) Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide. Arch Toxicol 75:65-73
2. Cho SD, Kim JH, Kim DY, Lee YS, Kang KS (2003) Pre-validation study for OECD enhanced test guideline 407 protocol by gavage for 4 weeks using propylthiouracil and tamoxifen. Toxicol Lett 144:195-204
3. Kennel P, Pallen C, Barale-Thomas E, Espuna G, Bars R (2003) Tamoxifen: 28-day oral toxicity study in the rat based on the enhanced OECD test guideline 407 to detect endocrine effects. Arch Toxicol 77:487-499
4. Kunimatsu T, Yamada T, Miyata K, Yabushita S, Seki T, Okuno Y, Matsuo M (2004) Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD guideline 407) using androgen antagonist flutamide. Toxicology 2000:77-89
5. Mellert W, Deckardt K, Walter J, Gfatter S, van Ravenzwaay B (2003) Detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the "enhanced OECD test guideline 407". Regul Toxicol Pharmacol 38:368-377
6. Miyata K, Shiraishi S, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K (2006) Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "enhanced OECD test guideline no. 407". Arch Toxicol 80:181-186
7. OECD (1999) EMSG OECD draft proposal for testing of adequacy of an enhanced OECD protocol, repeated dose (28 days) toxicity (oral) study, based on OECD 407. OECD, Paris
8. OECD (2000) OECD protocol for investigating the efficacy of the enhanced TG407 test guideline (phase 2), rationale for the investigation, and description of the protocol. OECD, Paris
9. OECD (2001) Third meeting of the validation management group for the screening and testing of endocrine disrupters (mammalian effects). OECD, Paris
10. OECD (2006) OECD 5th meeting of the validation management group for mammalian effects testing (VMG-Mammalian) of the task force on endocrine disrupters testing AND assessment. OECD, Washington
11. Okazaki K, Imazawa T, Nakamura H, Furukawa F, Nishikawa A, Hirose M (2002a) A repeated 28-day oral dose toxicity study of 17α- methyltestosterone in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 75:635-642
12. Okazaki K, Okazaki S, Nakamura H, Kitamura Y, Hatayama K, Wakabayashi S, Tsuda T, Katsumata T, Nishikawa A, Hirose M (2002b) A repeated 28-day oral dose toxicity study of genisein in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 76:553-559
13. Okazaki K, Okazaki S, Nishimura S, Nakamura H, Kitamura Y, Hatayama K, Nakamura A, Tsuda T, Katsumata T, Nishikawa A, Hirose M (2001) A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 75:513-521
14. Shin JH, Moon HJ, Kim TS, Kang IH, Ki HY, Choi KS, Han SY (2006) Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "enhanced OECD test guideline no. 407" to detect endocrine effects. Arch Toxicol 80:547-554
15. Shiraishi K, Miyata K, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K (2006) Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407". Arch Toxicol 80:10-16
16. Toyoda K, Shibuntani M, Tamaru T, Koujitani T, Uneyama C, Hirose M (2000) Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'enhanced OECD test guideline 407' for screening for endocrine-disrupting chemicals. Arch Toxicol 74:127-132
17. Wason S, Pohlmeyer-Esch G, Pallen C, Palazzi X, Espina G, Bars R (2003) 17α-methyltestosterone: 28-day oral toxicity study in the rat based on the "enhanced OECD test guideline 407" to detect endocrine effects. Toxicology 192:119-137
18. Yamasaki K, Noda N, Imatanaka N, Yakabe Y (2004) Comparative study of the uterotrophic potency of fourteen chemicals in a uterotrophic assay and their receptor-binding affinity. Toxicol Lett 146:111-120
19. Yamasaki K, Tago Y, Nagai K, Sawaki M, Noda S, Takatsuki M (2002a) Comparison of toxicity studies based on the draft protocol for the "enhanced OECD test guideline no. 407" and the research protocol of "pubertal development and thyroid function in immature male rats" with 6-n-propyl-2-thiouracil. Arch Toxicol 76:495-501
20. Yamasaki K, Sawaki M, Noda S, Imatanaka M, Takatsuki M (2002b) Subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the "enhanced OECD test guideline no. 407". Arch Toxicol 76:65-74