Genetic background of anticyclic citrullinated peptide autoantibody production in Hungarian patients with rheumatoid arthritis

Annals of the New York Academy of Sciences

Volumn 1110, Issue , 2007, Pages 23-32

  Poór, Gyula ^a,b   Nagy, Zsolt B ^a,b   Schmidt, Zsuzsanna ^a   Brózik, Márta ^a   Merétey, Katalin ^a   Gergely Jr , Péter ^a,b  

^a NATIONAL INSTITUTE OF RHEUMATOLOGY AND PHYSIOTHERAPY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Anti CCP; HLA DRB1; PADI4; Rheumatoid arthritis; Shared epitope

Indexed keywords

ANTICYCLIC CITRULLINATED PEPTIDE; ARGININE; HLA DR ANTIGEN; PEPTIDE ANTIBODY; PEPTIDYLARGININE DEIMINASE 4; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ANTIBODY PRODUCTION; CONFERENCE PAPER; DISEASE ASSOCIATION; DNA SEQUENCE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE FREQUENCY; GENOTYPE; HEREDITY; HETEROZYGOTE DETECTION; HUMAN; HUNGARY; MAJOR CLINICAL STUDY; MALE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 35748975672     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1423.004     Document Type: Conference Paper

References (27)

1. SUZUKI, A., R. YAMADA, X. CHANG, et al. 2003. Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nat. Genet. 34: 395-402.
2. AVOUAC J., L. GOSSEC & M. DOUGADOS. 2006. Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann. Rheum. Dis. 65: 845-851.
3. LUNDBERG, K., S. NIJENHUIS, E.R. VOSSENAAR, et al. 2005. Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity. Arthritis Res. Ther. 7: R458-R467.
4. VAN DER HELM-VAN MIL, A.H., K.N. VERPOORT, F.C. BREEDVELD, et al. 2006. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum. 54: 1117-1121.
5. HUIZINGA, T.W., C.I. AMOS, A.H. VAN DER HELM-VAN MIL, et al. 2005. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum. 52: 3433-3438.
6. IKARI, K., M. KUWAHARA, T. NAKAMURA, et al. 2005. Association between PADI4 and rheumatoid arthritis: a replication study. Arthritis Rheum. 52: 3054-3057.
7. KANG, C.P., H.S. LEE, H. JU, et al. 2006. A functional haplotype of the PADI4 gene associated with increased rheumatoid arthritis susceptibility in Koreans. Arthritis Rheum. 54: 90-96.
8. HOPPE, B., T. HAUPL, R. GRUBER, et al. 2006. Detailed analysis of the variability of peptidylarginine deiminase type 4 in German patients with rheumatoid arthritis: a case-control study. Arthritis Res. Ther. 8: R34.
9. MARTINEZ, A., A. VALDIVIA, D. PASCUAL- SALCEDO, et al. 2005. PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population. Rheumatology (Oxford). 44: 1263-1266.
10. CAPONI, L., E. PETIT-TEIXEIRA, M. SEBBAG, et al. 2005. A family based study shows no association between rheumatoid arthritis and the PADI4 gene in awhite French population. Ann. Rheum. Dis. 64: 587-593.
11. HARNEY, S.M., C. MEISEL, A.M. SIMS, et al. 2005. Genetic and genomic studies of PADI4 in rheumatoid arthritis. Rheumatology (Oxford) 44: 869-872.
12. BARTON, A., J. BOWES, S. EYRE, et al. 2004. A functional haplotype of the PADI4 gene associated with rheumatoid arthritis in a Japanese population is not associated in a United Kingdom population. Arthritis Rheum. 50: 1117-1121.
13. PLENGE, R.M., L. PADYUKOV, E.F. REMMERS, et al. 2005. Replication of putative candidate-gene associations with rheumatoid arthritis in >4,000 samples from North America and Sweden: association of susceptibility with PTPN22, CTLA4, and PADI4. Am. J. Hum. Genet. 77: 1044-1060.
14. ARNETT, F.C., S.M. EDWORTHY, D.A. BLOCH, et al. 1988. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 31: 315-324.
15. CANTAERT, T., L. DE RYCKE, T. BONGARTZ, et al. 2006. Citrullinated proteins in rheumatoid arthritis: crucial. . .but not sufficient! Arthritis Rheum. 54: 3381-3389.
16. CHANG, X., R. YAMADA, A. SUZUKI, et al. 2005. Citrullination of fibronectin in rheumatoid arthritis synovial tissue. Rheumatology (Oxford) 44: 1374-1382.
17. VOSSENAAR, E.R., T.R. RADSTAKE, A. VAN DER HEIJDEN, et al. 2004. Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann. Rheum. Dis. 63: 373-381.
18. IWAMOTO, T., K. IKARI, T. NAKAMURA, et al. 2006. Association between PADI4 and rheumatoid arthritis: a meta-analysis. Rheumatology (Oxford) 45: 804-807.
19. HILL, J.A., S. SOUTHWOOD, A. SETTE, et al. 2003. Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule. J. Immunol. 171: 538-541.
20. VAN DER HELM-VAN MIL, A.H., K.N. VERPOORT, S. LE CESSIE, et al. 2007. The HLA-DRB1 shared epitope alleles differ in the interaction with smoking and predisposition to antibodies to cyclic citrullinated peptide. Arthritis Rheum. 56: 425-432.
21. KLARESKOG, L., P. STOLT, K. LUNDBERG, et al. 2006. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum. 54: 38-46.
22. TELLER, K., L. BUDHAI, M. ZHANG, et al. 1996. HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the "shared epitope" hypothesis may not apply. J. Rheumatol. 23: 1363-1368.
23. KAPITANY, A., E.ZILAHI, S. SZANTO, et al. 2005. Association of rheumatoid arthritis with HLA-DR1 and HLA-DR4 in Hungary. Ann. N. Y. Acad. Sci. 1051: 263-270.
24. VARGA, E., E. PALKONYAI, P. TEMESVARI, et al. 2003. The role of HLA-DRB1*04 alleles and their association with HLA-DQB genes in genetic susceptibility to rheumatoid arthritis in Hungarian patients. Acta Microbiol. Immunol. Hung. 50: 33-41.
25. ROJKOVICH, B. & G. POOR. 2002. Prognostic factors in rheumatoid arthritis. Orv. Hetil. 143: 2019-2026.
26. SCHMIDT, Z., A. BLAZSEK, M. BRÓZIK, et al. 2006. Lack of anti-cyclic citrullinated peptide autoantibody and HLA-DRB1*0401 might partly explain the benign synovitis in polymyalgia rheumatica [abstract]. Ann. Rheum. Dis. 65(Suppl II): 71.
27. LIGEIRO, D., J.E. FONSECA, O. ABADE, et al. 2007. Influence of human leucocyte antigen-DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti-cyclic citrullinated peptide antibodies in a Portuguese population. Ann. Rheum. Dis. 66: 246-248.