Influence of human leucocyte antigen-DRB1 on the susceptibility to rheumatoid arthritis and on the production of anti-cyclic citrullinated peptide antibodies in a Portuguese population

Annals of the Rheumatic Diseases

Volumn 66, Issue 2, 2007, Pages 246-248

  Ligeiro, D ^a   Fonseca, J E ^b,e   Abade, O ^a   Abreu, I ^d   Cruz, M ^c   Nero, P ^c   Cavaleiro, J ^b   Teles, J ^b   Trindade, H ^a   Caetano, J M ^d   Branco, J ^c  

^a Ministerio da Saude Portuguese   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR JOÃO LOBO ANTUNES   (Portugal)

^c HOSPITAL EGAS MONIZ   (Portugal)

^d NOVA MEDICAL SCHOOL   (Portugal)

^e INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GENOMIC DNA; LEUKOCYTE ANTIGEN; PEPTIDE ANTIBODY;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE; GENE EXPRESSION; GENOTYPE; HLA DRB1 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PORTUGAL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; CASE-CONTROL STUDIES; DISEASE SUSCEPTIBILITY; EPITOPES; FEMALE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; IMMUNOPHENOTYPING; MALE; MIDDLE AGED; ODDS RATIO; PEPTIDES, CYCLIC; PORTUGAL; RISK;

EID: 33846885041     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2005.051177     Document Type: Article

References (15)

1. Silman AJ, MacGregor AJ, Thomson W, Holligan S, Carthy D, Farhan A, et al. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol 1993;32:903-7.
2. Aho K, Koskenvuo M, Tuominen J, Kaprio J. Occurrence of rheumatoid arthritis in a nationwide series of twins. J Rheumatol 1986;13:899-902.
3. Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36:178-82.
4. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
5. Gonzalez-Gay MA, Garcia-Porrua C, Hajeer AH. Influence of human leukocyte antigen-DRB1 on the susceptibility and severity of rheumatoid arthritis. Semin Arthritis Rheum 2002;31:355-60.
6. Drosos AA, Lanchbury JS, Panayi GS, Moutsopoulos HM. rheumatoid arthritis in Greek and British patients. A comparative clinical, radiologic and serologic study. Arthritis Rheum 1992;35:745-8.
7. Fonseca JE, Canhao H, Costa Dias F, Leandro MJ, Resende C, Teixeira da Costa JC, et al. Severity of rheumatoid arthritis in Portuguese patients: comment on the article by Drosos et al and on the letter by Ronda et al. Arthritis Rheum 2000;43:470-2.
8. Queiroz MV, Sancho MRH, Caetano M. HLA-DR4 antigen and IgM rheumatoid factors. J Rheumatol 1982;9:370-3.
9. Van Gaalen FA, van Aken J, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum 2004;50:2113-21.
10. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
11. Rinco I, Battaarano DF, Arroyo RNA, Murphy FT, Fischbach M, Escalante A. Ethnic variation in the clinical manifestations of rheumatoid arthritis: role of HLA-DRB1 alleles. Arthritis Rheum 2003;49:200- 8.
12. Huizinga TW, Amos CI, van der Helm-van Mil AH, Chen W, van Gaalen FA, Jawaheer D, et al. Refining the complex rheumatoid arthritis phenolype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005;52:3433-8.
13. Van Gaalen FA, Linn-Rasker SP, van Venrooij WJ, de Jong BA, Breedveld FC, Verweij CL, et al. Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study. Arthritis Rheum 2004;50:709-15.
14. Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003;48:2741-9.
15. Hill JA, Southwood S, Sette A, Jevnikar AM, Bell DA, Cairns E. The conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLADRB1*0401 MHC class II molecule. J Immunol 2003;171:538-41.