The ocular surface: The challenge to enable and protect vision. The Friedenwald lecture

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 10, 2007, Pages 4391-4398

  Gipson, Ilene K ^a,b  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUCIN; MUCIN 1; MUCIN 16; MUCIN 2; MUCIN 3; MUCIN 4; MUCIN 5AC; UNCLASSIFIED DRUG;

CONFERENCE PAPER; CONJUNCTIVA; CONJUNCTIVA EPITHELIUM; CORNEA; CORNEA EPITHELIUM; DRY EYE; EYE REFRACTION; FUNCTIONAL PROTEOMICS; KERATINIZATION; LACRIMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINOL DEFICIENCY; TEAR FILM; VISION; ANIMAL; AWARDS AND PRIZES; HUMAN; LACRIMAL FLUID; MEDICAL SOCIETY; OPHTHALMOLOGY; PHYSIOLOGY; REVIEW; VISUAL SYSTEM FUNCTION;

ANIMALS; AWARDS AND PRIZES; CORNEA; HUMANS; MUCINS; OCULAR PHYSIOLOGY; OPHTHALMOLOGY; SOCIETIES, MEDICAL; TEARS; VISION;

EID: 35748966439     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.07-0770     Document Type: Conference Paper

References (56)

1. Research in dry eye: Report of the Research Subcommittee of the International Dry Eye Workshop in: Report of the International Dry Eye Workshop (DEWS). Ocul Surf. 2007;5:179-193.
2. Williams K, Watsky M. Gap junctional communication in the human corneal endothelium and epithelium. Curr Eye Res. 2002;25:29-36.
3. Walcott B, Moore LC, Birzgalis A, et al. Role of gap junctions in fluid secretion of lacrimal glands. Am J Physiol. 2002;282:C501-C507.
4. Kinoshita S, Adachi W, Sotozono C, et al. Characteristics of the human ocular surface epithelium. Prog Retin Eye Res. 2001;20:639-673.
5. Paulsen FP, Schaudig U, Thale AB. Drainage of tears: impact on the ocular surface and lacrimal system. Ocul Surf. 2003;1:180-191.
6. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
7. Fang Y, Choi D, Searles RP, Mathers WD. A time course microarray study of gene expression in the mouse lacrimal gland after acute corneal trauma. Invest Ophthalmol Vis Sci. 2005;46:461-469.
8. Report of the International Dry Eye Workshop (DEWS). Ocul Surf. 2007;5:67-202.
9. Spurr-Michaud S, Argüeso P, Gipson I. Assay of mucins in human tear fluid. Exp Eye Res. 2007;84:939-950.
10. Gipson IK, Hori Y, Argüeso P. Character of ocular surface mucins and their alteration in dry eye disease. Ocul Surf. 2004;2:131-148.
11. Gipson IK. Distribution of mucins at the ocular surface. Exp Eye Res. 2004;78:379-388.
12. Gipson I, Argüeso P. The role of mucins in the function of the corneal and conjunctival epithelia. Int Rev Cytol. 2003;231:1-49.
13. Gipson IK, Grill SM, Spurr SJ, Brennan SJ. Hemidesmosome formation in vitro. J Cell Biol. 1983;97:849-857.
14. Fujikawa LS, Foster CS, Gipson IK, Colvin RB. Basement membrane components in healing rabbit corneal epithelial wounds: immunofluorescence and ultrastructural studies. J Cell Biol. 1984;98:128-138.
15. Gipson IK, Kiorpes TC, Brennan SJ. Epithelial sheet movement: effects of tunicamycin on migration and glycoprotein synthesis. Dev Biol. 1984;101:212-220.
16. Trinkaus-Randall V, Gipson IK. Role of calcium and calmodulin in hemidesmosome formation in vitro. J Cell Biol. 1984;98:1565-1571.
17. Zieske JD, Gipson IK. Protein synthesis during corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 1986;27:1-7.
18. Gipson IK, Spurr-Michaud SJ, Tisdale AS. Hemidesmosomes and anchoring fibril collagen appear synchronously during development and wound healing. Dev Biol. 1988;126:253-262.
19. Zieske JD, Bukusoglu G, Gipson IK. Enhancement of vinculin synthesis by migrating stratified squamous epithelium. J Cell Biol. 1989;109:571.
20. Azar DT, Spurr-Michaud SJ, Tisdale AS, Gipson IK. Decreased penetration of anchoring fibrils into the diabetic stroma: a morphometric analysis. Arch Ophthalmol. 1989;107:1520-1523.
21. Stepp MA, Spurr-Michaud S, Tisdale A, Elwell J, Gipson IK. Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. Proc Natl Acad Sci USA. 1990;87:8970-8974.
22. Azar DT, Spurr-Michaud SJ, Tisdale AS, Moore MB, Gipson IK. Reassembly of the corneal epithelial adhesion structures following human epikeratoplasty. Arch Ophthalmol. 1991;109:1279-1284.
23. Azar DT, Spurr-Michaud SJ, Tisdale AS, Gipson IK. Altered epithelial-basement membrane interactions in diabetic corneas. Arch Ophthalmol. 1992;110:537-540.
24. Danjo Y, Gipson IK. Actin "purse string" filaments are anchored by E-cadherin-mediated adherens junctions at the leading edge of the epithelial wound, providing coordinated cell movement. J Cell Sci. 1998;111:3323-3332.
25. Danjo Y, Gipson IK. Specific transduction of the leading edge cells of migrating epithelia demonstrates that they are replaced during healing. Exp Eye Res. 2002;74:199-204.
26. Gipson IK, Anderson RA. Effect of lectins on migration of the corneal epithelium. Invest Ophthalmol Vis Sci. 1980;19:341-349.
27. Gipson IK, Kiorpes TC. Epithelial sheet movement: protein and glycoprotein synthesis. Dev Biol. 1982;92:259-262.
28. Gipson IK, Spurr-Michaud SJ, Tisdale AS, Kublin C, Cintron C, Keutmann H. Stratified squamous epithelia produce mucin-like glycoproteins. Tissue Cell. 1995;27:397-404.
29. Watanabe H, Fabricant M, Tisdale AS, Spurr-Michaud SJ, Lindberg K, Gipson IK. Human corneal and conjunctival epithelia produce a mucin-like glycoprotein for the apical surface. Invest Ophthalmol Vis Sci. 1995;36:337-344.
30. Danjo Y, Watanabe H, Tisdale AS, et al. Alteration of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci. 1998;39:2602-2609.
31. Gendler SJ, Spicer AP. Epithelial mucin genes. Annu Rev Physiol. 1995;57:607-634.
32. Hollingsworth MA, Swanson BJ. Mucins in cancer: protection and control of the cell surface. Nat Rev Cancer. 2004;4:45-60.
33. Moniaux N, Escande F, Porchet N, Aubert JP, Batra SK. Structural organization and classification of the human mucin genes. Front Biosci. 2001;6:D1192-D1206.
34. Situ H, Wei G, Smith CJ, Mashhoon S, Bobek LA. Human salivary MUC7 mucin peptides: effect of size, charge and cysteine residues on antifungal activity. Biochem J. 2003;375:175-182.
35. Singh PK, Hollingsworth MA. Cell surface-associated mucins in signal transduction. Trends Cell Biol. 2006;16:467-476.
36. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37:1684-1692.
37. Inatomi T, Spurr-Michaud S, Tisdale AS, Gipson IK. Human corneal and conjunctival epithelia express MUC1 mucin. Invest Ophthalmol Vis Sci. 1995;36:1818-1827.
38. Gipson IK, Spurr-Michaud S, Argüeso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci. 2003;44:2496-2506.
39. Argüeso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2002;43:1004-1011.
40. Lloyd KO, Yin BW. Synthesis and secretion of the ovarian cancer antigen CA 125 by the human cancer cell line NIH:OVCAR-3. Tumour Biol. 2001;22:77-82.
41. Argüeso P, Spurr-Michaud S, Russo CL, Tisdale A, Gipson IK. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci. 2003;44:2487-2495.
42. Argüeso P, Sumiyoshi M. Characterization of a carbohydrate epitope defined by the monoclonal antibody H185: sialic acid O-acetylation on epithelial cell-surface mucins. Glycobiology. 2006;16:1219-1228.
43. Jumblatt MM, McKenzie RW, Steele PS, Emberts CG, Jumblatt JE. MUC7 Expression in the human lacrimal gland and conjunctiva. Cornea. 2003;22:41-45.
44. McKenzie RW, Jumblatt JE, Jumblatt MM. Quantification of MUC2 and MUC5AC transcripts in human conjunctiva. Invest Ophthalmol Vis Sci. 2000;41:703-708.
45. Jager K, Wu G, Sel S, Garreis F, Brauer L, Paulsen FP. MUC16 in the lacrimal apparatus. Histochem Cell Biol. 2007;127:433-438.
46. Hori Y, Spurr-Michaud S, Russo C, Argüeso P, Gipson I. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci. 2004;45:114-122.
47. 2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005;46:4050-4061.
48. Blalock T, Spurr-Michaud S, Tisdale A, et al. Functions of MUC16 in corneal epithelial cells. Invest Ophthalmol Vis Sci. 2007;48:4509-4518.
49. Inatomi T, Tisdale AS, Zhan Q, Spurr-Michaud S, Gipson IK. Cloning of rat Muc5AC mucin gene: comparison of its structure and tissue distribution to that of human and mouse homologues. Biochem Biophys Res Commun. 1997;236:789-797.
50. Danjo Y, Hazlett LD, Gipson IK. C57BL/6 mice lacking Muc1 show no ocular surface phenotype. Invest Ophthalmol Vis Sci. 2000;41: 4080-4084.
51. Kunert KS, Keane-Myers AM, Spurr-Michaud S, Tisdale AS, Gipson IK. Alteration in goblet cell numbers and mucin gene expression in a mouse model of allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2001;42:2483-2489.
52. Tei M, Moccia R, Gipson IK. Developmental expression of mucin genes ASGP (rMuc4) and rMuc5AC by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci. 1999;40:1944-1951.
53. Tei M, Spurr-Michaud SJ, Tisdale AS, Gipson IK. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci. 2000;41:82-88.
54. Li YC, Amling M, Pirro AE, et al. Normalization of mineral ion homeostasis by dietary means prevents hyperparathyroidism, rickets, and osteomalacia, but not alopecia in vitamin D receptor-ablated mice. Endocrinology. 1998;139:4391-4396.
55. Paz HB, Tisdale AS, Danjo Y, Spurr-Michaud SJ, Argüeso P, Gipson IK. The role of calcium in mucin packaging within goblet cells. Exp Eye Res. 2003;77:69-75.
56. Lange C, Fernandez J, Shim D, Spurr-Michaud S, Tisdale A, Gipson IK. Mucin gene expression is not regulated by estrogen and/or progesterone in the ocular surface epithelia of mice. Exp Eye Res. 2003;77:59-68.