Forward genetic screen of mouse reveals dominant missense mutation in the P/Q-type voltage-dependent calcium channel, CACNA1A

Genes, Brain and Behavior

Volumn 6, Issue 8, 2007, Pages 717-727

  Xie, G ^a   Clapcote, S J ^a   Nieman, B J ^b   Tallerico, T ^c   Huang, Y ^c   Vukobradovic, I ^a   Cordes, S P ^a,c   Osborne, L R ^c   Rossant, J ^b,c   Sled, J G ^b,c   Henderson, J T ^d   Roder, J C ^a,c  

^a MOUNT SINAI HOSPITAL   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cerebellar ataxia; Dominant mutation; ENU; Genetic mapping; P Q type calcium channel

Indexed keywords

AMINO ACID; ARGININE; CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE; ETHYLNITROSOUREA; LEUCINE; MESSENGER RNA; MOLECULAR LAYER; VOLTAGE GATED CALCIUM CHANNEL;

ALLELE; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; BEHAVIOR; CELL SIZE; CEREBELLAR ATAXIA; CEREBELLUM; CEREBELLUM ATROPHY; CONTROLLED STUDY; DISEASE COURSE; FAMILIAL HEMIPLEGIC MIGRAINE; FEMALE; GENE MAPPING; GENE MUTATION; GENETIC IDENTIFICATION; GENETIC SCREENING; GRANULE CELL; HETEROZYGOSITY; HOMOZYGOTE; LIFESPAN; MALE; MISSENSE MUTATION; MOLECULAR CLONING; MOUSE; MOUSE MUTANT; MUTAGENESIS; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PERINATAL PERIOD; PREMATURITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PURKINJE CELL; REAL TIME POLYMERASE CHAIN REACTION; RIGHTING REFLEX;

AMINO ACID SUBSTITUTION; ANIMALS; ATAXIA; ATROPHY; CALCIUM CHANNELS, P-TYPE; CALCIUM CHANNELS, Q-TYPE; CEREBELLUM; DYSTONIA; FEMALE; GAIT; GENES, DOMINANT; MALE; MICE; MICE, INBRED C3H; MICE, MUTANT STRAINS; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EPICOCCUM; MUS;

EID: 35748965269     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2007.00302.x     Document Type: Article

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