Comparative drug release studies of two cationic drugs from pH-responsive nanogels

European Journal of Pharmaceutical Sciences

Volumn 32, Issue 4-5, 2007, Pages 340-348

  Tan, Jeremy P K ^a   Goh, Chew H ^a   Tam, Kam C ^b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Drug selective electrode; Imipramine hydrochloride; In vitro release; Methacrylic acid; pH responsive nanogels; Procaine hydrochloride

Indexed keywords

CATION; IMIPRAMINE; METHACRYLIC ACID DERIVATIVE; METHACRYLIC ACID ETHYL ACRYLATE; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIALLYL ESTER; PROCAINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STRUCTURE; ELECTRODE; HYDROGEN BOND; HYDROPHOBICITY; PH; PRIORITY JOURNAL;

ACRYLATES; CALORIMETRY; CATIONS; DRUG DELIVERY SYSTEMS; ELECTRODES; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; IMIPRAMINE; METHACRYLATES; MOLECULAR STRUCTURE; PHTHALIC ACIDS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; POLYMERS; PROCAINE; SOLUBILITY; TIME FACTORS;

EID: 35748953744     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2007.08.010     Document Type: Article

References (22)

1. Bruce A., Bray D., Lewis J., Raff M., Roberts K., and Watson J.D. Molecular Biology of the Cell (1994), Garland, New York
2. Foss A.C., Goto T., Morishita M., and Peppas N.A. Development of acrylic-based copolymers for oral insulin delivery. Eur. J. Pharm. Biopharm. 57 (2004) 163-169
3. Funasaki N., and Hada S. Coexistence of two kinds of mixed micelles. J. Phys. Chem. 84 (1980) 736-744
4. Govender T., Stolnik S., Garnett M.C., Illum L., and Davis S.S. PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. J. Control. Release 57 (1999) 171-185
5. Horak D., Rittich B., Safar J., Spanova A., Lenfels J., and Benes M.J. Properties of RNase A immobilized on magnetic poly (2-hedroxyl methacrylate) microspheres. Biotechnol. Prog. 17 (2001) 447-452
6. Huang L., and Somasundaran P. Changes in micelles compositions and monomer concentrations in mixed surfactant solutions. Langmuir 9 (1993) 5790-5795
7. Kim B., and Peppas N.A. In vitro release behavior and stability of insulin in complexation hydrogels as oral drug delivery carriers. Int. J. Pharm. 266 (2003) 29-37
8. Kurkuri M.D., and Aminabhavi T.M. Poly(vinyl alcohol) and poly(acrylic acid) sequential interpenetrating network pH-sensitive microspheres for the delivery of diclofenac sodium to the intestine. J. Control. Release 96 (2004) 9-20
9. Langer R. Drug delivery: drugs on target. Science 293 (2001) 58-59
10. Lopez V.C., Hadgraft J., and Snowden M.J. The use of colloidal microgels as a transdermal drug delivery system. Int. J. Pharm. 292 (2005) 137-147
11. Lowman A.M., Morishita M., Kajita M., Nagai T., and Peppas N.A. Oral delivery of insulin using pH-responsive complexation gels. J. Pharm. Sci. 88 (1999) 933-937
12. Madeline T.L., and Peppas N.A. Molecular design and in vitro studies of novel pH-sensitive hydrogels for the oral delivery of calcitonin. Macromolecules 32 (1999) 6646-6651
13. Makayssi A., Lemordant D., and Treiner C. Structural change and micellar composition in aqueous solution of binary cationic surfactant mixtures as deduced from cross-flow ultrafiltration experiments. Langmuir 9 (1993) 2808-2813
14. Mathiowitz E. Encyclopedia of Controlled Drug Delivery (1999), John Wiley and Sons
15. Morishita M., Lowman A.M., Takayama K., Nagai T., and Peppas N.A. Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers. J. Control. Release 81 (2002) 25-32
16. Pillay V., and Fassihi R. In vitro release modulation from crosslinked pellets for site-specific drug delivery to the gastrointestinal tract. I. Comparison of pH-responsive drug release and associated kinetics. J. Control. Release 59 (1999) 229-242
17. Soppimath K.S., Kulkarni A.R., and Aminabhavi T.M. Chemically modified polyacrylamide-g-guar gum-based crosslinked anionic microgels as pH-sensitive drug delivery systems: preparation and characterization. J. Control. Release 75 (2001) 331-345
18. Sutani K., Kaetsu I., Uchida K., and Matsubara Y. Stimulus responsive drug release from polymer gel. Controlled release of ionic drug from polyampholyte gel. Radiat. Phys. Chem. 64 (2002) 331-336
19. Tan J.P.K., and Tam K.C. Application of drug selective electrode in the drug release study of pH-responsive microgels. J. Control. Release 118 (2007) 87-94
20. Yang M., Cui F., You B., Wang L., Yue P., and Kawashima Y. A novel pH-dependent gradient-release delivery system for nitrendipine. II. Investigations of the factors affecting the release behaviors of the system. Int. J. Pharm. 286 (2004) 99-109
21. Wang C., and Tam K.C. New insights on the interaction mechanism within oppositely charged polymer/surfactant systems. Langmuir 18 (2002) 6484-6490
22. Warr G.G., Grieser F., and Healy T.W. Composition of mixed micelles of polydisperse nonionic surfactants. J. Phys. Chem. 87 (1983) 1220-1223