Role of proteasomes in the formation of neurofilamentous inclusions in spinal motor neurons of aluminum-treated rabbits

Neuropathology

Volumn 27, Issue 6, 2007, Pages 522-530

  Kimura, Noriyuki ^a   Kumamoto, Toshihide ^a   Ueyama, Hidetsugu ^a   Horinouchi, Hideo ^a   Ohama, Eisaku ^b  

^a OITA UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Aluminum intoxication; Neurofilament degradation; Neurofilamentous inclusion; Proteasome; Spinal motor neuron

Indexed keywords

ALUMINUM; NEUROFILAMENT H PROTEIN; NEUROFILAMENT PROTEIN; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CELL INCLUSION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; LUMBAR SPINE; MALE; MOLECULAR WEIGHT; NERVE DEGENERATION; NEUROFILAMENT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; RABBIT; SPINAL CORD MOTONEURON; WESTERN BLOTTING;

ALUMINUM; ANIMALS; BLOTTING, WESTERN; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; MALE; MOTOR NEURONS; NEUROFILAMENT PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; RABBITS; SPINAL CORD;

EID: 35748950974     PISSN: 09196544     EISSN: 14401789     Source Type: Journal    
DOI: 10.1111/j.1440-1789.2007.00822.x     Document Type: Article

References (38)

1. Munoz DG, Greene C, Perl DP, Selkoe DJ. Accumulation of phosphorylated neurofilaments in anterior horn motoneurons of amyotrophic lateral sclerosis patients. J Neuropathol Exp Neurol 1988 47 : 9 18.
2. Sobue G, Hashizume Y, Yasuda T et al. Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells. Acta Neuropathol 1990 79 : 402 408.
3. Katsetos CD, Savory J, Herman MM et al. Neuronal cytoskeletal lesions induced in the CNS by intraventricular and intravenous aluminium maltol in rabbits. Neuropathol Appl Neurobiol 1990 16 : 511 528.
4. Parhad IM, Krekoski CA, Mathew A, Tran PM. Neuronal gene expression in aluminum myelopathy. Cell Mol Neurobiol 1989 9 : 123 138.
5. Strong MJ, Jakowec DM. 200 kDa and 160 kDa neurofilament protein phosphatase resistance following in vivo aluminum chloride exposure. Neurotoxicology 1994 15 : 799 807.
6. Strong MJ, Mao K, Nerurkar VR, Wakayama I, Yanagihara R, Garruto RM. Dose-dependent selective suppression of light (NFL) and medium (NFM) but not heavy (NFH) molecular weight neurofilament mRNA levels in acute aluminum neurotoxicity. Mol Cell Neurosci 1994 5 : 319 326.
7. Takeda M, Tatebayashi Y, Tanimukai S, Nakamura Y, Tanaka T, Nishimura T. Immunohistochemical study of microtubule-associated protein 2 and ubiquitin in chronically aluminum-intoxicated rabbit brain. Acta Neuropathol 1991 82 : 346 352.
8. Gotow T, Tanaka J, Takeda M. The organization of neurofilaments accumulated in perikaryon following aluminum administration: relationship between structure and phosphorylation of neurofilaments. Neuroscience 1995 64 : 553 569.
9. Klatzo I, Wisniewski H, Streicher E. Experimental production of neurofibrillary degeneration. 1. Light microscopic observation. J Neuropathol Exp Neurol 1965 24 : 187 199.
10. Terry RD, Pena C. Experimental production of neurofibrillary degeneration 2. Electron microscopy, phosphatase histochemistry and electron probe analysis. J Neuropathol Exp Neurol 1965 24 : 200 210.
11. Johnson GV, Jope RS. Phosphorylation of rat brain cytoskeletal proteins is increased after orally administered aluminum. Brain Res 1988 456 : 95 103.
12. Bizzi A, Gambetti P. Phosphorylation of neurofilaments is altered in aluminium intoxication. Acta Neuropathol 1986 71 : 154 158.
13. Strong MJ, Garruto RM. Neuron-specific thresholds of aluminum toxicity in vitro: a comparative analysis of dissociated fetal rabbit hippocampal and motor neuron-enriched cultures. Lab Invest 1991 65 : 243 249.
14. Troncoso JC, Hoffman PN, Griffin JW, Hess-Kozlow KM, Price DL. Aluminum intoxication: a disorder of neurofilament transport in motor neurons. Brain Res 1985 342 : 172 175.
15. Shea TB, Wheeler E, Jung C. Aluminum inhibits neurofilament assembly, cytoskeletal incorporation, and axonal transport. Dynamic nature of aluminium-induced perikaryal neurofilament accumulations as revealed by subunit turnover. Mol Chem Neuropathol 1997 32 : 17 39.
16. Nixon RA, Clarke JF, Logvinenko KB, Tan MK, Hoult M, Grynspan F. Aluminum inhibits calpain-mediated proteolysis and induces human neurofilament proteins to form protease-resistant high molecular weight complexes. J Neurochem 1990 55 : 1950 1959.
17. Shea TB, Balikian P, Beermann ML. Aluminum inhibits neurofilament protein degradation by multiple cytoskeleton-associated proteases. FEBS Lett 1992 307 : 195 198.
18. Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem 1996 65 : 801 847.
19. Tanaka K, Chiba T. The proteasome: a protein-destroying machine. Genes Cells 1998 3 : 499 510.
20. Ding Q, Keller JN. Proteasomes and proteasome inhibition in the central nervous system. Free Radic Biol Med 2001 31 : 574 584.
21. David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG. Proteasomal degradation of tau protein. J Neurochem 2002 83 : 176 185.
22. Checler F, da Costa CA, Ancolio K, Chevallier N, Lopez-Perez E, Marambaud P. Role of the proteasome in Alzheimer's disease. Biochim Biophys Acta 2000 1502 : 133 138.
23. Tsuji S, Kikuchi S, Shinpo K et al. Proteasome inhibition induces selective motor neuron death in organotypic slice cultures. J Neurosci Res 2005 82 : 443 451.
24. Suzuki H, Takeda M, Nishimura T. Enzymatic characterization of cathepsin D in rabbit brains with experimental neurofibrillary changes. Biochem Mol Bio Int 1994 32 : 1033 1039.
25. Simpson J, Yates CM, Whyler DK, Wilson H, Dewar AJ, Gordon A. Biochemical studies on rabbits with aluminium induced neurofilament accumulations. Neurochem Res 1985 10 : 229 237.
26. Guo-Ross S, Yang E, Bondy SC. Elevation of cerebral proteases after systemic administration of aluminum. Neurochem Int 1998 33 : 277 282.
27. Yamamoto T, Hirano A. A comparative study of modified Bielschowsky Bodian and thioflavin S stains on Alzheimer's neurofibrillary tangles. Neuropathol Appl Neurobiol 1986 12 : 3 9.
28. Lowry OH, Rosenbrough NJ, Farr L, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951 193 : 265 275.
29. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970 227 : 680 685.
30. Strong MJ, Strong WL, Jaffe H, Traggert B, Sopper MM, Pant HC. Phosphorylation state of the native high-molecular-weight neurofilament subunit protein from cervical spinal cord in sporadic amyotrophic lateral sclerosis. J Neurochem 2001 76 : 1315 1325.
31. Mitch WE, Goldberg AL. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med 1996 335 : 1897 1905.
32. Suzuki H, Takeda M, Nakamura Y, Tada K, Hariguchi S, Nishimura T. Activities of lysosomal enzymes in rabbit brain with experimental neurofibrillary changes. Neurosci Lett 1988 89 : 234 239.
33. Banay-Schwartz M, Dahl D, Hui KS, Lajtha A. The breakdown of the individual neurofilament proteins by cathepsin D. Neurochem Res 1987 12 : 361 367.
34. Malik MN, Sheikh AM, Fenko MD, Wisniewski HM. Purification an degradation of purified neurofilament proteins by the brain calcium-activated neutral proteases. Life Sci 1986 39 : 1335 1343.
35. Masaki R, Saito T, Yamada K, Ohtani-Kaneko R. Accumulation of phosphorylated neurofilaments and increase in apoptosis-specific protein and phosphorylated c-Jun induced by proteasome inhibitors. J Neurosci Res 2000 62 : 75 83.
36. Benaroudj N, Tarcsa E, Cascio P, Goldberg AL. The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes. Biochimie 2001 83 : 311 318.
37. Tofaris GK, Layfield R, Spillantini MG. Alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome. FEBS Lett 2001 509 : 22 26.
38. Mengual E, Arizti P, Rodrigo J, Gimenez-Amaya JM, Castano JG. Immunohistochemical distribution and electron microscopic subcellular localization of the proteasome in the rat CNS. J Neurosci 1996 16 : 6331 6341.