Adipose tissue mass is modulated by SLUG (SNAI2)

Human Molecular Genetics

Volumn 16, Issue 23, 2007, Pages 2972-2986

  Pérez Mancera, Pedro Antonio ^a   Bermejo Rodríguez, Camino ^a   González Herrero, Inés ^a   Herranz, Michel ^a   Flores, Teresa ^b   Jiménez, Rafael ^b   Sánchez García, Isidro ^a  

^a Salamanca Spain   (Spain)

^b UNIVERSITY OF SALAMANCA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE DEACETYLASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; TRANSCRIPTION FACTOR SLUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIPID STORAGE; LIPODYSTROPHY; MALE; MOUSE; NONHUMAN; OBESITY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; WHITE ADIPOSE TISSUE;

3T3-L1 CELLS; ADIPOGENESIS; ADIPOSE TISSUE; ANIMALS; BASE SEQUENCE; DNA PRIMERS; GENE EXPRESSION; HUMANS; MICE; MICE, KNOCKOUT; ORGAN SIZE; TRANSCRIPTION FACTORS; ZINC FINGERS;

MAMMALIA; MUS;

EID: 35748948046     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddm278     Document Type: Article

References (37)

1. Morrison, R.F. and Farmer, S.R. (2000) Hormonal signaling and transcriptional control of adipocyte differentiation. J. Nutr., 130, 3116S-3121S.
2. Rosen, E.D., Walkey, C.J., Puigserver, P. and Spiegelman, B.M. (2000) Transcriptional regulation of adipogenesis. Genes Dev., 14, 1293-1307.
3. Soukas, A., Socci, N.D., Saatkamp, B.D., Novelli, S. and Friedman, J.M. (2001) Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J. Biol. Chem., 276, 34167-34174.
4. Chen, Z., Torrens, J.I., Anand, A., Spiegelman, B.M. and Friedman, J.M. (2005) Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab., 1, 93-106.
5. Sefton, M., Sanchez, S. and Nieto, M.A. (1998) Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo. Development, 125, 3111-3121.
6. Sanchez-Martin, M., Gonzalez-Herrero, I. and Sanchez-Garcia, I. (2004) SNAI2 (SNAIL HOMOLOG 2) Atlas Genet Cytogenet Oncol Haematol. http://atlasgeneticsoncology.org//Genes/SNAI2ID453.html. April.
7. Inoue, A., Seidel, M.G., Wu, W., Kamizono, S., Ferrando, A.A., Bronson, R.T., Iwasaki, H., Akashi, K., Morimoto, A., Hitzler, J.K. et al. (2002) Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell, 2, 279-288.
8. Perez-Losada, J., Sanchez-Martin, M., Rodriguez-Garcia, A., Sanchez, M.L., Orfao, A., Flores, T. and Sanchez-Garcia, I. (2002) Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood, 100, 1274-1286.
9. Perez-Losada, J., Sanchez-Martin, M., Perez-Caro, M., Perez-Mancera, P.A. and Sanchez-Garcia, I. (2003) The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene, 22, 4205-4211.
10. Pérez-Mancera, P.A., González-Herrero, I., Pérez-Caro, M., Gutierrez-Cianca, N., Flores, T., Gutierrez-Adan, A., Pintado, B., Sanchez-Martin, M. and Sanchez-Garcia, I. (2005) SLUG (SNAI2) in cancer development. Oncogene, 24, 3073-3082.
11. Cohen, M.E., Yin, M., Paznekas, W.A., Schertzer, M., Wood, S. and Jabs, E.W. (1998) Human SLUG gene organization, expression, and chromosome map location on 8q. Genomics, 51, 468-471.
12. Sanchez-Martin, M., Rodriguez-Garcia, A., Perez-Losada, J., Sagrera, A., Read, A.P. and Sanchez-Garcia, I. (2002) SLUG (SNAI2) deletions in patients with Waardenburg disease. Hum. Mol. Genet., 11, 3231-3236.
13. Oram, K.F., Carver, E.A. and Gridley, T. (2003) Slug expression during organogenesis in mice. Anat. Rec., 271A, 189-191.
14. Sanchez-Martin, M., Perez-Losada, J., Rodriguez-Garcia, A., Gonzalez-Sanchez, B., Korf, B.R., Kuster, W., Moss, C., Spritz, R.A. and Sanchez-Garcia, I. (2003) Deletion of the SLUG (SNAI2) gene results in human piebaldism. Am. J. Med. Genet., 122A, 125-132.
15. Perez-Mancera, P.A., Gonzalez-Herrero, I., Maclean, K., Turner, A.M., Yip, M.Y., Sanchez-Martin, M., Garcia, J.L., Robledo, C., Flores, T., Gutierrez-Adan, A., Pintado, B. and Sanchez-Garcia, I. (2006) SLUG (SNAI2) overexpression in embryonic development. Cytogenet. Genome Res., 114, 24-29.
16. Zhang, J., Fu, M., Cui, T., Xiong, C., Xu, K., Zhong, W., Xiao, Y., Floyd, D., Liang, J., Li, E., Song, Q. and Chen, Y.E. (2004) Selective disruption of PPARgamma 2 impairs the development of adipose tissue and insulin sensitivity. Proc. Natl Acad. Sci. USA, 101, 10703-10708.
17. Tontonoz, P., Hu, E. and Spiegelman, B.M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell, 79, 1147-1156.
18. Wu, Z., Rosen, E.D., Brun, R., Hauser, S., Adelmant, G., Troy, A.E., McKeon, C., Darlington, G.J. and Spiegelman, B.M. (1999) Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell., 3, 151-158.
19. Fajas, L., Auboeuf, D., Raspe, E., Schoonjans, K., Lefebvre, A.M., Saladin, R., Najib, J., Laville, M., Fruchart, J.C., Deeb, S. et al. (1997) The organization, promoter analysis, and expression of the human PPARgamma gene. J. Biol. Chem., 272, 18779-18789.
20. Peinado, H., Ballestar, E., Esteller, M. and Cano, A. (2004) Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell. Biol., 24, 306-319.
21. Bermejo-Rodríguez, C., Pérez-Caro, M., Pérez-Mancera, P.A., Sánchez-Beato, M., Piris, M.A. and Sánchez-García, I. (2006) Mouse cDNA microarray analysis uncovers SLUG targets in mouse embryonic fibroblasts. Genomics, 87, 113-118.
22. Ayer, D.E. (1999) Histone deacetylases: Transcriptional repression with SINers and NuRDs. Trends Cell. Biol., 19, 193-198.
23. Cao, Z., Umek, R.M. and McKnight, S.L. (1991) Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev., 5, 1538-1552.
24. Lin, F.T. and Lane, M.D. (1994) CCAAT/enhancer binding protein alpha is sufficient to initiate the 3T3-L1 adipocyte differentiation program. Proc. Natl Acad. Sci. USA, 91, 8757-8761.
25. Rosen, E.D., Hsu, C.H., Wang, X., Sakai, S., Freeman, M.W., Gonzalez, F.J. and Spiegelman, B.M. (2002) C/EBPalpha induces adipogenesis through PPARgamma: A unified pathway. Genes Dev., 16, 22-26.
26. Marks, P.A. and Jiang, X. (2005) Histone deacetylase inhibitors in programmed cell death and cancer therapy. Cell Cycle, 4, 549-551.
27. Yoo, E.J., Chung, J.J., Choe, S.S., Kim, K.H. and Kim, J.B. (2006) Down-regulation of histone deacetylases stimulates adipocyte differentiation. J. Biol. Chem., 281, 6608-6615.
28. Inukai, T., Inoue, A., Kurosawa, H., Goi, K., Shinjyo, T., Ozawa, K., Mao, M., Inaba, T. and Look, A.T. (1999) SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell, 4, 343-352.
29. Khan, J., Bittner, M.L., Saal, L.H., Teichmenn, V., Azorsa, D.O., Gooden, G.C., Pavan, W.J., Trent, J.M. and Meltzer, P.S. (1999) cDNA microarrays detect activation of a myogenic transcription program by the PAX3-FKHR fusion gene. Proc. Natl Acad. Sci. USA, 96, 13264-13269.
30. Wasserman, F. (1965) The development of adipose tissue. In Renold, A. and Cahill, G. (eds), Handbook of Physiology, Vol. Vol. 5, American Physiological Society, Washington, DC, pp. 87-100.
31. Cinti, S. (2000) Anatomy of the adipose organ. Eat. Weight Disord. 5, 132-142.
32. Cobaleda, C., Perez-Caro, M., Vicente-Dueñas, C. and Sanchez-Garcia, I. (2007) Function of zinc-finger transcription factor SNA12 in cancer and development. Annu. Rev. Genet., Epub ahead of print June 5, 2007.
33. Aybar, M.J., Nieto, M.A. and Mayor, R. (2003) Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest. Development, 130, 483-494.
34. Bolos, V., Peinado, H., Perez-Moreno, M.A., Fraga, M.F., Esteller, M. and Cano, A. (2003) The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors. J. Cell. Sci., 116 499-511.
35. Jiang, R., Lan, Y., Norton, C.R., Sundberg, J.P. and Gridley, T. (1998) The Slug gene is not essential for mesoderm or neural crest development in mice. Dev. Biol., 198, 277-285.
36. Castellanos, A., Pintado, B., Wuruaga, E., Arévalo, R., López, A., Orfao, A. and Sánchez-García, I. (1997) A BCR-ABL(p190) fusion gene made by homologous recombination causes B-cell acute lymphoblastic leukemias in chimeric mice with independence of the endogenous bcr product. Blood, 90, 2168-2174.
37. Calkhoven, C.F., Muller, C. and Lentz, A. (2000) Translational control of C/EBPalpha and C/EBPbeta isoform expression. Genes Dev., 14 1920-1932.