The expression of innate immunity genes in Italian Crohn disease patients

European Journal of Histochemistry

Volumn 51, Issue 3, 2007, Pages 199-202

  Milanese, M ^a   Segat, L ^a   Marziliano, N ^b   Crovella, Sergio ^a,c  

^a Dipartimento di Scienze della Riproduzione e dello Sviluppo   (Italy)

^b Centro Malattie Genetiche Cardiovascolari   (Italy)

^c INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

Crohn disease; DEFB1; Gene expression; Innate immunity; MBL2

Indexed keywords

MANNOSE BINDING LECTIN 2; BETA DEFENSIN; DEFB1 PROTEIN, HUMAN; MANNOSE BINDING LECTIN; MBL2 PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENDOTHELIUM CELL; GENE EXPRESSION; GENE LOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; INNATE IMMUNITY; INTESTINE BIOPSY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BASEMENT MEMBRANE; BIOSYNTHESIS; EPITHELIUM CELL; GENETICS; IMMUNOLOGY; INTESTINE MUCOSA; ITALY; METABOLISM; PATHOLOGY; POLYMERASE CHAIN REACTION;

FUNGI;

BASEMENT MEMBRANE; BETA-DEFENSINS; CROHN DISEASE; EPITHELIAL CELLS; HUMANS; IMMUNITY, NATURAL; INTESTINAL MUCOSA; ITALY; MANNOSE-BINDING LECTIN; POLYMERASE CHAIN REACTION;

EID: 35748946340     PISSN: 1121760X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (11)

1. Boniotto M, Radillo O, Braida L, Pirulli D, Citta A, Not T, et al. Detection of MBL-2 gene expression in intestinal biopsies of celiac patients by in situ reverse transcription polymerase chain reaction. Eur J Histochem 2003; 47: 177-80.
2. Dhaliwal W, Bajaj-Elliott M, Kelly P. Intestinal defensin gene expression in human populations. Mol Immunol 2003; 40: 469-75.
3. Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003; 37: 1496-505.
4. Fellermann K, Stange DE, Shaeffeler E, Schmalzl H, Wehkamp J, Bevins CL et al. A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet 2006; 79:439-48.
5. Livak KJ and Schmittgen DT. Analysis of relative gene expression data using Real Time Quantitative PCR and the 2-DDCt Method. Methods 2001; 25:402-8
6. O'Neil DA, Porter EM, Elewaut D, Anderson GM, Eckmann L, Ganz T, et al. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium. J Immunol 1999; 163: 6718-24.
7. Sands BE. Inflammatory bowel disease: past, present, and future. J Gastroenterol. 2007 1:16-25.
8. Turner MW. Mannose-binding lectin (MBL) in health and disease. Immunobiology 1998; 199: 327-39.
9. Wehkamp J, Fellermann K, Stange EF. Human defensins in Crohn disease. Chem Immunol Allergy. 2005; 86:42-54.
10. Wehkamp J, Stange EF. A new look at Crohn disease: breakdown of the mucosal antibacterial defense. Ann N Y Acad Sci 2006; 1072:321-31.
11. Yamamoto-Furusho JK, Korzenik JR. Crohn disease: innate immunodeficiency? World J Gastroenterol. 2006; 12:6751-5.