Genetic control of immune response in carriers of the 8.1 ancestral haplotype: Correlation with levels of IgG subclasses: Its relevance in the pathogenesis of autoimmune diseases

Annals of the New York Academy of Sciences

Volumn 1110, Issue , 2007, Pages 151-158

  Candore, Giuseppina ^a   Campagna, Anna Maria ^a,b   Cuppari, Irene ^a,b   Carlo, Daniele D I ^a,b   Mineo, Claudia ^a,b   Caruso, Calogero ^a,b  

^a UNIVERSITY OF PALERMO   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

AH 8.1; Autoimmune diseases; HLA B8,DR3; IgG subclasses; Immune response

Indexed keywords

ANTIGEN; ANTIINFECTIVE AGENT; AUTOANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATION FUNCTION; CROSS REACTION; FEMALE; GENETIC REGULATION; HAPLOTYPE; HETEROZYGOTE; HUMAN; IMMUNE RESPONSE; MALE; OBSERVATIONAL STUDY; PATHOGENESIS; STATISTICAL SIGNIFICANCE;

EID: 35748942904     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1423.017     Document Type: Conference Paper

References (30)

1. DAWKINS, R. et al. 1999. Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease. Immunol. Rev. 167: 275-304.
2. KLEIN, J. & A. SATO. 2000. The HLA system. N. Engl. J. Med. 343: 702-709, 782-786.
3. GRUEN, J.R. & S.M. WEISSMAN. 1997. Evolving views of the major histocompatibility complex. Blood 90: 4252-4265.
4. PRICE, P. et al.1999. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol. Rev. 167: 257-274.
5. DAVIDSON, A. & B. DIAMOND. 2001. Autoimmune diseases. N. Engl. J. Med. 345: 340-350.
6. CARUSO, C. et al.2000. HLA, aging and longevity: a critical reappraisal. Human Immunol. 61: 942-949.
7. MODICA, M.A. et al. 1993. The HLA-B8,DR3 haplotype and immune response in healthy subjects. Immunol. Infect. Dis. 3: 119-127.
8. CANDORE, G. et al. 1998. Biological basis of the HLA-B8,DR3 associated progression of acquired immune deficiency virus syndrome. Pathobiology 66: 33-37.
9. CARUSO, C. et al. 1996. Major histocompatibility complex regulation of cytokine production. J. Interferon Cytokine Res. 16: 983-988.
10. LIO, D. et al. 1997. Modification of cytokine patterns in subjects bearing the HLAB8, DR3 phenotype: implications for autoimmunity. Cytokines Cell. Mol. Ther. 3: 217-224.
11. LIO, D. et al. 2001. A genetically determined high setting of TNF-α influences immunological parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity. Human Immunol. 62: 705-713.
12. CANDORE, G. et al. 2003. Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype. Biomed. Pharmacother. 57: 274-277.
13. CANDORE, G. et al. 2002. Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions. Autoimmun. Rev. 1: 29-35.
14. MODICA, M.A. et al. 1989. Blood IgA, IgM and IgE levels are influenced by sex and HLA phenotype. Exp. Clin. Immunogenet. 6: 251-257.
15. JANEWAY, C.A., JR. et al. 2005. Immunobiology: The Immune System in Health and Disease. Sixth edition. Garland Science Publishing. Dallas, TX.
16. SIBER, G.R. et al. 1980. Correlation between serum IgG2 concentrations and the antibody response to bacterial polysaccharide antigens. N. Engl. J. Med. 303: 178-182.
17. UMETSU, D.T. et al. 1985. Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG subclass deficiency. N. Engl. J. Med. 313: 1247-1251.
18. DJURUP, R. 1985. The subclass nature and clinical significance of the IgG antibody response in patients undergoing allergen-specific immunotherapy. Allergy 40: 469-486.
19. PERELMUTTER, L. 1984. IgG4: non-IgE mediated atopic disease. Ann. Allergy 52: 64-69.
20. LIO, D. et al. 2003. Association between the HLA-DR alleles and longevity: a study in Sardinian population. Exp. Gerontol. 38: 313-318.
21. LISTÌ, F. et al. 2006. A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence. Ann. N. Y. Acad. Sci. 1089: 487-495.
22. VAN DE WINKEL, J.G. & C.L. ANDERSON. 1991. Biology of human immunoglobulin G Fc receptors. J. Leukoc. Biol. 49: 511-524.
23. THORSBY, E. 1997. HLA associated diseases. Human Immunol. 53: 1-11.
24. UNDLIEN, D.E. et al. 2001. HLA complex genes in type I diabetes and other autoimmune diseases. Which genes are involved? Trends Genet. 17: 93-100.
25. SOLLID, L.M. 2000. Molecular basis of celiac disease. Annu. Rev. Immunol. 18: 53-81.
26. CARUSO, C. et al. 1997. HLA-B8,DR3 haplotype affects lymphocyte blood levels. Immunol. Invest. 26: 333-340.
27. STASSI, G. et al. 1997. Detective expression of CD95 (FAS/APO-1) molecule suggests apoptosis impairment of T and B cells in HLA-B8,DR3-positive individuals. Hum. Immunol. 55: 39-45.
28. CANDORE, G. et al. 2006. Genetic control of immune response in carriers of ancestral haplotype 8.1: the study of chemotaxis. Ann. N. Y. Acad. Sci. 1089: 509-515.
29. SCOTT, M.G. et al. 1988. Human IgG subclasses and their relation to carbohydrate antigen immunocompetence. Diagn. Clin. Immunol. 5: 241-248.
30. LUCAS, A.H. & D.M. GRANOFF. 1995. Functional differences in idiotypically defined IgG antipolysaccharide antibodies elicited by vaccination with Haemophilus influenzae type B polysaccharide-protein conjugates. J. Immunol. 154: 4195-4202.