Minor contribution of SMAD7 and KLF10 variants to genetic susceptibility of type 2 diabetes

Diabetes and Metabolism

Volumn 33, Issue 5, 2007, Pages 372-378

  Gutierrez Aguilar, R ^a   Benmezroua, Y ^a   Balkau, B ^b   Marre, M ^b   Helbecque, N ^b   Charpentier, G ^c   Polychronakos, C ^d   Sladek, R ^d   Froguel, P ^a,e   Neve, B ^a,e  

^a INSTITUT PASTEUR DE LILLE   (France)

^b INSERM   (France)

^c CENTRE HOSPITALIER SUD FRANCILIEN   (France)

^d Genome Quebec Innovation Centre   (Canada)

^e HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Genetic variants; Kr ppel like factor 10 (KLF10); SMAD7; Type 2 diabetes

Indexed keywords

SMAD7 PROTEIN; EARLY GROWTH RESPONSE FACTOR; KLF10 PROTEIN, HUMAN; KRUPPEL LIKE FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA SEQUENCE; FEMALE; GENE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; KLF10 GENE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; SINGLE NUCLEOTIDE POLYMORPHISM; CASE CONTROL STUDY; CAUCASIAN; FRANCE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; REFERENCE VALUE;

ADULT; AGED; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; EARLY GROWTH RESPONSE TRANSCRIPTION FACTORS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FRANCE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MIDDLE AGED; REFERENCE VALUES; SMAD7 PROTEIN; VARIATION (GENETICS);

EID: 35649026337     PISSN: 12623636     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabet.2007.06.002     Document Type: Article

References (21)

1. Smart N.G., Apelqvist A.A., Gu X., Harmon E.B., Topper J.N., Macdonald R.J., et al. Conditional expression of smad7 in pancreatic beta cells disrupts TGF-Beta signaling and induces reversible diabetes mellitus. PLoS Biol. 4 (2006) (e39 Epub 2006 Jan 31)
2. Massagué J., and Chen Y.G. Controlling TGF-beta signaling. Genes Dev. 14 (2000) 627-644
3. Neve B., Fernandez-Zapico M.E., Ashkenazi-Katalan V., Dina C., Hamid Y.H., Joly E., et al. Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function. Proc. Natl. Acad. Sci. USA 102 (2005) 4807-4812
4. Fernandez-Zapico M.E., Mladek A., Ellenrieder V., Folch-Puy E., Miller L., and Urrutia R. An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation. EMBO J. 22 (2003) 4748-4758
5. Ellenrieder V., Buck A., Harth A., Jungert K., Buchholz M., Adler G., et al. KLF11 mediates a critical mechanism in TGF-beta signaling that is inactivated by Erk-MAPK in pancreatic cancer cells. Gastroenterology 127 (2004) 607-620
6. Cook T., and Urrutia R. TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (2000) G513-G521
7. Tachibana I., Imoto M., Adjei P.N., Gores G.J., Subramaniam M., Spelsberg T.C., et al. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J. Clin. Invest. 99 (1997) 2365-2374
8. Johnsen S.A., Subramaniam M., Janknecht R., and Spelsberg T.C. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene 21 (2002) 5783-5790
9. Song C.Z., Gavriilidis G., Asano H., and Stamatoyannopoulos G. Functional study of transcription factor KLF11 by targeted gene inactivation. Blood Cells Mol. Dis. 34 (2005) 53-59
10. Subramaniam M., Gorny G., Johnsen S.A., Monroe D.G., Evans G.L., Fraser D.G., et al. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol. Cell. Biol. 25 (2005) 1191-1199
11. Fumeron F., Aubert R., Siddiq A., Betoulle D., Pean F., Hadjadj S., et al. Epidemiologic Data on the Insulin Resistance Syndrome (DESIR) Study Group. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes 53 (2004) 1150-1157
12. Vasseur F., Guérardel A., Barat-Houari M., Cottel D., Amouyel P., Froguel P., et al. Impact of a CART promoter genetic variation on plasma lipid profile in a general population. Mol. Genet. Metab 90 (2007) 199-204
13. Neve B., Froguel P., Corset L., Vaillant E., Vatin V., and Boutin P. Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing. Biotechniques 32 (2002) 1138-1142
14. Gordon D., Finch S.J., Nothnagel M., and Ott J. Power and sample size calculations for case-control genetic association tests when errors present: application to single nucleotide polymorphisms. Hum. Hered. 54 (2002) 22-33
15. Mantel N., and Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer Inst. 22 (1959) 719-748
16. Cook T., Gebelein B., Belal M., Mesa K., and Urrutia R. Three conserved transcriptional repressor domains are a defining feature of the TIEG subfamily of Sp1-like zinc finger proteins. J. Biol. Chem. 274 (1999) 29500-29504
17. Sladek R., Rocheleau G., Rung J., Dina C., Shen L., Serre D., et al. A genome-wide association study identifies novel risk Loci for type 2 diabetes. Nature 445 (2007) 881-885
18. Han G., Li A.G., Liang Y.Y., Owens P., He W., Lu S., et al. Smad7-induced beta-catenin degradation alters epidermal appendage development. Dev. Cell 11 (2006) 301-312
19. Grant S.F., Thorleifsson G., Reynisdottir I., Benediktsson R., Manolescu A., Sainz J., et al. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat. Genet. 38 (2006) 320-323
20. Markham N.R., and Zuker M. DINAMelt web server for nucleic acid melting prediction. Nucleic Acids Res. 33 (2005) W577-W581
21. Florez J.C., Saxena R., Winckler W., Burtt N.P., Almgren P., Bengtsson Boström K., et al. The Krüppel-like factor 11 (KLF11) Q62R polymorphism is not associated with type 2 diabetes in 8,676 people. Diabetes 55 (2006) 3620-3624