A novel homospermidine conjugate inhibits growth and induces apoptosis in human hepatoma cells

Acta Pharmacologica Sinica

Volumn 28, Issue 11, 2007, Pages 1827-1834

  Xie, Song Qiang ^a,b   Wu, Ying Liang ^a   Cheng, Peng Fei ^b   Wang, Min Wei ^a   Liu, Guang Chao ^b   Ma, Yuan Fang ^b   Zhao, Jin ^b   Wang, Chao Jie ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b HENAN UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; Caspase; Cell cycle; Mitochondrial membrane potential; Polyamine

Indexed keywords

ANTHRACENYLMETHYL HOMOSPERMIDINE; ANTINEOPLASTIC AGENT; CASPASE 3; POLYAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BEL 7402 CELL LINE; CANCER CELL CULTURE; CELL CYCLE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HEPATOMA CELL; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTHRACENES; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PROTO-ONCOGENE PROTEINS C-BCL-2; SPERMIDINE; TIME FACTORS;

EID: 35648992556     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00639.x     Document Type: Article

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