A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema

Journal of Allergy and Clinical Immunology

Volumn 120, Issue 5, 2007, Pages 1097-1102

  Schulz, Florian ^a,b   Marenholz, Ingo ^a,b   Fölster Holst, Regina ^c   Chen, Christiane ^a,b   Sternjak, Alexander ^b   Baumgrass, Ria ^d   Esparza Gordillo, Jorge ^a,b   Grüber, Christoph ^a   Nickel, Renate ^a   Schreiber, Stefan ^c   Stoll, Monika ^e   Kurek, Michael ^f   Rüschendorf, Franz ^b   Hubner, Norbert ^b   Wahn, Ulrich ^a   Lee, Young Ae ^a,b  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d German Rheumatism Research Center   (Germany)

^e Leibniz Institute for Arteriosclerosis Research   (Germany)

^f POMERANIAN MEDICAL UNIVERSITY   (Poland)

Author keywords

Eczema; gene expression; genetic association; haplotype; IL 31; nonatopic eczema; polymorphism; promoter; pruritus

Indexed keywords

CD3 ANTIBODY; CYTOKINE; INTERLEUKIN 31; MESSENGER RNA; MONOCLONAL ANTIBODY CD28; UNCLASSIFIED DRUG;

ARTICLE; ATOPIC DERMATITIS; CHILD; CHROMOSOME 12Q; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HAPLOTYPE; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE;

ADULT; CHILD; ECZEMA; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; INFANT; INTERLEUKINS; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 35648990052     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2007.07.065     Document Type: Article

References (18)

1. Leung D.Y., Boguniewicz M., Howell M.D., Nomura I., and Hamid Q.A. New insights into atopic dermatitis. J Clin Invest 113 (2004) 651-657
2. Williams H.C. Clinical practice. Atopic dermatitis. N Engl J Med 352 (2005) 2314-2324
3. Yosipovitch G., Greaves M.W., and Schmelz M. Itch. Lancet 361 (2003) 690-694
4. Küster W., Petersen M., Christophers E., Goos M., and Sterry W. A family study of atopic dermatitis. Clinical and genetic characteristics of 188 patients and 2,151 family members. Arch Dermatol Res 282 (1990) 98-102
5. Larsen F.S., Holm N.V., and Henningsen K. Atopic dermatitis. A genetic-epidemiologic study in a population-based twin sample. J Am Acad Dermatol 15 (1986) 487-494
6. Dillon S.R., Sprecher C., Hammond A., Bilsborough J., Rosenfeld-Franklin M., Presnell S.R., et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 5 (2004) 752-760
7. Bilsborough J., Leung D.Y., Maurer M., Howell M., Boguniewicz M., Yao L., et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 117 (2006) 418-425
8. Sonkoly E., Muller A., Lauerma A.I., Pivarcsi A., Soto H., Kemeny L., et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 117 (2006) 411-417
9. Warner J.O. A double-blinded, randomized, placebo-controlled trial of cetirizine in preventing the onset of asthma in children with atopic dermatitis: 18 months' treatment and 18 months' posttreatment follow-up. J Allergy Clin Immunol 108 (2001) 929-937
10. Hanifin J.M., and Rajka G. Diagnostic features of atopic dermatitis. Acta Derm (Stockholm) 92 suppl (1980) 44-47
11. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
12. Spielman R.S., and Ewens W.J. The TDT and other family-based tests for linkage disequilibrium and association. Am J Hum Genet 59 (1996) 983-989
13. Kruglyak L., Daly M.J., Reeve-Daly M.P., and Lander E.S. Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58 (1996) 1347-1363
14. Tan B.B., Weald D., Strickland I., and Friedmann P.S. Double-blind controlled trial of effect of housedust-mite allergen avoidance on atopic dermatitis. Lancet 347 (1996) 15-18
15. Wuthrich B., and Schmid-Grendelmeier P. The atopic eczema/dermatitis syndrome. Epidemiology, natural course, and immunology of the IgE-associated ("extrinsic") and the nonallergic ("intrinsic") AEDS. J Investig Allergol Clin Immunol 13 (2003) 1-5
16. Murphy K.M., and Reiner S.L. The lineage decisions of helper T cells. Nat Rev Immunol 2 (2002) 933-944
17. Schwenger G.T., Mordvinov V.A., and Sanderson C.J. Transcription factor GATA-3 is involved in repression of promoter activity of the human interleukin-4 gene. Biochemistry (Mosc) 70 (2005) 1065-1069
18. Schwenger G.T., Fournier R., Kok C.C., Mordvinov V.A., Yeoman D., and Sanderson C.J. GATA-3 has dual regulatory functions in human interleukin-5 transcription. J Biol Chem 276 (2001) 48502-48509