PTHrP-independent hypercalcemia with increased proinflammatory cytokines and bone resorption in two children with CD19-negative precursor B acute lymphoblastic leukemia

Pediatric Blood and Cancer

Volumn 49, Issue 7, 2007, Pages 990-993

  Niizuma, Hidetaka ^a   Fujii, Kunihiro ^a   Sato, Atsushi ^b   Fujiwara, Ikuma ^a   Takeyama, Junji ^b   Imaizumi, Masue ^b  

^a TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b MIYAGI CHILDREN S HOSPITAL   (Japan)

Author keywords

Bone resorption; CD19; Hypercalcemia; IL 6; Precursor B ALL; TNF

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; CALCITRIOL; CALCIUM; CD19 ANTIGEN; CD34 ANTIGEN; COLECALCIFEROL; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; DEOXYPYRIDINOLINE; HLA DR ANTIGEN; INTERLEUKIN 6; PARATHYROID HORMONE RELATED PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; B CELL LEUKEMIA; BONE BIOPSY; CALCIUM BLOOD LEVEL; CANCER CHEMOTHERAPY; CASE REPORT; CLINICAL FEATURE; HUMAN; HYPERCALCEMIA; IMMUNOPHENOTYPING; LEG PAIN; LETHARGY; MALE; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PATHOGENESIS; PRESCHOOL CHILD; PRIORITY JOURNAL; SYMPTOM; URINALYSIS;

AMINO ACIDS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CHILD, PRESCHOOL; CYTOKINES; DIPHOSPHONATES; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERCALCEMIA; IMMUNOPHENOTYPING; MALE; PARATHYROID HORMONE-RELATED PROTEIN; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; REMISSION INDUCTION; TREATMENT OUTCOME;

EID: 35648982295     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.20782     Document Type: Article

References (28)

1. McKay C, Furman WL. Hypercalcemia complicating childhood malignancies. Cancer 1993;72:256-260.
2. Wysolmerski JJ, Broadus AE. Hypercalcemia of malignancy: The central role of parathyroid hormone-related protein. Annu Rev Med 1994;45:189-200.
3. Hibi S, Funaki H, Ochiai-Kanai R, et al. Hypercalcemia in children presenting with acute lymphoblastic leukemia. Int J Hematol 1997;66:353-357.
4. Soni PN. Hypercalcaemia and multiple osteolytic lesions in childhood acute lymphoblastic leukaemia. Postgrad Med J 1993;69:483-485.
5. Callander NS, Roodman GD. Myeloma bone disease. Semin Hematol 2001;38:276-285.
6. Nosaka K, Miyamoto T, Sakai T, et al. Mechanism of hypercalcemia in adult T-cell leukemia: Overexpression of receptor activator of nuclear factor kappaB ligand on adult T-cell leukemia cells. Blood 2002;99:634-640.
7. Roodman GD. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 1997;80:1557-1563.
8. Hofbauer LC, Neubauer A, Heufelder AE. Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: Potential implications for the pathogenesis and treatment of malignant bone diseases. Cancer 2001;92:460-470.
9. Kudo O, Fujikawa Y, Itonaga I, et al. Proinflammatory cytokine (TNFalpha/IL-1 alpha) induction of human osteoclast formation. J Pathol 2002;198:220-227.
10. Rodan GA. Mechanisms of action of bisphosphonates. Annu Rev Pharmacol Toxicol 1998;38:375-388.
11. Berenson JR. Treatment of hypercalcemia of malignancy with bisphosphonates. Semin Oncol 2002;29:12-18.
12. Yoneda T, Michigami T, Yi B, et al. Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma. Cancer 2000;88:2979-2988.
13. Mikkola I, Heavey B, Horcher M, et al. Reversion of B cell commitment upon loss of Pax5 expression. Science 2002;297:110-113.
14. Mahmoud MS, Fujii R, Ishikawa H, et al. Enforced CD19 expression leads to growth inhibition and reduced tumorigenicity. Blood 1999;94:3551-3558.
15. Fujiwara I, Ogawa E, Kondo Y, et al. Hypophosphatemia in juvenile patients with systemic lupus erythematosus. Pediatr Int 2003;45:23-30.
16. Minamishima I, Ohga S, Ishii E, et al. Serum interleukin-6 and fever at diagnosis in children with acute leukemia. Am J Pediatr Hematol Oncol 1993;15:239-244.
17. Abrahamsson J, Pahlman M, Mellander L. Interekeukin 6, but not tumor necrosis factor-α, is a good predictor of severe infection in febrile neutropenic and non-neutropenia children with malignancy. Acta Paediatr 1997;86:1059-1064.
18. Abrahamsson J, Carlsson B, Mellander L. Tumor necrosis factor-α in malignant disease. Am J Pediatr Hematol Oncol 1993;15:364-369.
19. Pituch-Noworolska A, Wieckiewicz J, Gawlicka M, et al. The IL-6 gene expression by leukemic cells from acute lymphoblastic leukemia common and T type and modulation of IL-6 production by TNF. Hematologica 1998;29:101-114.
20. Schneider T, Seydlitz F, Zimmermann U, et al. Life threatening hypercalcemia in a young man with ALL. Dtsch Med Wochenschr 2001;126:7-11.
21. Fukasawa H, Kato A, Fujigaki Y, et al. Hypercalcemia in a patient with B-cell acute lymphoblastic leukemia: A role of proinflammatory cytokine. Am J Med Sci 2001;322:109-112.
22. Johnson RA, Boyce BF, Mundy GR, et al. Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice. Endocrinology 1989;124:1424-1427.
23. Barille S, Bataille R, Amiot M. The role of interleukin-6 and interleukin-6/interleukin-6 receptor-alpha complex in the pathogenesis of multiple myeloma. Eur Cytokine Netw 2000;11:546-551.
24. Abildgaard N, Glerup H, Rungby J, et al. Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma. Eur J Haematol 2000;64:121-129.
25. Yoneda T, Williams PJ, Niewolna M, et al. A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro. J Bone Miner Res 2001;16:1486-1495.
26. Pearse RN, Sordillo EM, Yaccoby S, et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001;98:11581-11586.
27. Ishikawa H, Tsuyama N, Mahmoud MS, et al. CD19 expression and growth inhibition of tumours in human multiple myeloma. Leuk Lymphoma 2002;43:613-616.
28. Sultan I, Kraveka JM, Lazarchick J. CD19 negative precursor B acute lymphoblastic leukemia presenting with hypercalcemia. Pediatr Blood Cancer 2004;43:66-69.