Hypercaicemia in a patient with B-cell acute lymphoblastic leukemia: A role of proinflammatory cytokine

American Journal of the Medical Sciences

Volumn 322, Issue 2, 2001, Pages 109-112

  Fukasawa, Hirotaka ^a   Kato, Akihiko ^a   Fujigaki, Yoshihide ^c   Yonemura, Katsuhiko ^a   Furuya, Ryuichi ^b   Hishida, Akira ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Iwata City Hospital   (Japan)

^c NONE

Author keywords

Acute lymphoblastic leukemia; Hypercalcemia; Interleukin 6; Soluble interleukin 2 receptor; Tumor necrosis factor

Indexed keywords

ANTINEOPLASTIC AGENT; CALCITRIOL; CALCIUM; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; PARATHYROID HORMONE; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; PARATHYROID HORMONE RELATED PROTEIN; PROTEIN; PTHLH PROTEIN, HUMAN; TUMOR MARKER; TUMOR PROTEIN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ARTICLE; BONE RADIOGRAPHY; CANCER CHEMOTHERAPY; CASE REPORT; CYTOKINE PRODUCTION; FEMALE; HORMONE BLOOD LEVEL; HUMAN; HYPERCALCEMIA; OSTEOLYSIS; PATHOGENESIS; B CELL LEUKEMIA; BLOOD; BONE MARROW; BONE TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; RADIOGRAPHY; SCINTISCANNING; SKULL TUMOR;

BONE MARROW; BONE NEOPLASMS; CALCITRIOL; CYTOKINES; FEMALE; HUMANS; HYPERCALCEMIA; INTERLEUKIN-6; LEUKEMIA, B-CELL, ACUTE; MIDDLE AGED; NEOPLASM PROTEINS; PARATHYROID HORMONE; PARATHYROID HORMONE-RELATED PROTEIN; PROTEINS; RECEPTORS, INTERLEUKIN-2; SKULL NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034742154     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000441-200108000-00009     Document Type: Article

References (22)

1. A parathyroid hormone-related protein implicated in malignant hypercalcemia. Cloning and expression
2. Parathyroid hormone-related protein in adult T-cell leukemia-lymphoma
3. Increased serum levels of a parathyroid hormone-like protein in malignancy-associated hypercalcemia
4. Serum calcium and phosphorus abnormalities in leukemia
5. Hypercalcemia in children presenting with acute lymphoblastic leukemia
6. A case of acute lymphoblastic leukemia accompanied with the production of parathyroid hormone-related protein
7. Common acute lymphoblastic leukemia preceded by hypercalcemia in an infant
8. Production of parathyroid hormone-related peptide in a patient with acute lymphocytic leukemia with extensive osteolytic lesions and hypercalcemia
9. Utility of measuring serum parathyroid hormone-related protein concentration in leukemic patients with hypercalcemia for assessing disease status
10. Response-oriented individualized induction therapy with six drugs followed by four courses of intensive consolidation, 1 year maintenance and intensification therapy: The ALL90 study of the Japan Adult Leukemia Study Group
11. Changes of the bones in the leukemias
12. Characteristics of acute lymphoblastic leukemia in children with osteopenia and vertebral compression fractures
13. Tumors producing human tumor necrosis factor induced hypercalcemia and osteoclastic bone resorption in nude mice
14. Increased production of tumor necrosis factor by normal immune cells in a model of the humoral hypercalcemia of malignancy
15. Evidence that tumor necrosis factor play a pathogenic role in the paraneoplastic syndromes of cachexia, hypercalcemia, and leukocytosis in a human tumor in nude mice
16. Interleukin -6 messenger RNA expression and interleukin-6 protein secretion in cells isolated from normal human bone
17. IL-6 is produced by osteoblasts and induces bone resorption
18. Functional, biochemical, and histopathologic consequences of high-dose interleukin-2 administration in rats
19. Hypercalcemia in B cell chronic lymphocytic leukaemia
20. Severe hypercalcemia and extensive osteolytic lesions in an adult patient with T cell acute lymphoblastic leukaemia
21. Severe hypercalcemia in B-cell lymphoma combined effects of PTH-rP, IL-6, TNF-α
22. A novel mature B-cell line (DOBIL-6) producing both parathyroid hormone-related protein and interleukin-6 from a myeloma patient presenting with hypercalcemia