Cutting and stitching: The cross-linking of peptidoglycan in the assembly of the bacterial cell wall

ACS Chemical Biology

Volumn 2, Issue 9, 2007, Pages 602-605

  Buynak, John D ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CARBOXYPEPTIDASE; GAMMA GLUTAMYLTRANSFERASE; PENICILLIN BINDING PROTEIN; PENICILLIN G; PEPTIDOGLYCAN; POLYPEPTIDE ANTIBIOTIC AGENT;

ANTIBIOTIC RESISTANCE; BACTERIAL CELL WALL; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN CROSS LINKING; PROTEIN FUNCTION; REVIEW; STAPHYLOCOCCUS AUREUS; STRUCTURE ANALYSIS; SYNTHESIS;

BACTERIA; BACTERIAL PROTEINS; CELL WALL; PENICILLIN-BINDING PROTEINS; PENICILLINS; PEPTIDOGLYCAN;

BACTERIA (MICROORGANISMS);

EID: 35648977045     PISSN: 15548929     EISSN: None     Source Type: Journal    
DOI: 10.1021/cb700182u     Document Type: Review

References (18)

1. Gordon, E., Mouz, N., Duee, E., and Dideberg, O. (2000) The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implications in drug resistance, J. Mol. Biol. 299, 477-485.
2. Lim, D., and Strynadka, N. C. J. (2002) Structural basis for the β-lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus, Nat. Struct Biol. 9, 870-876.
3. Rohrer, S., Ehlert K., Tschierske, M., Labischinski, H., and Sberger-Bachi, B. (1999) The essential Staphylococcus aureus gene fmhB is involved in the first step of peptidoglycan pentaglycine interpeptide formation, Proc. Natl. Acad. Sci. U.SA. 96, 9351-9356.
4. Tipper, D. I., and Strominger, J. L. (1965) Mechanism of action of penicillins: a proposal based on their structural similarity to aCyl-D-alanyl-D-alanine, Proc Natl. Acad. Sci. U.SA. 54, 1133-1141.
5. Yuan, Y., Barrett D., Zhang, Y., Kahne, D., Sliz, P., and Walker, S. (2007) Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis, Proc. Natl. Acad Sci. U.SA. 104, 5348-5353.
6. Lovering, A. L., de Castro, L. H., Lim, D., and Strynadka, N. C. J. (2007) Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis, Science 315, 1402-1405.
7. Amanuma, H., and Strominger, J. L. (1980) Purification and properties of penicillin-binding proteins 5 and 6 from Escherichia coli membranes, J. Biol. Chem. 255, 11173-11180.
8. Zdzislaw, M., Broome-Smith, J. K., Schwarz, U., and Spraft, B. G. (1982) Spherical E. coli due to elevated levels Of D-alanine carboxypeptidase, Nature 297, 702-704.
9. Pollock, J. J., Ghuysen, J. M., Linder, R., Salton, M. R. J., Perkins, H. R., Nieto, M., Leyh-Bouille, M., Frere, J. M., and Johnson, K. (1972) Transpeptidase activity of Streptomyceso-alanyl-D-carboxy-peptidases, Proc. Natl. Acad. Sci. U.S.A. 69, 662-666.
10. Kelly, J. A., and Kuzin, A. P. (1995) The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution, J. Mol. Biol. 254, 223-236.
11. Hakenbeck, R., Konig, A., Kern, I., van der Linden, M., Keck, W., Billot-Klein, D., Legrand, R., Schoot, B., and Gutmann, L. (1998) Acquisition of five high-Mr penicillin-binding protein variants during transfer of high-level β-lactam resistance from Streptococcus mitis to Streptococcus pneumoniae, J. Bacteriol. 180, 1831-1840.
12. Anderson, J. W., Adediran, S. A., Charlier, P., Nguyen-Disteche, M., Frere, J.-M., Nicholas, R. A., and Pratt, R. F. (2003) On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides, Biochem. J. 373, 949-955.
13. Kumar, I., and Pratt, R. F. (2005) Transpeptidation reactions of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: the structural basis of acyl acceptor specificity, Biochemistry 44, 9961-9970.
14. Kumar, I., and Pratt, R. F. (2005) Transpeptidation reactions of a specific substrate catalyzed by the Streptomyces R61 DD-peptidase: characterization of a chromogenic substrate and acyl acceptor design, Biochemistry 44, 9971-9979.
15. Josephine, H. R., Charlier, P., Davies, C., Nicholas, R. A., and Pratt, R. F. (2006) Reactivity of penicillin-binding proteins with peptidoglycan-mimetic β-lactams: what's wrong with these enzymes? Biochemistry 45, 15873-15883.
16. Macheboeuf, P., Di Guilmi, A. M., Job, V., Vernet, T., Dideberg, O., and Dessen, A. (2005) Active site restructuring regulates ligand recognition in class A penicillin-binding proteins, Proc Natl. Acad. Sci. U.S.A. 102, 577-582.
17. Lovering, A. L., De Castro, L., Lim, D., and Strynadka, N. C. J. (2007) Structural analysis of an "open" form of PBP1B from Stroptococcus pneumoniae, Protein Sci. 15, 1701-1709.
18. Born, P., Breukink, E., and Vollmer, W. (2006) In vitro synthesis of cross-linked murein and its attachment to sacculi by PBP1A from Escherichia coli, J. Biol. Chem. 281, 26985-26993.