Enhanced effects of guggulsterone plus 1,25(OH)2D3 on 3T3-L1 adipocytes

Biochemical and Biophysical Research Communications

Volumn 364, Issue 3, 2007, Pages 450-456

  Rayalam, Srujana ^a   Della Fera, Mary Anne ^a   Ambati, Suresh ^a   Boyan, Barbara ^c   Baile, Clifton A ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Adipocyte specific transcription factors; Adipocytes; Adipogenesis; aP2; Apoptosis; Farnesoid X receptor; Guggul; Vitamin D; Vitamin D receptor

Indexed keywords

CALCITRIOL; FARNESOID X RECEPTOR; GUGGULSTERONE; VITAMIN D RECEPTOR;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL STRAIN 3T3; CONTROLLED STUDY; EMBRYO; LIPID STORAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; MICE; PREGNENEDIONES; VITAMIN D;

EID: 35648974175     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.10.051     Document Type: Article

References (27)

1. Somjen D., Kaye A.M., Harell A., and Weisman Y. Modulation by vitamin D status of the responsiveness of rat bone to gonadal steroids. Endocrinology 125 (1989) 1870-1876
2. Zhou Y.S., Liu Y.S., and Tan J.G. Is 1, 25-dihydroxyvitamin D3 an ideal substitute for dexamethasone for inducing osteogenic differentiation of human adipose tissue-derived stromal cells in vitro?. Chin. Med. J. (Engl) 119 (2006) 1278-1286
3. Kong J., and Li Y.C. Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. Am. J. Physiol. Endocrinol. Metab. 290 (2006) E916-E924
4. Sun X., and Zemel M.B. Role of uncoupling protein 2 (UCP2) expression and 1alpha, 25-dihydroxyvitamin D3 in modulating adipocyte apoptosis. FASEB J. 18 (2004) 1430-1432
5. Hedlund T.E., Moffatt K.A., and Miller G.J. Stable expression of the nuclear vitamin D receptor in the human prostatic carcinoma cell line JCA-1: evidence that the antiproliferative effects of 1 alpha, 25-dihydroxyvitamin D3 are mediated exclusively through the genomic signaling pathway. Endocrinology 137 (1996) 1554-1561
6. Blumberg J.M., Tzameli I., Astapova I., Lam F.S., Flier J.S., and Hollenberg A.N. Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. J. Biol. Chem. 281 (2006) 11205-11213
7. Drent M.L., and van der Veen E.A. Endocrine aspects of obesity. Neth. J. Med. 47 (1995) 127-136
8. Scragg R., Holdaway I., Singh V., Metcalf P., Baker J., and Dryson E. Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus. Diabetes Res. Clin. Pract. 27 (1995) 181-188
9. Shishodia S., and Aggarwal B.B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J. Biol. Chem. 279 (2004) 47148-47158
10. Satyavati G.V. Gum guggul (Commiphora mukul)-the success story of an ancient insight leading to a modern discovery. Indian J. Med. Res. 87 (1988) 327-335
11. Urizar N.L., and Moore D.D. GUGULIPID: a natural cholesterol-lowering agent. Annu. Rev. Nutr. 23 (2003) 303-313
12. Rizzo G., Disante M., Mencarelli A., Renga B., Gioiello A., Pellicciari R., and Fiorucci S. The farnesoid x receptor promotes adipocyte differentiation and regulates adipose cell function in vivo. Mol. Pharmacol. 70 (2006) 1164-1173
13. Honjo Y., Sasaki S., Kobayashi Y., Misawa H., and Nakamura H. 1,25-dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor. J. Endocrinol. 188 (2006) 635-643
14. Hemati N., Ross S.E., Erickson R.L., Groblewski G.E., and MacDougald O.A. Signaling pathways through which insulin regulates CCAAT/enhancer binding protein alpha (C/EBPalpha) phosphorylation and gene expression in 3T3-L1 adipocytes. Correlation with GLUT4 gene expression. J. Biol. Chem. 272 (1997) 25913-25919
15. Suryawan A., and Hu C.Y. Effect of serum on differentiation of porcine adipose stromal-vascular cells in primary culture. Comp. Biochem. Physiol. Comp. Physiol. 105 (1993) 485-492
16. Frankfurt O.S. Immunoassay for single-stranded DNA in apoptotic cells. Methods Mol. Biol. 282 (2004) 85-101
17. Yang J.Y., Della-Fera M.A., Nelson-Dooley C., and Baile C.A. Molecular mechanisms of apoptosis induced by ajoene in 3T3-L1 adipocytes. Obesity (Silver Spring) 14 (2006) 388-397
18. Samudio I., Konopleva M., Safe S., McQueen T., and Andreeff M. Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Mol. Cancer Ther. 4 (2005) 1982-1992
19. Hida Y., Kawada T., Kayahashi S., Ishihara T., and Fushiki T. Counteraction of retinoic acid and 1,25-dihydroxyvitamin D3 on up-regulation of adipocyte differentiation with PPAR gamma ligand, an antidiabetic thiazolidinedione, in 3T3-L1 cells. Life Sci. 62 (1998) Pl205-Pl211
20. Burris T.P., Montrose C., Houck K.A., Osborne H.E., Bocchinfuso W.P., Yaden B.C., Cheng C.C., Zink R.W., Barr R.J., Hepler C.D., Krishnan V., Bullock H.A., Burris L.L., Galvin R.J., Bramlett K., and Stayrook K.R. The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. Mol. Pharmacol. 67 (2005) 948-954
21. Gregoire F.M., Smas C.M., and Sul H.S. Understanding adipocyte differentiation. Physiol. Rev. 78 (1998) 783-809
22. J.Y. Yang, M.A. Della-Fera, C.A. Baile, Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells, Obesity (Silver Spring), in press, doi:10.1038/oby.2007.24.
23. Singh S.V., Zeng Y., Xiao D., Vogel V.G., Nelson J.B., Dhir R., and Tripathi Y.B. Caspase-dependent apoptosis induction by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol. Cancer Ther. 4 (2005) 1747-1754
24. Makishima M., Okamoto A.Y., Repa J.J., Tu H., Learned R.M., Luk A., Hull M.V., Lustig K.D., Mangelsdorf D.J., and Shan B. Identification of a nuclear receptor for bile acids. Science 284 (1999) 1362-1365
25. Urizar N.L., Liverman A.B., Dodds D.T., Silva F.V., Ordentlich P., Yan Y., Gonzalez F.J., Heyman R.A., Mangelsdorf D.J., and Moore D.D. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science 296 (2002) 1703-1706
26. De Gottardi A., Dumonceau J.M., Bruttin F., Vonlaufen A., Morard I., Spahr L., Rubbia-Brandt L., Frossard J.L., Dinjens W.N., Rabinovitch P.S., and Hadengue A. Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro. Mol. Cancer 5 (2006) 48
27. J.M. Pascussi, S. Gerbal-Chaloin, C. Duret, M. Daujat-Chavanieu, M.J. Vilarem, P. Maurel, The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences, Annu. Rev. Pharmacol. Toxicol. 48 (2008) in press, doi:10.1146/annurev.pharmtox.47.120505.105349.