A proximal direct repeat motif characterized as a negative regulatory element in the human renin gene

Journal of Cellular Biochemistry

Volumn 102, Issue 4, 2007, Pages 1043-1050

  Konoshita, Tadashi ^a   Fuchs, Sébastien ^b   Makino, Yasukazu ^a   Wakahara, Shigeyuki ^a   Miyamori, Isamu ^a  

^a University of Fukui   (Japan)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ARP 1; cis element; COUP TFII; NR2F2; Renin; Renin angiotensin system; trans factor

Indexed keywords

DEOXYRIBONUCLEASE I; DNA; RENIN;

ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; DNA FOOTPRINTING; DNA PROTEIN COMPLEX; GEL MOBILITY SHIFT ASSAY; GENE CONSTRUCT; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; HUMAN; HUMAN CELL; KIDNEY CORTEX; PRIORITY JOURNAL; REGULATORY DNA SEQUENCE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TRANSCRIPTION REGULATION; WILD TYPE;

AMINO ACID MOTIFS; BASE SEQUENCE; BINDING SITES; COUP TRANSCRIPTION FACTOR II; GENE EXPRESSION REGULATION; HUMANS; MUTATION; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REGULATORY ELEMENTS, TRANSCRIPTIONAL; RENIN; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 35648960872     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21341     Document Type: Article

References (36)

1. Borensztein P, Germain S, Fuchs S, Philippe J, Corvol P, Pinet F. 1994. Cis-regulatory elements and trans-acting factors directing basal and cAMP-stimulated human renin gene expression in chorionic cells. Circ Res 74: 764-773.
2. Burt DW, Nakamura N, Kelley P, Dzau VJ. 1989. Identification of negative and positive regulatory elements in the human renin gene. J Biol Chem 264:7357-7362.
3. Corvol P, Soubrier F, Jeunemaitre X. 1997. Molecular genetics of the renin-angiotensin-aldosterone system in human hypertension. Pathol Biol (Paris) 45:229-239.
4. Danilczyk U, Penninger JM. 2006. Angiotensin-converting enzyme II in the heart and the kidney. Circ Res 98:463-471.
5. Dzau V. 2005. The cardiovascular continuum and renin-angiotensin- aldosterone system blockade. J Hypertens Suppl 23:S9-17.
6. Fuchs S, Germain S, Philippe J, Corvol P, Pinet F. 2002. Expression of renin in large arteries outside the kidney revealed by human renin promoter/LacZ transgenic mouse. Am J Pathol 161:717-725.
7. Fuchs S, Philippe J, Corvol P, Pinet F. 2003. Implication of Ref-1 in the repression of renin gene transcription by intracellular calcium. J Hypertens 21:327-335.
8. Germain S, Konoshita T, Philippe J, Corvol P, Pinet F. 1996. Transcriptional induction of the human renin gene by cyclic AMP requires cyclic AMP response element-binding protein (CREB) and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif. Biochem J 316:107-113.
9. Germain S, Bonnet F, Philippe J, Fuchs S, Corvol P, Pinet F. 1998. A novel distal enhancer confers chorionic expression on the human renin gene. J Biol Chem 273: 25292-25300.
10. Giguere V. 1999. Orphan nuclear receptors: From gene to function. Endocr Rev 20:689-725.
11. Konoshita T, Germain S, Philippe J, Corvol P, Pinet F. 1996. Evidence that renal and chorionic tissues contain similar nuclear binding proteins that recognize the human renin promoter. Kidney Int 50:1515-1524.
12. Konoshita T, Makino Y, Wakahara S, Ido K, Yoshida M, Kawai Y, Miyamori I. 2004. Candidate cis-elements for human renin gene expression in the promoter region. J Cell Biochem 93:327-336.
13. Konoshita T, Wakahara S, Mizuno S, Motomura M, Aoyama C, Makino Y, Kawai Y, Kato N, Koni I, Miyamori I, Mabuchi H. 2006. Tissue gene expression of renin-angiotensin system in human type 2 diabetic nephropathy. Diabetes Care 29:848-852.
14. Ladias JA, Karathanasis SK. 1991. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251:561-565.
15. Lang JA, Yang G, Kern JA, Sigmund CD. 1995. Endogenous human renin expression and promoter activity in CALU-6, a pulmonary carcinoma cell line. Hypertension 25:704-710.
16. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP. 2002. 1,25- Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 110:229-238.
17. Liu X, Huang X, Sigmund CD. 2003. Identification of a nuclear orphan receptor (Ear2) as a negative regulator of renin gene transcription. Circ Res 92:1033-1040.
18. Montminy MR, Sevarino KA, Wagner JA, Mandel G, Goodman RH. 1986. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc Natl Acad Sci USA 83:6682-6686.
19. Nguyen G. 2006. Renin/prorenin receptors. Kidney Int 69:1503-1506.
20. Pan L, Xie Y, Black TA, Jones CA, Pruitt SC, Gross KW. 2001. An Abd-B class HOX.PBX recognition sequence is required for expression from the mouse Ren-1c gene. J Biol Chem 276:32489-32494.
21. Pereira FA, Qiu Y, Tsai MJ, Tsai SY. 1995. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): expression during mouse embryogenesis. J Steroid Biochem Mol Biol 53:503-508.
22. Pereira FA, Qiu Y, Zhou G, Tsai MJ, Tsai SY. 1999. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev 13: 1037-1049.
23. Pereira FA, Tsai MJ, Tsai SY. 2000. COUP-TF orphan nuclear receptors in development and differentiation. Cell Mol Life Sci 57:1388-1398.
24. Petrovic N, Black TA, Fabian JR, Kane C, Jones CA, Loudon JA, Abonia JP, Sigmund CD, Gross KW. 1996. Role of proximal promoter elements in regulation of renin gene transcription. J Biol Chem 271:22499-22505.
25. Pinet F, Corvol MT, Bourguignon J, Corvol P. 1988. Isolation and characterization of renin-producing human chorionic cells in culture. J Clin Endocrinol Metab 67: 1211-1220.
26. Remuzzi G, Perico N, Macia M, Ruggenenti P. 2005. The role of renin-angiotensin-aldosterone system in the progression of chronic kidney disease. Kidney Int Suppl S57-65.
27. Shi Q, Gross KW, Sigmund CD. 2001. Retinoic acid-mediated activation of the mouse renin enhancer. J Biol Chem 276:3597-3603.
28. Shibata H, Ikeda Y, Mukai T, Morohashi K, Kurihara I, Ando T, Suzuki T, Kobayashi S, Murai M, Saito I, Saruta T. 2001. Expression profiles of COUP-TF, DAX-1, and SF-1 in the human adrenal gland and adrenocortical tumors: Possible implications in steroidogenesis. Mol Genet Metab 74:206-216.
29. Sigmund CD, Okuyama K, Ingelfinger J, Jones CA, Mullins JJ, Kane C, Kim U, Wu CZ, Kenny L, Rustum Y, Dzau VJ, Gross KW. 1990. Isolation and characterization of renin-expressing cell lines from transgenic mice containing a renin-promoter viral oncogene fusion construct. J Biol Chem 265:19916-19922.
30. Smith DL, Morris BJ, Do YS, Law RE, Shaw KJ, Hseuh WA. 1994. Identification of cyclic AMP response element in the human renin gene. Biochem Biophys Res Commun 200:320-329.
31. Suzuki T, Takahashi K, Darnel AD, Moriya T, Murakami O, Narasaka T, Takeyama J, Sasano H. 2000. Chicken ovalbumin upstream promoter transcription factor II in the human adrenal cortex and its disorders. J Clin Endocrinol Metab 85:2752-2757.
32. Tamura K, Umemura S, Ishii M, Tanimoto K, Murakami K, Fukamizu A. 1994. Molecular mechanism of transcriptional activation of angiotensinogen gene by proximal promoter. J Clin Invest 93:1370-1379.
33. Tamura K, Chen YE, Horiuchi M, Chen Q, Daviet L, Yang Z, Lopez-Ilasaca M, Mu H, Pratt RE, Dzau VJ. 2000. LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. Proc Natl Acad Sci USA 97:8513-8518.
34. Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. 1989. COUP transcription factor is a member of the steroid receptor superfamily. Nature 340: 163-166.
35. Wang LH, Ing NH, Tsai SY, O'Malley BW, Tsai MJ. 1991. The COUP-TFs compose a family of functionally related transcription factors. Gene Expr 1:207-216.
36. Wasylyk B, Hahn SL, Giovane A. 1993. The Ets family of transcription factors. Eur J Biochem 211:7-18.