Expression of epidermal growth factor receptor protein in the liver of db/db mice after partial hepatectomy

Experimental and Toxicologic Pathology

Volumn 59, Issue 3-4, 2007, Pages 157-162

  Shirai, Makoto ^a   Yamauchi, Hirofumi ^a   Nakayama, Hiroyuki ^a   Doi, Kunio ^a   Uetsuka, Koji ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

db db mice; EGFR; Fatty change; Liver regeneration; Partial hepatectomy

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; RECEPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER REGENERATION; MOUSE; NONHUMAN; PARTIAL HEPATECTOMY; PROTEIN EXPRESSION; WESTERN BLOTTING;

MUS;

EID: 35648956644     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etp.2007.06.003     Document Type: Article

References (16)

1. Considine R.V., and Caro J.F. Leptin and the regulation of body weight. Int J Biochem Cell Biol 29 (1997) 1255-1272
2. Higgins G.M., and Anderson R.M. Restoration of the liver of the white rat following partial surgical removal. Arch Pathol 12 (1931) 186-202
3. Kaplan L.M. Leptin, obesity, and liver disease. Gastroenterol 115 (1998) 997-1001
4. Kasayama S., Yoshimura M., and Oka T. Decreased expression of hepatic epidermal growth factor receptor gene in diabetic mice. J Mol Endocrinol 3 (1989) 49-56
5. Lambotte L., Saliez A., Triest S., Maiter D., Baranski A., Barker A., et al. Effect of sialoadenectomy and epidermal growth factor administration on liver regeneration after partial hepatectomy. Hepatology 25 (1997) 607-612
6. Lev-Ran A., Hwang D.L., and Barseghian G. Decreased expression of liver epidermal growth factor receptors in rats with alloxan and streptozotocin diabetes. Biochem Biophys Res Commun 137 (1986) 258-262
7. Noguchi S., Ohba Y., and Oka T. Influence of epidermal growth factor on liver regeneration after partial hepatectomy in mice. J Endocrinol 128 (1991) 425-431
8. Picard C., Lambotte L., Starkel P., Sempoux C., Saliez A., Van den Berge V., et al. Steatosis is not sufficient to cause an impaired regenerative response after partial hepatectomy in rats. J Hepatol 36 (2002) 645-652
9. Rao M.S., and Reddy J.K. The effect of microvesicular fatty change on liver regeneration after partial hepatectomy. Hepatogastroenterology 47 (2000) 912-915
10. Redaelli C.A., Semela D., Carrick F.E., Ledermann M., Candinas D., Sauter B., et al. Effect of vascular endothelial growth factor on functional recovery after hepatectomy in lean and obese mice. J Hepatol 40 (2004) 305-312
11. Selzner M., and Clavien P.A. Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway. Hepatology 31 (2000) 35-42
12. Solinas G., Naugler W., Galimi F., Lee M.S., and Karin M. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proc Natl Acad Sci USA 103 (2006) 16454-16459
13. Wang T., Fontenot R.D., Soni M.G., Bucci T.J., and Mehendale H.M. Enhanced hepatotoxicity and toxic outcome of thioacetamide in streptozotocin-induced diabetic rats. Toxicol Appl Pharmacol 166 (2000) 92-100
14. Yamauchi H., Uetsuka K., Okada T., Nakayama H., and Doi K. Impaired liver regeneration after partial hepatectomy in db/db mice. Exp Toxicol Pathol 54 (2003) 281-286
15. Yang S.Q., Lin H.Z., Mandal A.K., Huang J., and Diehl A.M. Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. Hepatology 34 (2001) 694-706
16. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432