Behavioral effects of subchronic inorganic manganese exposure in rats

American Journal of Industrial Medicine

Volumn 50, Issue 11, 2007, Pages 841-852

  Vezer T ^a   Kurunczi, A ^b   Naray M ^c   Papp, A ^a   Nagymajtenyi L ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c Chemical Laboratory   (Hungary)

Author keywords

d amphetamine; Exploratory activity; GFAP; Manganese; Maze; Open field; Psychomotor performance; Rat; Sensorimotor gating; Spatial learning

Indexed keywords

AMPHETAMINE; MAGNESIUM; MAGNESIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN CORTEX; BRAIN TISSUE; CONTROLLED STUDY; DENTATE GYRUS; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG MEGADOSE; EXPLORATORY BEHAVIOR; GLIOSIS; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTOXICATION; LONG TERM EXPOSURE; MALE; MEMORY CONSOLIDATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; OCCUPATIONAL EXPOSURE; OPEN FIELD BEHAVIOR; PARKINSONISM; PHYSICAL ACTIVITY; PREPULSE INHIBITION; PSYCHOMOTOR DEVELOPMENT; PSYCHOMOTOR PERFORMANCE; RAT; SENSORIMOTOR CORTEX; SPATIAL MEMORY;

ADMINISTRATION, ORAL; ANIMALS; BEHAVIOR, ANIMAL; DENTATE GYRUS; DEXTROAMPHETAMINE; GAIT DISORDERS, NEUROLOGIC; GLIAL FIBRILLARY ACIDIC PROTEIN; HUNGARY; MALE; MANGANESE; MAZE LEARNING; PSYCHOMOTOR PERFORMANCE; RATS; RATS, WISTAR;

EID: 35648952654     PISSN: 02713586     EISSN: 10970274     Source Type: Journal    
DOI: 10.1002/ajim.20485     Document Type: Article

References (46)

1. Alexander GE, Crutcher MD, DeLong MR. 1990. Basal ganglia-thalamocortical circuits: Parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. Prog Brain Res 85:119-146.
2. Aschner M, Vrana KE, Zheng W. 1999. Manganese uptake and distribution in the central nervous system (CNS). NeuroToxicol 20: 173-180.
3. Beatty W, Shavalia DA. 1982. Spatial memory in rats: Time course of working memory and effect of anestetics. Behav Neural Biol 28:454-462.
4. Bouchard M, Mergler D, Baldwin M. 2005. Manganese exposure and age: Neurobehavioral performance among alloy production workers. Environ Toxicol Pharmacol 19:687-694.
5. Bowler RM, Koller W, Schulz PE. 2006. Parkinsonism due to manganism in a welder: Neurological and neuropsychological sequelae. NeuroToxicol 27:327-332.
6. Butterworth RF. 1998. Pathogenesis of acute hepatic encephalopathy. Digest 59:6-21.
7. Calabresi P, De Murtas M, Bernardi G. 1997. The neostriatum beyond the motor function: Experimental and clinical evidence. Neurosci 78:39-60.
8. Clarkson PB, Jakubovic A, Fibiger HC. 1988. Anatomical analysis of the involvement of mesolimbocortical dopamine in the locomotor stimulant actions of d-amphetamine and apomorphine. Psychopharmacol 96:511-520.
9. Couper J. 1837. On the effects of black oxide of manganese when inhaled into the lungs. Br Ann Med Pharmacol 1:41-42.
10. Crinella FM, Cordova EJ, Ericsson J. 1998. Manganese, aggression, and attention-deficit hyperactivity disorder. NeuroToxicol 19:468-469.
11. Desole MS, Miele M, Esposito G, Migheli R, Fresu L, Enrico P, De Natale G, Miele E. 1994. Monoaminergic system activity and cellular defense mechanisms in the brainstem of young and aged rats subchronically exposed to manganese. Neurosci Lett 177:71-74.
12. Dorman DC, Stuve MF, Vitarella D, Byerly L, Goetz J, Miller R. 2000. Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J Appl Toxicol 20:179-187.
13. Eyre MD, Richter-Levin G, Avital A, Stewart M. 2003. Morphological changes in hippocampal dentate gyrus synapses following spatial learning in rats are transient. Eur J Neurosci 17:1973-1980.
14. Ferraz HB, Bertolucci PH, Pereira JS, Lima JG, Andrade LA. 1988. Chronic exposure to the fungicide maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 38:550-553.
15. Fink JS, Smith GP. 1980. Relationships between selective denervation of dopamine terminal fields in the anterior forebrain and behavioral responses to amphetamine and apomorphine. Brain Res 20:107-127.
16. Gifkins A, Greba Q, Kokkinidis L. 2002. Ventral tegmental area DA neurons mediate the shock sensitization of acoustic startle: A potential site of action for benzodiazepin anxiolytics. Behav Neurosci 116:785-794.
17. Gorell JM, Johnson CC, Rybicki AB, Peterson EL, Korstha GX, Brown GG, Richardson RJ. 1979. Occupational exposures to metals as risk factors for Parkinson's disease. Neurology 48:650-658.
18. Graham F. 1975. The more-or-less startling effects of weak prestimuli. Psychophysiol 12:238-248.
19. Hirata Y, Kiuchi K, Nagatsu T. 2001. Manganese mimics the action of 1-methyl-phenylpyridinium ion, a dopaminergic neurotoxin, in rat striatal tissue slices. Neurosci Lett 311:53-56.
20. Koch M. 1999. The neurobiology of startle. Prog Neurobiol 59:107-128.
21. Kondakis XG, Makris N, Leotsinidis M, Papapetropoulos T. 1989. Possible health effects of high manganese concentration in drinking water. Arch Environ Health 44:175-178.
22. Lai JC, Leung TK, Lim L. 1981. Brain regional distribution of glutamic acid decarboxylase, choline acetyltransferase, and acetylcholinesterase in the rat: Effects of chronic manganese chloride administration after two years. J Neurochem 36:1443-1448.
23. Lee Y, Lopez DE, Meloni EG, Davis M. 1996. A primary acoustic startle pathway: Obligatory role of cochlear root neurons and the nucleus reticularis pontis caudalis. J Neurosci 16:3775-3789.
24. Lucchini R, Apostoli P, Perrone C, Placidi D, Albini E, Migliorati P. 1999. Long-term exposure to "low-levels" of manganese oxides and neurofunctional changes in ferroalloy workers. NeuroToxicol 20:287-297.
25. Lynam DR, Roos JW, Pfeifer GD, Fort BF, Pullin TG. 1999. Environmental effects and exposures to manganese from ue of methylcyclopentadienyl manganese tricarbonyl (MMT) in gasoline. NeuroToxicol 20:145-150.
26. Marlowe M, Bliss L. 1993. Hair element concentrations and young children's behavior at school and home. J Orthomol Med 9:1-12.
27. Mattsson A, Pernold K, Ögren SO, Olson L. 2004. Loss of cortical acetylcholine enhances amphetamine-induced locomotor activity. Neuroscience 127:579-591.
28. Mergler D. 1999. Neurotoxic effects of low level exposure to manganese in human populations. Environ Res Section A 80:99-102.
29. Mergler D, Huel G, Bowler R, Iregren A, Belanger S, Baldwin M, Tardif R, Smargiassi A, Martin L. 1994. Nervous system dysfunction among workers with long-term exposure to manganese. Environ Res 64:151-180.
30. Mertz W, Abernathy CO, Olin SS. 1994. Concluding remarks. In: Mertz W, Abernathy CO, Olin SS, editors. Risk assessment of essential elements. Washington, DC: ILSI Press. p 291-293.
31. Myers JE, Thompson ML, Ramushu S, Young T, Jeebhay MF, London L, Esswein E, Renton K, Spies A, Boulle A, Naik I, Iregren A, Rees DJ. 2003. The nervous system effects of occupational exposure on workers in a South African manganese smelter. NeuroToxicol 24:885-894.
32. Oberlander C, Demassey Y, Verdu A, van de Valde D, Bardeley C. 1987. Tolerance to the serotonin 5-HT1 agonist RU24969 and effects on dopaminergic behaviour. Eur J Pharmacol 139:205-214.
33. Pappas BA, Zhang D, Davidson CM, Crowder P, Park GA, Fortin T. 1997. Prenatal manganese exposure: Behavioral, neurochemical, an histopathological effects in rat. Neurotox Teratol 19:17-25.
34. Physical and Theoretical Chemistry Laboratory. 2001. Safety data for manganese (II) chloride tetrahydrate. http://physchem.ox.ac.uk/MSDS, Oxford, UK.
35. Ponzoni S, Guimaraes FS, Del Bel EA, Garcia-Cairasco N. 2000. Behavioral effects of intra-nigral microinjections of manganese chloride: Interaction with nitric oxide. Prog Neuro-Psychopharmacol Biol Psych 24:307-325.
36. 4 by rats: Tissue accumulation and distribution of manganese in two generations. J Toxicol Env Health 9:175-188.
37. Subhash MN, Padmashree TS. 1991. Effect of manganese on biogenic amine metabolism in regions of the rat brain. Food Chem Toxicol 29:579-582.
38. Swerdlow NR, Geyer MA, Braff DL. 2001. Neural circuit regulation of prepulse inhibition of startle in the rat: Current knowledge and future challenges. Psychopharmacol 156:194-215.
39. Takeda A, Sawashita J, Okada S. 1998. Manganese concentration in rat brain: Manganese transport from the peripheral tissues. Neurosci Lett 242:45-48.
40. Takser L, Mergler D, Hellier G, Sahuquillo J, Huel G. 2003. Manganese, monoamine metabolite levels at birth, and childhood psychomotor development. NeuroToxicol 24:667-674.
41. Trepper MJ, Paladini CA, Celada P. 1998. Gabaergic control of the firing pattern of substantia nigra dopaminergic neurons. Adv Pharmacol 42: 694-699.
42. Verity MA. 1999. Manganese neurotoxicity: A mechanistic hypothesis. NeuroToxicol 20:489-497.
43. Walsh TJ, Schulz DW, Tilson HA, Schmechel DE. 1986. Colchicine-induced granule cell loss in rat hippocampus: Selective behavioral and histological alterations. Brain Res 398:23-36.
44. Wennberg A, Iregren A, Struwe G, Cizinsky G, Hagman M, Johansson L. 1991. Manganese exposure in steel smelters a health hazard to the nervous system. Scand J Work Environ Health 17:255-262.
45. Wise RA. 1998. Drug-activation of brain reward pathways. Drug Alcohol Depend 51:13-22.
46. Yourdaydin C, Hörtnagl H, Steindl P, Zimmermann C, Pifl C, Singer EA, Roth E, Ferenci P. 1990. Increased serotoninergic and noradrenergic activity in hepatic encephalopathy in rats with thio-acetamide-induced acute liver failure. Hepatol 12:695-700.