Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence

Journal of Pharmaceutical and Biomedical Analysis

Volumn 45, Issue 4, 2007, Pages 659-666

  Xu, Hong Rong ^a   Li, Xue Ning ^a   Chen, Wei Li ^a   Chu, Nan Nan ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

3 Hydroxydesloratadine; Desloratadine; LC MS MS; Liquid liquid extraction

Indexed keywords

3 HYDROXYDESLORATADINE; ACETONITRILE; AMMONIUM FORMATE; DESLORATADINE; DRUG METABOLITE; ETHER; METHANOL; UNCLASSIFIED DRUG; WATER;

ARTICLE; BIOEQUIVALENCE; CALIBRATION; DEVICE; DRUG BLOOD LEVEL; DRUG DETERMINATION; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; PLASMA; POSITIVE ION ELECTROSPRAY; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ADMINISTRATION, ORAL; CHROMATOGRAPHY, LIQUID; CROSS-OVER STUDIES; DRUG STABILITY; HUMANS; LORATADINE; MALE; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; TABLETS; TANDEM MASS SPECTROMETRY; THERAPEUTIC EQUIVALENCY;

EID: 35548994954     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.07.012     Document Type: Article

References (12)

1. McClellan K., and Jarvis B. Drugs 61 (2001) 789-796
2. Geha R., and Meltzer E. J. Allergy Clin. Immunol. 107 (2001) 751-762
3. http://www.fda.gov/cder/foi/label/2005/021312s007lbl.pdf
4. El-Sherbiny D.T., El-Enany N., Belal F.F., and Hansen S.H. J. Pharm. Biomed. Anal. 43 (2007) 1236-1242
5. Qi M.L., Wang P., and Geng Y.S. J. Pharm. Biomed. Anal. 38 (2005) 355-359
6. Liu L.H., Qi M.L., Wang P., and Li H.Z. J. Pharm. Biomed. Anal. 34 (2004) 1013-1019
7. Yin O.Q.P., Shi X.J., and Chow M.S.S. J. Chromatogr. B 796 (2003) 165-172
8. Yang L.Y., Clement R.P., Kantesaria B., Reyderman L., Beaudry F., Grandmaison C., Donato L.D., Masse R., and Rudewicz P.J. J. Chromatogr. B 792 (2003) 229-240
9. Shen J.X., Wang H.P., Tadros S., and Hayes R.N. J. Pharm. Biomed. Anal. 40 (2006) 689-706
10. Sutherland F.C.W., de Jager A.D., Badenhorst D., Scanes T., Hundt H.K.L., Swart K.J., and Hundt A.F. J. Chromatogr. A 914 (2001) 37-43
11. Yeh G.C., Deng S.T., Lo C.Y., Chiang P.S., and Hsiong C.H. Arzneim. Forsch. 54 (2004) 166-170
12. Gupta S., Banfield C., Affrime M., Marbury T., Padhi D., and Glue P. Clin. Pharmacokinet. 41 (2002) 7-12