Phase equilibrium and protein partitioning in aqueous two-phase systems containing ammonium carbamate and block copolymers PEO-PPO-PEO

Biochemical Engineering Journal

Volumn 37, Issue 3, 2007, Pages 311-318

  de Oliveira, Mayra Codo ^a   de Abreu Filho, Manoel Américo Nogueira ^a   Pessôa Filho, Pedro de Alcântara ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Aqueous two phase systems; Downstream processing; Polymer; Protein; Salt

Indexed keywords

AQUEOUS TWO PHASE SYSTEMS; BOVINE SERUM ALBUMINS; DOWNSTREAM PROCESSINGS; POLYMER CHAIN SIZES;

BLOCK COPOLYMERS; PHASE DIAGRAMS; PHASE EQUILIBRIA; POLYETHYLENE OXIDES; SALTS; TEMPERATURE MEASUREMENT; TWO PHASE FLOW;

PROTEINS;

AMMONIUM CARBAMATE; AMMONIUM DERIVATIVE; BETA LACTOGLOBULIN; CARBAMIC ACID DERIVATIVE; COPOLYMER; IMMUNOGLOBULIN; LACTALBUMIN; LYSOZYME; SERUM ALBUMIN; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; DOWNSTREAM PROCESSING; EQUILIBRIUM CONSTANT; LIQUID LIQUID EXTRACTION; PARTITION COEFFICIENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; TEMPERATURE SENSITIVITY;

BOVINAE;

EID: 35548991337     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2007.05.010     Document Type: Article

References (25)

1. Albertsson P.-A. Partition of cell particles and macromolecules. Third ed. (1986), Wiley, New York
2. Gu Z.-R., and Glatz C.E. Aqueous two-phase extraction for protein recovery from corn extracts. J. Chromatogr. B 845 (2007) 38-50
3. Rosa P.A.J., Azevedo A.M., and Aires Barros M.R. Application of central composite design to the optimisation of aqueous two-phase extraction of human antibodies. J. Chromatogr. A 1141 (2007) 50-60
4. Cavalcanti M.T.H., Porto T.S., Neto B.D., Lima-Filho J.L., Porto A.L.F., and Pessoa Jr. A. Aqueous two-phase systems extraction of α-toxin from Clostridium perfringens type A. J. Chromatogr. B 833 (2006) 135-140
5. Frerix A., Geilenkirchen P., Muller M., Kula M.R., and Hubbuch J. Separation of genomic DNA, RNA, and open circular plasmid DNA from supercoiled plasmid DNA by combining denaturation, selective renaturation and aqueous two-phase extraction. Biotechnol. Bioeng. 96 (2007) 57-66
6. Bai H., Yang F., and Yang X. Novel prefractionation method can be used in proteomic analysis. J. Proteome Res. 5 (2006) 840-845
7. Hernandez-Mireles T., and Rito-Palomares M. New aqueous two-phase systems based on poly(ethylene oxide sulfide) (PEOS) and potassium phosphate for the potential recovery of proteins. J. Chem. Technol. Biotechnol. 81 (2006) 997-1002
8. Deng G., Yao S.J., and Lin D.Q. Partitioning of proteins using a hydrophobically modified ethylene oxide/SDS aqueous two-phase system. World J. Microbiol. Biotechnol. 21 (2005) 1209-1214
9. Skuse D.R., Norrisjones R., Yalpani M., and Brooks D.E. Hydroxypropyl cellulose poly(ethylene glycol)-co-poly(propylene glycol) aqueous 2-phase systems -system characterization and partition of cells and proteins. Enzyme Microbiol. Technol. 14 (1992) 785-790
10. Kitahara T., Kamihira M., and Takeuchi H. Application of pluronic F68 for aqueous two-phase extraction of proteins. J. Chem. Eng. Jpn. 26 (1993) 183-188
11. Svensson M., Linse P., and Tjerneld F. Phase behavior in aqueous two-phase systems containing micelle-forming block-copolymers. Macromolecules 28 (1995) 3503-3597
12. Svensson M., Joabsson F., Linse P., and Tjerneld F. Partitioning of hydrophobic amino acids and oligopeptides in aqueous two-phase system containing self-aggregating block copolymer -Effects of temperature, salts and surfactants. J. Chromatogr. A 761 (1997) 91-101
13. Svensson M., Berggren K., Veide A., and Tjerneld F. Aqueous two-phase systems containing self-associating block copolymers -partitioning of hydrophilic and hydrophobic biomolecules. J. Chromatogr. A. 839 (1999) 71-83
14. Haraguchi L.H., Mohamed R.S., Loh W., and Pessôa Filho P.A. Phase equilibrium and insulin partitioning in aqueous two-phase systems containing block copolymers and potassium phosphate. Fluid Phase Equilib. 215 (2004) 1-15
15. Silva L.H.M., Silva M.C.H., Mesquita A.F., Nascimento K.S., Coimbra J.S.R., and Minim L.A. Equilibrium phase behavior of triblock copolymer + salt + water two-phase systems at different temperatures and pH. J. Chem. Eng. Data 50 (2005) 1457-1461
16. 4. J. Chem. Eng. Data 51 (2006) 2260-2264
17. Tada E.S., Loh W., and Pessoa Filho P.A. Phase equilibrium in aqueous two-phase systems containing ethylene oxide-propylene oxide block copolymers and dextran. Fluid Phase Equilib. 218 (2004) 221-228
18. van Berlo M., Luyben K.C.A.M., and van der Wielen L.A.M. Poly(ethylene glycol)-salt aqueous two-phase systems with easily recyclable volatile salts. J. Chromatogr. B 711 (1998) 61-68
19. van Berlo M., Ottens M., Luyben K.C.A.M., and van der Wielen L.A.M. Partitioning behavior of amino acids in aqueous two-phase systems with recyclable volatile salts. J. Chromatrogr. B 743 (2000) 317-325
20. Dallora N.L.P., Klemz J.G.D., and Pessoa Filho P.A. Partitioning of model proteins in aqueous two-phase systems containing polyethylene glycol and ammonium carbamate. Biochem. Eng. J. 34 (2007) 92-97
21. Tomasula P.M., Craig Jr. J.C., and McAloon A.J. Economic analysis of a continuous casein process using carbon dioxide as precipitant. J. Dairy Sci. 81 (1998) 3331-3342
22. Andrews B.A., Schmidt A.S., and Asenjo J.A. Correlation for the partition behavior of proteins in aqueous two-phase systems: effect of surface hydrophobicity and charge. Biotechnol. Bioeng. 90 (2005) 380-390
23. Watanabe E.O., Pessôa Filho P.A., Miranda E.A., and Mohamed R.S. Evaluation of the use of volatile electrolyte system produced by ammonia and carbon dioxide in water for the salting-out of proteins: precipitation of porcine trypsin. Biochem. Eng. J. 30 (2006) 124-129
24. Rodrigues L.R., Venâncio A., and Teixeira J.A. Partitioning and separation of α-lactalbumin and β-lactoglobulin in polyethylene glycol/ammonium sulfate aqueous two-phase systems. Biotechnol. Lett. 23 (2001) 1893-1897
25. Alexandridis P., Holzwarth J.F., and Hatton T.A. Miccelization of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) in aqueous solutions: thermodynamics of copolymer association. Macromolecules 27 (1994) 2414-2425