Regulation of NF-κB pathway in T lymphocytes;Mécanismes régulateurs de la voie NF-κB dans les lymphocytes T

Medecine/Sciences

Volumn 23, Issue 10, 2007, Pages 857-861

  Lobry, Camille ^a   Weil, Robert ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 10;

CELL ACTIVATION; PHOSPHORYLATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; UBIQUITINATION;

EID: 35548966021     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.1051/medsci/20072310857     Document Type: Review

References (30)

1. Karin M. Nuclear factor-kappaB in cancer development and progression. Nature 2006 ; 441 : 431-6.
2. Weil R, Israël A. Deciphering the pathway from the TCR to NF-kappaB. Cell Death Diff 2006 ; 13 : 826-33.
3. Basak S, Kim H, Kearns JD, et al. A fourth IkappaB protein within the NF-kappaB signaling module. Cell 2007 ; 128 : 369-81.
4. Medeiros RB, Burbac BJ, Mueller KL, et al. Regulation of NF-kappaB octivation in T cells via association of the adapter proteins ADAP and CARMA1. Science 2007 ; 316 : 754-8.
5. Sun Z, Arendt CW, Ellmeier W, et al. PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature 2000 ; 404 : 402-7.
6. 2+ mobilization and NFAT cell activation in primary mouse T cells. J Exp Med 2003 ; 197 : 1525-35.
7. Bi K, Tanaka Y, Coudronniere N, et al. Antigen-induced translocation of PKC-theta to membrane rafts is required for T cell activation. Nat Immunol 2001 ; 2 : 556-63.
8. Thome M. The immunological synapse and actin assembly : a regulatory role for PKC theta. Dev Cell 2003 ; 4 : 3-5.
9. Lobry C, Weil R. New Bcl10 regulation mechanisms : a step in the comprehension of which has occurred in MALT lymphomas? Med Sci (Paris) 2007 ; 23 : 353-5.
10. Ruland J, Duncan GS, Elia A, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell 2001 ; 104 : 33-42.
11. Gaide O, Favier B, Legler DF, et al. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappaB activation. Nat Immunol 2002 ; 3 : 836-43.
12. Lee KY, D'Acquisto F, Hayden MS, et al. PDK1 nucleates T cell receptor-induced signaling complex for NF-kappaB activation. Science 2005 ; 308 : 114-8.
13. Egawa T, Albrecht B, Favier B, et al. Requirement for CARMA1 in antigen receptor-induced NF-kappaB activation and lymphocyte proliferation. Curr Biol 2003 ; 13 : 1252-8.
14. Hara H, Wada T, Bakal C, et al. The MAGUK family protein CARD11 is essential for lymphocyte activation. Immunity 2003 ; 18 : 763-75.
15. Jun JE, Wilson LE, Vinuesa CG, et al. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 2003 ; 18 : 751-62.
16. Lucas PC, Yonezumi M, Inohara N, et al. Bcl10 and MALT1, independent targets of chromosomal translocation in MALT lymphoma, cooperate in a novel NF-kappaB signaling pathway. J Biol Chem 2001 ; 276 : 19012-9.
17. Uren AG, O'Rourke K, Aravind LA, et al. Identification of paracaspases and metacaspases : two ancient families of caspase-like proteins, one of which plays a key role in MALT lymphoma. Mol Cell 2000 ; 6 : 961-7.
18. Ruefli-Brasse AA, French DM, Dixit VM. Regulation of NF-kappaB-dependent lymphocyte activation and development by paracaspase. Science 2003 ; 302 : 1581-4.
19. Ruland J, Duncan GS, Wakeham A, Mak TW. Differential requirement for Malt1 in T and B cell antigen receptor signaling. Immunity 2003 ; 19 : 749-58.
20. Huang J, Lo PF, Zal T, et al. CD28 plays a critical role in the segregation of PKC theta within the immunologic synapse. Proc Natl Acad Sci USA 2002 ; 99 : 9369-73.
21. Pomerantz JL, Denny EM, Baltimore D. CARD11 mediates factor-specific activation of NF-kappaB by the T cell receptor complex. EMBO J 2002 ; 21 : 5184-94.
22. Wang D, Matsumoto R, You Y, et al. CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10 and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol 2004 ; 24 : 164-71.
23. Weil R, Schwamborn K, Alcover A, et al. Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor. Immunity 2003 ; 18 : 13-26.
24. Chun HJ, Zheng L, Ahmad M, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature 2002 ; 419 : 395-9.
25. Su H, Bidère N, Zheng L, et al. Requirement for caspase-8 in NF-kappaB activation by antigen receptor. Science 2005 ; 307 : 1465-8.
26. Bidère N, Snow AL, Sakai K, et al. Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Curr Biol 2006 ; 16 : 1666-71.
27. Thome M, Weil R. Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol 2007 ; 28 : 281-8.
28. Wegener E, Oeckinghaus A, Papadopoulou N, et al. Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell 2006 ; 23 : 13-23.
29. Lobry C, Lopez T, Israël A, Weil R. Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10. Proc Natl Acad Sci USA 2007 ; 104 : 908-13.
30. Zhou H, Wertz I, O'Rourke K, et al. Bcl10 activates NF-kappaB pathway through paracaspase/MALT1 dependent ubiquitination of NEMO/ IKKgamma. Nature 2004 ; 427 : 167-71.