Kinetics of cryptdin-4 translocation coupled with peptide-induced vesicle leakage

Biochemistry

Volumn 46, Issue 42, 2007, Pages 11882-11891

  Cummings, Jason E ^a   Vanderlick, T Kyle ^a  

^a Princeton University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPID MOLAR RATIO; MEMBRANE PERMEABILITY; MEMBRANE PERTURBATION; TRANSLOCATION KINETICS;

BIOLOGICAL MEMBRANES; DIMERIZATION; FLUOROPHORES; PHOSPHOLIPIDS;

PEPTIDES;

ALPHA DEFENSIN; CRYPTDIN 4; FLUORESCENT DYE; LIPID; PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; DIMERIZATION; KINETICS; LIPID MEMBRANE; MEMBRANE PERMEABILITY; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN TRANSPORT; SECRETORY VESICLE;

ALPHA-DEFENSINS; ANIMALS; ANTI-INFECTIVE AGENTS; CELL MEMBRANE PERMEABILITY; DITHIONITE; FLUORESCENCE RESONANCE ENERGY TRANSFER; KINETICS; LIPID BILAYERS; LIPOSOMES; MICE; MODELS, STATISTICAL; PEPTIDES; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; PROTEIN BINDING;

EID: 35448996613     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi701110m     Document Type: Article

References (34)

1. Lehrer, R. I., Barton, A., Daher, K. A., Harwig, S. S. L., Ganz, T., and Selsted, M. E. (1989) Interactions of human defensins with Escherichia coli. Mechanism of bactericidal activity, J. Clin. Invest. 84, 553-561.
2. Ring, A., and Sandblom, J. (1988) Evaluation of surface tension and ion occupancy effects on gramicidin A channel lifetime, Biophys. J. 53, 541-548.
3. Portlock, S. H., Clague, M. J., and Cherry, R. J. (1990) Leakage of internal markers from erythrocytes and lipid vesicles induced by melittin, gramicidin S and alamethicin: A comparative study, Biochim. Biophys. Acta 1030, 1-10.
4. Wimley, W. C., Selsted, M. E., and White, S. H. (1994) Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores, Protein Sci. 3, 1362-1373.
5. Fattal, E., Nir, S., Parente, R. A., and Szoka, F. C., Jr. (1994) Pore-forming peptides induce rapid phospholipid flip-flop in membranes, Biochemistry 33, 6721-6731.
6. Matsuzaki, K., Mitani, Y., Akada, K.-y., Murase, O., Yoneyama, S., Zasloff, M., and Miyajima, K. (1998) Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa, Biochemistry 37, 15144-15153.
7. Matsuzaki, K., Murase, O., and Miyajima, K. (1995) Kinetics of pore formation by an antimicrobial peptide, magainin 2, in phospholipid bilayers, Biochemistry 34, 12553-12559.
8. Matsuzaki, K., Yoneyama, S., and Miyajima, K. (1997) Pore formation and translocation of melittin, Biophys. J. 73, 831-838.
9. Matsuzaki, K., Murase, O., Fujii, N., and Miyajima, K. (1995) Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore, Biochemistry 34, 6521-6526.
10. Yue, G., Merlin, D., Selsted, M. E., Lencer, W. I., Madara, J. L., and Eaton, D. C. (2002) Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells, Am. J. Physiol. 282, 757-765.
11. Ghosh, J. K., Shaool, D., Guillaud, P., Ciceron, L., Mazier, D., Kustanovich, I., Shai, Y., and Mor, A. (1997) Selective cytotoxicity of dermaseptin S3 toward intraerythrocytic Plasmodium falciparum and the underlying molecular basis, J. Biol. Chem. 272, 31609-31616.
12. Pokorny, A., Birkbeck, T. H., and Almeida, F. F. (2002) Mechanism and kinetics of δ-lysin interaction with phospholipid vesicles, Biochemistry 41, 11044-11056.
13. Lehrer, R. I., Lichtenstein, A. K., and Ganz, T. (1993) Defensins: Antimicrobial and cytotoxic peptides of mammalian cells, Annu. Rev. Immunol. 11, 105-128.
14. Ouellette, A. J., Hsieh, M. M., Nosek, M. T., Cano-Gauci, D. F., Huttner, K. M., Buick, R. N., and Selsted, M. E. (1994) Mouse paneth cell defensins: Primary structures and antibacterial activities of numerous cryptdin isoforms, Infect. Immun. 62, 5040-5047.
15. Jing, W., Hunter, H. N., Tanabe, H., Ouellette, A. J., and Vogel, H. J. (2004) Solution structure of cryptdin-4, a mouse paneth cell α-defensin, Biochemistry 43, 15759-15766.
16. Maemoto, A., Qu, X., Rosengren, K. J., Tanabe, H., Henschen-Edman, A., Craik, D. J., and Ouellette, A. J. (2004) Functional analysis of the α-defensin disulfide array in mouse cryptdin-4, J. Biol. Chem. 279, 44188-44196.
17. Rosengren, K. J., Daly, N. L., Fornander, L. M., Jonsson, L. M. H., Shirafuji, Y., Qu, X., Vogel, H. J., Ouellette, A. J., and Craik, D. J. (2006) Structural and functional characterization of the conserved salt bridge in mammalian paneth cell α-defensins: Solution structures of mouse cryptdin-4 and (E15D)-cryptdin-4, J. Biol. Chem. 281, 28068-28078.
18. Satchell, D. P., Sheynis, T., Kolusheva, S., Cummings, J. E., Vanderlick, T. K., Jelinek, R., Selsted, M. E., and Ouellette, A. J. (2003) Quantitative interactions between cryptdin-4 amino terminal variants and membranes, Peptides 24, 1795-1805.
19. Satchell, D. P., Sheynis, T., Shirafuji, Y., Kolusheva, S., Ouellette, A. J., and Jelinek, R. (2003) Interactions of mouse paneth cell α-defensins and α-defensin precursors with membranes, J. Biol. Chem. 278, 13838-13846.
20. Tanabe, H., Qu, X., Weeks, C. S., Cummings, J. E., Kolusheva, S., Walsh, K. B., Jelinek, R., Vanderlick, T. K., and Ouellette, A. J. (2004) Structure-activity determinants in paneth cell α-defensins: Loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions, J. Biol. Chem. 279, 11976-11983.
21. Weeks, C. S., Tanabe, H., Cummings, J. E., Crampton, S. P., Sheynis, T., Jelinek, R., Vanderlick, T. K., Cocco, M. J., and Ouellette, A. J. (2006) Matrix metalloproteinase-7 activation of mouse paneth cell pro-α-defensins: Ser43↓Ile44 proteolysis enables membrane-disruptive activity, J. Biol. Chem. 281, 28932-28942.
22. Drin, G., and Temsamani, J. (2002) Translocation of protegrin I through phospholipid membranes: Role of peptide folding, Biochim. Biophys. Acta 1559, 160-170.
23. Matsuzaki, K., Yoneyama, S., Murase, O., and Miyajima, K. (1996) Transbilayer transport of ions and lipids coupled with mastoparan X translocation, Biochemistry 35, 8450-8456.
24. Yeaman, M. R., and Yount, N. Y. (2003) Mechanisms of antimicrobial peptide action and resistance, Pharmacol. Rev. 55, 27-55.
25. Ladokhin, A. S., Jayasinghe, S., and White, S. H. (2000) How to measure and analyze tryptophan fluorescence in membranes properly, and why bother? Anal. Biochem. 285, 235-245.
26. Montal, M., and Mueller, P. (1972) Formation of bimolecular membranes from lipid monolayers and a study of their electrical properties, Proc. Natl. Acad. Sci. U.S.A. 69, 3561-3566.
27. Bezrukov, S. M., and Vodyanoy, I. (1993) Probing alamethicin channels with water-soluble polymers. Effect on conductance of channel states, Biophys. J. 64, 16-25.
28. Smolarsky, M., Teitelbaum, D., Sela, M., and Gitler, C. (1977) A simple fluorescent method to determine complement-mediated liposome immune lysis, J. Immunol. Methods 15, 255-265.
29. Ladokhin, A. S., Wimley, W. C., Hristova, K., and White, S. H. (1997) Mechanism of leakage of contents of membrane vesicles determined by fluorescence requenching, Methods Enzymol. 278, 474-486.
30. Ladokhin, A. S., Wimley, W. C., and White, S. H. (1995) Leakage of membrane vesicle contents: Determination of mechanism using fluorescence requenching, Biophys. J. 69, 1964-1971.
31. Kolusheva, S., Shahal, T., and Jelinek, R. (2000) Peptide-membrane interactions studied by a new phospholipid/polydiacetylene colorimetric vesicle assay, Biochemistry 39, 15851-15859.
32. Apel-Paz, M., Doncel, G. F., and Vanderlick, T. K. (2003) Membrane perturbation by surfactant candidates for STD prevention, Langmuir 19, 591-597.
33. Mileykovskaya, E., and Dowhan, W. (2000) Visualization of phospholipid domains in Escherichia coli by using the cardiolipin-specific fluorescent dye 10-n-nonyl acridine orange, J. Bacteriol. 182, 1172-1175.
34. Cummings, J. E., Satchell, D. P., Shirafuji, Y., Ouellette, A. J., and Vanderlick, T. K. (2003) Electrostatically controlled interactions of mouse paneth cell α-defensins with phospholipid membranes, Aust. J. Chem. 56, 1031-1034.