Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

Journal of Anatomy

Volumn 211, Issue 5, 2007, Pages 620-629

  Jenkins, Dagan ^a   Winyard, Paul J D ^a   Woolf, Adrian S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Bladder; Collecting duct; Smooth muscle; Uroplakin; Urothelium

Indexed keywords

CYCLIN B1; MEMBRANE PROTEIN; PROTEIN PATCHED; PROTEIN SMOOTHENED; SONIC HEDGEHOG PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DETRUSOR MUSCLE; DOWN REGULATION; EMBRYO; FETUS; GENE EXPRESSION REGULATION; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY COLLECTING TUBULE; KIDNEY DEVELOPMENT; NORMAL HUMAN; ORGANOGENESIS; PARACRINE SIGNALING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; URINARY TRACT DEVELOPMENT; UROGENITAL SINUS; UROTHELIUM;

BIOLOGICAL MARKERS; CYCLIN B; FEMALE; FETAL DEVELOPMENT; GESTATIONAL AGE; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; PREGNANCY; PROLIFERATING CELL NUCLEAR ANTIGEN; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; URINARY TRACT;

ERINACEIDAE;

EID: 35448976397     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/j.1469-7580.2007.00808.x     Document Type: Article

References (41)

1. Bacanli A, Ciftcioglu MA, Savas B, Alpsoy E (2005) Nevoid basal cell carcinoma syndrome associated with unilateral renal agenesis: acceleration of basal cell carcinomas following radiotherapy. J Eur Acad Dermatol Venereol 19, 510-511.
2. Barnes EA, Heidtman KJ, Donoghue DJ (2005) Constitutive activation of the shh-ptc1 pathway by a patched1 mutation indentified in BCC. Oncogene 24, 902-915.
3. Barnes EA, Kong M, Ollendorff V, Donoghue DJ (2001) Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO 20, 2214-2223.
4. Bijlsma MF, Spek CA, Zivkovic D, van de Water S, Rezaee F, Peppelenbosch MP (2006) Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion. PLoS Biol 4, e232.
5. Bitgood MJ, McMahon AP (1995) Hedgehog and Bmp genes are expressed at many diverse sites of cell-cell interaction in mouse embryos. Dev Biol 172, 126-138.
6. Cajaiba MM, Bale AE, Alvarez-Franco M, McNamara J, Reyes-Mugica M (2006) Rhabdomyosarcoma, Wilms tumor, and deletion of the patched gene in Gorlin syndrome. Nat Clin Pract Oncol 3, 575-580.
7. Cooper MK, Wassif CA, Krakowiak PA, et al. (2003) A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nature Genet 33, 508-513.
8. Dubourg C, Lazaro L, Pasquier L, et al. (2004) Molecular screening of SHH, ZIC2, SIX3 and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations. Hum Mutat 24, 43-51.
9. Dudley AT, Robertson EJ (1997) Overlapping expression domains of bone morphogenetic protein family members potentially account for limit tissue defects in BMP7 deficient embryos. Dev Dyn 208, 349-362.
10. Gritli-Linde A, Lewis P, McMahon AP, Linde A (2001) The whereabouts of a morphogen: Direct evidence for short-and graded long-range activity of hedgehog signaling peptides. Dev Biol 236, 364-386.
11. Guy RK (2000) Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation. Proc Natl Acad Sci USA 97, 7303-7312.
12. Haraguchi R, Motoyama J, Sasaki H, et al. (2007) Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development 34, 525-533.
13. Hu MC, Mo R, Bhella S, Wilson CW, Chuang PT, Hui CC, et al. (2005) GLI3-dependent transcriptional repression of Gli1, Gli2 and kidney patterning genes disrupts renal morphogenesis. Development 133, 569-578.
14. Ingham PW, McMahon AP (2001) Hedgehog signalling in animal development: paradigms and principles. Genes Dev 15, 3059-3087.
15. Ingham PW, Placzek M (2006) Orchestrating ontogenesis: Variations on a theme by sonic hedgehog. Nat Rev Genet 7, 841-850.
16. Jenkins D (2006) The genetics of human renal tract malformations. PhD thesis, London: University of London, pp. 1-254.
17. Jenkins D, Bitner-Glindzicz M, Malcolm S, et al. (2005) De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. J Am Soc Nephrol 16, 2141-2149.
18. Johnston JJ, Olivos-Glander I, Killoran C, et al. (2005) Molecular and clinical analyses of Grieg cephalopolysyndactyly and Pallister-Hall syndromes: Robust phenotype prediction from the type and position of GLI3 mutations. Am J Hum Genet 76, 609-622.
19. Kelley RI, Hennekam RC (2000) The Smith-Lemli-Opitz syndrome. J Med Genet 37, 321-335.
20. Kim J, Kim P, Hui CC (2001) The VACTERL association: Lessons from the Sonic hedgehog pathway. Clin Genet 59, 306-315.
21. Lamm ML, Podlasek CA, Barnett DH, et al. (2001) Mesenchymal factor bone morphogenetic protein 4 restricts ductal budding and branching morphogenesis in the developing prostate. Dev Biol 232, 301-314.
22. Lindsay S, Copp AJ (2005) MRC-Wellcome Trust Human Developmental Biology Resource: Enabling studies of human developmental gene expression. Trends Genet 21, 586-590.
23. Miyazaki Y, Oshima K, Fogo A, Ichikawa I (2003) Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development. Kidney Int 63, 835-844.
24. Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I (2000) Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 105, 863-873.
25. Mo R, Kim JH, Zhang J, Chiang C, Hui CC, Kim PC (2001) Anorectal malformations caused by defects in sonic hedgehog signaling. Am J Pathol 159, 765-774.
26. Munro J, Steeghs K, Morrison V, Ireland H, Parkinson EK (2001) Human fibroblast replicative senescence cann occur in the absence of extensive cell division and short telomeres. Oncogene 20, 3541-3552.
27. Nakashima M, Tanese N, Ito M, et al. (2002) A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development. Mech Dev 119, 21-34.
28. Nieuwenhuis E, Hui CC (2004) Hedgehog signalling and congenital malformations. Clin Genet 67, 193-208.
29. Oniscu A, James RM, Morris RG, Bader S, Malcomson RD, Harrison DJ (2004) Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia. J Pathol 203, 909-917.
30. Raatikainen-Ahokas A, Hytonen M, Tenhunen A, Sainio K, Sariola H (2000) BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney. Dev Dyn 217, 146-158.
31. Romih R, Korosec P, de Mello W Jr, Jezernik K (2005) Differentiation of epithelial cells within the urinary tract. Cell Tissue Res 320, 259-268.
32. Santis HR, Nathanson NR, Bauer SB (1983) Nevoid basal cell carcinoma syndrome associated with renal cysts and hypertension. Oral Surg Oral Med Oral Pathol 55, 127-132.
33. Sukegawa A, Narita T, Kameda T, et al. (2000) KThe concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127, 1971-1980.
34. Taipale J, Chen JK, Cooper MK, et al. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005-1009.
35. Thibert C, Teillet MA, Lapointe F, Mazelin L, Le Douarin NM, Mehlen P (2003) Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 301, 843-846.
36. van den Brink GR, Bleuming SA, Hardwick JC, et al. (2005) Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation. Nat Genet 36, 277-282.
37. van den Brink GR, Hardwick JC, Tytgat GN, Brink MA, Ten Kate FJ, Van Deventer SJ, et al. (2001) Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 121, 317-328.
38. Villavicencio EH, Walterhouse DO, Iannaccone PM (2000) The sonic hedgehog-Patched-Gli pathway in human development and disease. Am J Hum Genet 67, 1047-1054.
39. Woolf AS, Jenkins D (2006) Chapter 2. Development of the kidney. In Heptinstall's Pathology of the Kidney, 6th edition (eds Jennette JC, Olson JL, Schwartz MM, Silva FG), pp. 71-95. Philadelphia-New York, USA: Lippincott-Raven.
40. Wu XR, Lin JH, Walz T, Haner M, Yu J, Aebi U, Sun TT (1994) Mammalian uroplakins. A group of highly conserved urothelial differentiation-related membrane proteins. J Biol Chem 269, 13716-13724.
41. Yu J, Carroll TJ, McMahon AP (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129, 5301-5312.