-
1
-
-
0001903028
-
"The complexities of AIDS: An assessment of the HIV protease as a Therapeutic Target"
-
A.G Tomasselli, W.J. Howe, T.K. Sawyer, A. Wlodawer and R.L. Heinrikson: "The complexities of AIDS: An assessment of the HIV protease as a Therapeutic Target", Chimica Ogg., Vol. 9, (1991), pp. 6-27.
-
(1991)
Chimica Ogg.
, vol.9
, pp. 6-27
-
-
Tomasselli, A.G.1
Howe, W.J.2
Sawyer, T.K.3
Wlodawer, A.4
Heinrikson, R.L.5
-
2
-
-
0025952925
-
"HIV Protease A Novel chemotherapeutic Target for AIDS"
-
J.R. Huff: "HIV Protease A Novel chemotherapeutic Target for AIDS", J. Med. Chem., Vol. 34, (1991), pp. 2305-2314.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2305-2314
-
-
Huff, J.R.1
-
3
-
-
77956796531
-
"HIV Protease Inhibitors"
-
D.W. Norbeck and D.J. Kempf: "HIV Protease Inhibitors", Annu. Rep, Med. Chem., Vol. 26, (1991), pp. 141-160.
-
(1991)
Annu. Rep, Med. Chem.
, vol.26
, pp. 141-160
-
-
Norbeck, D.W.1
Kempf, D.J.2
-
4
-
-
0026579208
-
"The HIV-1 protease as a therapeutic target for AIDS"
-
C. Debouck: "The HIV-1 protease as a therapeutic target for AIDS", AIDS Res. Hum. Retroviruses., Vol. 8, (1992), pp. 153-164.
-
(1992)
AIDS Res. Hum. Retroviruses.
, vol.8
, pp. 153-164
-
-
Debouck, C.1
-
5
-
-
0028264163
-
"The retroviral enzymes"
-
R.A. Katz and A.M. Skalka: "The retroviral enzymes", Annu. Rev. Biochem., Vol. 63, (1994), pp. 133-173.
-
(1994)
Annu. Rev. Biochem.
, vol.63
, pp. 133-173
-
-
Katz, R.A.1
Skalka, A.M.2
-
6
-
-
0028811974
-
"Viral Dynamics in Human Immunodeficiency virus type-1 infection"
-
X. Wei, S.K. Gosh, M.E. Taylor, V.A. Johnson, E.A. Emini, P. Deutsch, J.D. Lifson, S. Bonhoeffer, M.A. Nowak, B.H. Hahn, M.S. Saag and G.M. Shaw: "Viral Dynamics in Human Immunodeficiency virus type-1 infection", Nature, Vol. 373, (1995), pp. 117-122.
-
(1995)
Nature
, vol.373
, pp. 117-122
-
-
Wei, X.1
Gosh, S.K.2
Taylor, M.E.3
Johnson, V.A.4
Emini, E.A.5
Deutsch, P.6
Lifson, J.D.7
Bonhoeffer, S.8
Nowak, M.A.9
Hahn, B.H.10
Saag, M.S.11
Shaw, G.M.12
-
7
-
-
0028874048
-
"Rapid turnover of Plasma Virons and CD4 lymphocytes in HIV-1 Infection"
-
D.D. Ho, A.U. Neumann, A.S. Perelson, W. Chen, J.M. Leonard and M. Markowitz: "Rapid turnover of Plasma Virons and CD4 lymphocytes in HIV-1 Infection", Nature, Vol. 373, (1995), pp. 123-126.
-
(1995)
Nature
, vol.373
, pp. 123-126
-
-
Ho, D.D.1
Neumann, A.U.2
Perelson, A.S.3
Chen, W.4
Leonard, J.M.5
Markowitz, M.6
-
8
-
-
0028968902
-
"ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease with high oral Bioavailability in Humans"
-
D. Kempf, K.C. Marsh, J.F. Denissen, E. McDonald, S. Vasavanonda, C.A. Flentge, B.G. Green, L. Fino, C. H. Park, X.P. Kong, N.E. Wideburg, A. Saldivar, L. Ruiz, W.M. Kati, H.L. Sham, T. Robins, K.D. Stewart, A. Hsu, J.J. Plattner, J.M. Leonard, D.W. Norbeck: "ABT-538 is a Potent Inhibitor of Human Immunodeficiency Virus Protease with high oral Bioavailability in Humans", Proc. Natl. Acad. Sci. U.S.A., Vol. 92, (1995), pp. 2484-2488.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 2484-2488
-
-
Kempf, D.1
Marsh, K.C.2
Denissen, J.F.3
McDonald, E.4
Vasavanonda, S.5
Flentge, C.A.6
Green, B.G.7
Fino, L.8
Park, C.H.9
Kong, X.P.10
Wideburg, N.E.11
Saldivar, A.12
Ruiz, L.13
Kati, W.M.14
Sham, H.L.15
Robins, T.16
Stewart, K.D.17
Hsu, A.18
Plattner, J.J.19
Leonard, J.M.20
Norbeck, D.W.21
more..
-
9
-
-
0025054246
-
"Structure based design of Nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease"
-
E. Rutenber, E.B. Fauman, R.J. Keenan, S. Fong, S.P. Furth., P.R. Oritiz de Montellano, D.L. DeCamp, L.M. Babe and C.S. Craik: "Structure based design of Nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease", Proc. Natl. Acad. Sci USA, Vol. 87, (1990), pp. 6644-6648.
-
(1990)
Proc. Natl. Acad. Sci USA
, vol.87
, pp. 6644-6648
-
-
Rutenber, E.1
Fauman, E.B.2
Keenan, R.J.3
Fong, S.4
Furth, S.P.5
Oritiz de Montellano, P.R.6
DeCamp, D.L.7
Babe, L.M.8
Craik, C.S.9
-
10
-
-
0026610963
-
"Penicillin Derived C2 symmetrical Dimers as Novel Inhibitors of HIV-1 Proteinase"
-
D.C. Humber, N. Cammack, J. Coates, K.N. Cobley, D.C. Orr, R. Storer, G.G. Weingarten and M.P. Weir: "Penicillin Derived C2 symmetrical Dimers as Novel Inhibitors of HIV-1 Proteinase", J. Med. Chem, Vol. 35, (1992), pp. 3080-3081.
-
(1992)
J. Med. Chem
, vol.35
, pp. 3080-3081
-
-
Humber, D.C.1
Cammack, N.2
Coates, J.3
Cobley, K.N.4
Orr, D.C.5
Storer, R.6
Weingarten, G.G.7
Weir, M.P.8
-
11
-
-
0028057975
-
"Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors"
-
P.Y.S. Lam, P.K. Jadhav, C.J. Eyermann, C.N. Hodge, Y. Ru, L.T. Bacheler, J.L. Meek, M.J. Otto, M.M. Rayner, Y.N. Wong, C.H. Chang, P.C. Weber, T.R. Sharpe, D.A. Jackson and S. Erickson-Viitanen: "Rational Design of Potent, Bioavailable, Nonpeptide Cyclic Ureas as HIV Protease Inhibitors", Science, Vol. 263, (1994), pp. 380-384.
-
(1994)
Science
, vol.263
, pp. 380-384
-
-
Lam, P.Y.S.1
Jadhav, P.K.2
Eyermann, C.J.3
Hodge, C.N.4
Ru, Y.5
Bacheler, L.T.6
Meek, J.L.7
Otto, M.J.8
Rayner, M.M.9
Wong, Y.N.10
Chang, C.H.11
Weber, P.C.12
Sharpe, T.R.13
Jackson, D.A.14
Erickson-Viitanen, S.15
-
12
-
-
35448989525
-
-
QikProp, version 2.5, Schrödinger, LLC, New York, NY
-
QikProp, version 2.5, Schrödinger, LLC, New York, NY, 2005.
-
(2005)
-
-
-
13
-
-
33244491256
-
"PEARLS: Program for Energetic Analysis of Receptor-Ligand System"
-
L.Y. Han, H.H. Lin, Z.R. Li, C.J. Zheng, Z.W. Cao, B. Xie and Y.Z. Chen: "PEARLS: Program for Energetic Analysis of Receptor-Ligand System", J. Chem. Inf. Model., Vol. 46, (2006), pp. 445-450.
-
(2006)
J. Chem. Inf. Model.
, vol.46
, pp. 445-450
-
-
Han, L.Y.1
Lin, H.H.2
Li, Z.R.3
Zheng, C.J.4
Cao, Z.W.5
Xie, B.6
Chen, Y.Z.7
-
14
-
-
13344295092
-
"A Novel picomolar inhibitor of Human immunodeficiency virus type-1 Protease"
-
H.L. Sham, C. Zhao, K.D. Stewert, D.A. Betebenner, S. Lin, C.H. Park, X.P. Knong, W.J. Rosenbrook, T. Herrin, D. Madigan, S. Vasavaononda, N. Lyons, A. Molla, A. Saldivar, K.C. Marsh, E. McDonald, N.E. Wideburg, J.F. Platter and D.W. Norbeck: "A Novel picomolar inhibitor of Human immunodeficiency virus type-1 Protease", J. Med. Chem., Vol. 39, (1996), pp. 392-397.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 392-397
-
-
Sham, H.L.1
Zhao, C.2
Stewert, K.D.3
Betebenner, D.A.4
Lin, S.5
Park, C.H.6
Knong, X.P.7
Rosenbrook, W.J.8
Herrin, T.9
Madigan, D.10
Vasavaononda, S.11
Lyons, N.12
Molla, A.13
Saldivar, A.14
Marsh, K.C.15
McDonald, E.16
Wideburg, N.E.17
Platter, J.F.18
Norbeck, D.W.19
-
15
-
-
0030599010
-
"A fast flexible docking method using an incremental construction algorithm"
-
M. Rarey, B. Karmer, T. Lengauer and G. Klebe: "A fast flexible docking method using an incremental construction algorithm", J. Mol. Biol., Vol. 261, (1996), pp. 470-489.
-
(1996)
J. Mol. Biol.
, vol.261
, pp. 470-489
-
-
Rarey, M.1
Karmer, B.2
Lengauer, T.3
Klebe, G.4
-
16
-
-
0032698681
-
"Two stage method for protein-ligand docking"
-
D. Hoffmann, B. Kramer, T. Washio, T. Steinmetzer, M. Rayer, T. Lengauer: "Two stage method for protein-ligand docking", J. Med. Chem., Vol. 42, (1999), pp. 4422-4433.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 4422-4433
-
-
Hoffmann, D.1
Kramer, B.2
Washio, T.3
Steinmetzer, T.4
Rayer, M.5
Lengauer, T.6
-
17
-
-
0033168443
-
"Flexible ligand docking: A multistep strategy approach"
-
J. Wang, P.A. Kollman and I.D. Kuntz: "Flexible ligand docking: A multistep strategy approach", Proteins, Vol. 36, (1999), pp. 1-19.
-
(1999)
Proteins
, vol.36
, pp. 1-19
-
-
Wang, J.1
Kollman, P.A.2
Kuntz, I.D.3
-
18
-
-
9544235162
-
2 Structure-Activity Relationship and Molecular Recognition of Cyclic Ureas"
-
2 Structure-Activity Relationship and Molecular Recognition of Cyclic Ureas", J. Med. Chem., Vol. 39, (1996), pp. 3514-3525.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3514-3525
-
-
Lam, P.Y.S.1
Ru, Yu.2
Jadhav, P.K.3
Aldrich, P.E.4
DeLucca, G.V.5
Eyermann, C.J.6
Chang, C.H.7
Emmet, G.8
Holler, E.R.9
Daneker, W.F.10
Li, L.11
Confalone, P.N.12
Bacheler, L.T.13
Rayner, M.M.14
Klabe, R.M.15
Shum, L.16
Winslow, D.L.17
Kornahouse, D.M.18
Jackson, D.A.19
Erickson-Viitanen, S.20
Hodge, C.N.21
more..
-
19
-
-
0031022510
-
"Cyclic Urea Amides: HIV-1 Protease Inhibitors with low Nanomolar Potency against both Wild type and Protease Inhibitor Resistant Mutants of HIV"
-
P.K. Jadhav, P. Ala, F.J. Woerner, C.H. Chang, S.S. Garber, E.D. Anton and L.T. Bacheler: "Cyclic Urea Amides: HIV-1 Protease Inhibitors with low Nanomolar Potency against both Wild type and Protease Inhibitor Resistant Mutants of HIV", J. Med. Chem., Vol. 40, (1997), pp. 181-191.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 181-191
-
-
Jadhav, P.K.1
Ala, P.2
Woerner, F.J.3
Chang, C.H.4
Garber, S.S.5
Anton, E.D.6
Bacheler, L.T.7
-
20
-
-
14444267317
-
"Nonpeptide Cyclic Cyanoguanidines and HIV-1 protease Inhibitors: Synthesis, Structure-Activity Relationships and X-ray Crystal Structure studies"
-
P.K. Jadhav, F.J. Woerner, P.Y.S. Lam, C.N. Hodge, C.J. Eyermann, Hon-Wah Man, W.F. Daneker, L.T. Bacheler, M.M. Rayner, J.L. Meek, S. Erickson-Viitanen, D.A. Jackson, J.C. Calabrese, M. Schadt and C.H. Chang: "Nonpeptide Cyclic Cyanoguanidines and HIV-1 protease Inhibitors: Synthesis, Structure-Activity Relationships and X-ray Crystal Structure studies", J. Med. Chem., Vol. 41, (1998), pp. 1446-1455.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1446-1455
-
-
Jadhav, P.K.1
Woerner, F.J.2
Lam, P.Y.S.3
Hodge, C.N.4
Eyermann, C.J.5
Man, H.-W.6
Daneker, W.F.7
Bacheler, L.T.8
Rayner, M.M.9
Meek, J.L.10
Erickson-Viitanen, S.11
Jackson, D.A.12
Calabrese, J.C.13
Schadt, M.14
Chang, C.H.15
-
21
-
-
0032492679
-
2 groups"
-
2 groups", Bioorg. Med. Chem. Lett., Vol. 8, (1998), pp. 715-720.
-
(1998)
Bioorg. Med. Chem. Lett.
, vol.8
, pp. 715-720
-
-
Rodgers, J.D.1
Johnson, B.L.2
Wang, H.3
Erickson-Viitanen, S.4
Klabe, R.M.5
Bacheler, L.T.6
Cordova, B.C.7
Chang, C.H.8
-
22
-
-
0032492701
-
1 groups"
-
1 groups", Bioorg. Med. Chem.Lett., Vol. 8, (1998), pp. 823-828.
-
(1998)
Bioorg. Med. Chem.Lett.
, vol.8
, pp. 823-828
-
-
Patel, M.1
Bacheler, L.T.2
Rayner, M.M.3
Cordova, B.C.4
Klabe, R.M.5
Erickson Viitanen, S.6
Sitz, S.P.7
-
23
-
-
18344405671
-
1 Cyclic Ureas as HIV protease inhibitors"
-
1 Cyclic Ureas as HIV protease inhibitors", Bioorg. Med. Chem.Lett., Vol. 8, (1998), pp. 1077-1082.
-
(1998)
Bioorg. Med. Chem.Lett.
, vol.8
, pp. 1077-1082
-
-
Patel, M.1
Kaltenbach III, R.F.2
Nugie, D.A.3
Mchugh Jr., R.J.4
Jadhav, P.K.5
Bacheler, L.T.6
Cordova, B.C.7
Klabe, R.M.8
Erickson-Viitanen, S.9
Garber, S.S.10
Ried, C.11
Sitz, S.P.12
-
24
-
-
0034673352
-
"Computational Design of New cyclic Urea Inhibitors for improved binding of HIV-1 Aspartic Protease"
-
K. Bhanuprakash, B. Irena, B. Fabio and M. Stanisalav: "Computational Design of New cyclic Urea Inhibitors for improved binding of HIV-1 Aspartic Protease", Biochem. BioPhy. Res. Comm., Vol. 268, (2000), pp. 384-389.
-
(2000)
Biochem. BioPhy. Res. Comm.
, vol.268
, pp. 384-389
-
-
Bhanuprakash, K.1
Irena, B.2
Fabio, B.3
Stanisalav, M.4
-
25
-
-
35448933390
-
"Novel high affinity p38 kinase inhibitors by virtual screening by Glide. Modeling structure and Reactivity"
-
A.H. Thomas, J.R. Greenwood, L.L. Frye, R.B. Murphy and R.A. Friesner: "Novel high affinity p38 kinase inhibitors by virtual screening by Glide. Modeling structure and Reactivity", WATOC-2005, 7th congress of the world association of theoretically oriented chemists.
-
WATOC-2005, 7th Congress of the World Association of Theoretically Oriented Chemists
-
-
Thomas, A.H.1
Greenwood, J.R.2
Frye, L.L.3
Murphy, R.B.4
Friesner, R.A.5
-
26
-
-
0031024171
-
"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings"
-
C.A. Lipinski, F. Lombardo, B.W. Dominy, P.J. Feeney: "Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings", Adv. Drug. Deliver. Rev., Vol. 23, (1997), pp. 3-25.
-
(1997)
Adv. Drug. Deliver. Rev.
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
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