The synthesis of symmetrical and unsymmetrical P1/P1' cyclic ureas as HIV protease inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 8, Issue 9, 1998, Pages 1077-1082

  Patel, Mona ^a   Kaltenbach III, Robert F ^a   Nugiel, David A ^a   McHugh Jr , Robert J ^a   Jadhav, Prabhakar K ^a   Bacheler, Lee T ^a   Cordova, Beverly C ^a   Klabe, Ronald M ^a   Erickson Viitanen, Susan ^a   Garber, Sena ^a   Reid, Carol ^a   Seitz, Steven P ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PROTEINASE INHIBITOR; SD 146; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG RESISTANCE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

BINDING SITES; BIOLOGICAL AVAILABILITY; DRUG DESIGN; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDROGEN BONDING; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

CANIS FAMILIARIS; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 18344405671     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(98)00175-9     Document Type: Article

References (8)

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3. 1H NMR, CIMS/ESIMS and HRMS/peak match) and were homogenous by TLC.
4. 2, 72 h, 96%.
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