Subharmonic Response of Encapsulated Microbubbles: Conditions for Existence and Amplification

Ultrasound in Medicine and Biology

Volumn 33, Issue 11, 2007, Pages 1767-1776

  Kimmel, Eitan ^a   Krasovitski, Boris ^a   Hoogi, Assaf ^a   Razansky, Daniel ^a   Adam, Dan ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Definity; Microbubbles; Subharmonic response; Subharmonic threshold; Ultrasound

Indexed keywords

DIAGNOSIS; MATHEMATICAL MODELS; SIZE DISTRIBUTION; ULTRASONICS;

MICROBUBBLES; SUBHARMONIC RESPONSE; SUBHARMONIC THRESHOLD;

BUBBLES (IN FLUIDS);

PERFLUTREN;

ARTICLE; FREQUENCY ANALYZER; MICROBUBBLE; MICROENCAPSULATION; PARTICLE SIZE; PRIORITY JOURNAL; THEORETICAL STUDY; ULTRASOUND;

ACOUSTICS; BIOMECHANICS; CONTRAST MEDIA; FLUOROCARBONS; HUMANS; MICROBUBBLES; MODELS, THEORETICAL;

EID: 35448950445     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2007.05.011     Document Type: Article

References (24)

1. Adam D., Sapunar M., and Burla E. On the relationship between encapsulated contrast agent and pressure. Ultrasound Med Biol 31 5 (2005) 673-686
2. Bogoliubov N.N., and Mitropolsky Y.A. Asymptotic methods in the theory of non-linear oscillations (1961), Hindustan Publishing Corporation, Delhi-6, India
3. Chatterjee D., Sarkar K., Jain P., and Schreppler N.E. On the suitability of broadband attenuation measurement for characterizing contrast microbubbles. Ultrasound Med Biol 31 (2005) 781-786
4. Chen Q., Zagrebski J., Wilson T., and Stiles T. Pressure-dependent attenuation in ultrasound contrast agents. Ultrasound Med Biol 28 (2002) 1041-1051
5. Chen W.H., and Shung K.K. The effect of low intensity ultrasound on Optison. Proc IEEE Ultrason Symp 2 (1998) 1791-1794
6. Church C.C. The effects of an elastic solid surface layer on the radial pulsations of gas bubbles. J Acoust Soc Am 97 (1995) 1510-1521
7. de Jong N. Acoustic properties of ultrasound contrast agents. Thesis (1993), Erasmus University of Rotterdam
8. Eller A., and Flynn H.G. Generation of subharmonics of order one-half by bubbles in a sound field. J Acoust Soc Am 46 Part 2 (1969) 722-727 (3)
9. Ganor Y., Adam D., and Kimmel E. Time and pressure dependence of acoustic signals radiated from microbubbles. Ultrasound Med Biol 31 (2005) 1367-1374
10. Hoff L., Sontum P.S., and Hovem J.M. Oscillations of polymeric bubbles: Effect of the encapsulating shell. J Acoust Soc Am 107 (2000) 2272-2280
11. Kabalnov A., Klein D., Pelura T., Schutt E., and Weers J. Dissolution of multicomponent microbubbles in the bloodstream: 1. Theory. Ultrasound Med Biol 24 (1998) 739-749
12. Kabalnov A., Bradley J., Flaim S., Klein D., Pelura T., Peters B., Otto S., Reynolds J., Schutt E., and Weers J. Dissolution of multicomponent microbubbles in the bloodstream: 2. Experiment. Ultrasound Med Biol 24 (1998) 751-760
13. Krasovitski B., Kimmel E., Sapunar M., and Adam D. Ultrasound attenuation by encapsulated microbubbles: Time and pressure effects. Ultrasound Med Biol 30 (2004) 793-802
14. Krasovitski B., and Kimmel E. Stability of an encapsulated bubble shell. Ultrasonics 44 (2006) 216-220
15. Krishna P.D., Shankar P.M., and Newhouse V.L. Subharmonic generation from ultrasonic contrast agents. Phys Med Biol 44 (1999) 681-694
16. Leighton T.G. The acoustic bubble (1997), Academic Press, San Diego-London
17. Medwin H. Counting bubbles acoustically: A review. Ultrasonics 15 (1977) 7-13
18. Prosperetti A. Nonlinear oscillations of gas bubbles in liquids: steady-state solutions. J Acoust Soc Am 56 (1974) 810-821
19. Prosperetti A. Application of the subharmonic threshold to the measurement of the damping of oscillating gas bubbles. J Acoust Soc Am 61 (1977) 11-15
20. Ralston A., and Wilf H. Mathematical methods for digital computers (1960), John Wiley and Sons, New York
21. Sarkar K., Shi W.T., Chatterjee D., and Forsberg F. Characterization of ultrasound contrast microbubbles using in vitro experiments and viscous and viscoelastic models for encapsulation. J Acoust Soc Am 118 (2005) 539-550
22. Shankar P.M., Krishna P.D., and Newhouse V.L. Advantages of subharmonic over second harmonic backscatter for contrast-to-tissue echo enhancement. Ultrasound Med Biol 24 (1997) 395-399
23. Shankar P.M., Krishna P.D., and Newhouse V.L. Subharmonic backscattering from ultrasound contrast agents. J Acoust Soc Am 106 (1999) 2104-2110
24. Shi W.T., Forsberg F., Raichlen J.S., Needleman L., and Goldberg B.B. Pressure dependence of subharmonic signals from contrast microbubbles. Ultrasound Med Biol 25 (1999) 275-283