Biological monitoring of occupational exposure to polycyclic aromatic hydrocarbons (PAH) by determination of monohydroxylated metabolites of phenanthrene and pyrene in urine

International Archives of Occupational and Environmental Health

Volumn 81, Issue 2, 2007, Pages 221-229

  Rossbach, Bernd ^a   Preuss, Ralf ^b   Letzel, Stephan ^a   Drexler, Hans ^b   Angerer, Jürgen ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

1 Hydroxypyrene; Biological monitoring; Hydroxyphenanthrene; Polycyclic aromatic hydrocarbons; Urine

Indexed keywords

1 HYDROXYPYRENE; BENZO[A]PYRENE; CARCINOGEN; PHENANTHRENE; PHENANTHRENE DERIVATIVE; PHENANTHROL; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; UNCLASSIFIED DRUG;

ADULT; AIR SAMPLING; ARTICLE; BIOLOGICAL MONITORING; CHEMICAL INDUSTRY; COKING INDUSTRY; CORRELATION ANALYSIS; ELECTRONICS INDUSTRY; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; OCCUPATIONAL EXPOSURE; OCCUPATIONAL HEALTH; SMOKING; URINALYSIS; WORK ENVIRONMENT; WORKROOM AIR;

ADULT; AIR POLLUTANTS, OCCUPATIONAL; ENVIRONMENTAL MONITORING; GERMANY; HUMANS; MALE; MIDDLE AGED; MUTAGENS; OCCUPATIONAL EXPOSURE; PHENANTHRENES; POLYCYCLIC HYDROCARBONS, AROMATIC; PYRENES;

EID: 35448948419     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-007-0209-9     Document Type: Article

References (36)

1. Angerer J, Mannschreck C, Guendel J (1997a) Occupational exposure to polycyclic aromatic hydrocarbons in a graphite-electrode producing plant: Biological monitoring of 1-hydroxypyrene and monohydroxylated metabolites of phenanthrene. Int Arch Occup Environ Health 69:323-331
2. Angerer J, Mannschreck C, Guendel J (1997b) Biological monitoring and biochemical effect monitoring of exposure to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Health 70:365-377
3. Becker K, Schulz C, Kaus S, Seiwert M, Seifert B (2003) German Environmental Survey 1998 (GerES III): Environmental pollutants in the urine of the German population. Int J Hyg Environ Health 206:15-24
4. Bentsen-Farmen RK, Botnen IV, Noto H, Jacob J, Ovrebo S (1999) Detection of polycyclic aromatic hydrocarbon metabolites by high-pressure liquid chromatography after purification on immunoaffinity columns in urine from occupationally exposed workers. Int Arch Occup Environ Health 72:161-168
5. Bouchard M, Viau C (1999) Urinary 1-hydroxypyrene as a biomarker of exposure to polycyclic aromatic hydrocarbons: Biological monitoring strategies and methodology for determining biological exposure for various work environments. Biomarkers 4:159-187
6. DFG (2002) Deutsche Forschungsgemeinschaft, Angerer J. (Hrsg.): Biological monitoring. Prospects in occupational and environmental medicine. Wiley, Weinheim
7. DFG (2003) Deutsche Forschungsgemeinschaft, commission for the investigation of health hazards of chemical compounds in the work area (eds): List of MAK and BAT values. Report 39. Wiley, Weinheim
8. DFG (2004) Deutsche Forschungsgemeinschaft, Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe (Hrsg.): Polycyclische aromatische Kohlenwasserstoffe (PAH). Wiley, Weinheim
9. Goen T, Gundel J, Schaller KH, Angerer J (1995) The elimination of 1-hydroxypyrene in the urine of the general population and workers with different occupational exposures to PAH. Sci Total Environ 163:195-201
10. Grimmer G, Dettbarn G, Jacob J (1993) Biomonitoring of polycyclic aromatic hydrocarbons in highly exposed coke plant workers by measurement of urinary phenanthrene and pyrene metabolites (phenols and dihydrodiols). Int Arch Occup Environ Health 65:189-199
11. Guendel J, Mannschreck C, Buttner K, Ewers U, Angerer J (1996) Urinary levels of 1-hydroxypyrene, 1-, 2-, 3-, and 4-hydroxyphenanthrene in females living in an industrial area of Germany. Arch Environ Contam Toxicol 31:585-590
12. Guendel J, Schaller KH, Angerer J (2000) Occupational exposure to polycyclic aromatic hydrocarbons in a fireproof stone producing plant: biological monitoring of 1-hydroxypyrene, 1-, 2-, 3- and 4-hydroxyphenanthrene, 3-hydroxybenz(a)anthracene and 3-hydroxybenzo(a)pyrene. Int Arch Occup Environ Health 73:270-274
13. Heudorf U, Angerer J (2001a) Internal exposure to PAHs of children and adults living in homes with parquet flooring containing high levels of PAHs in the parquet glue. Int Arch Occup Environ Health 74:91-101
14. Heudorf U, Angerer J (2001b) Urinary monohydroxylated phenanthrenes and hydroxypyrene-the effects of smoking habits and changes induced by smoking on monooxygenase-mediated metabolism. Int Arch Occup Environ Health 74:177-183
15. IARC (1983) International Agency for Research on Cancer: Monographs on the evaluation of carcinogenic risks to humans: Polynuclear aromatic compunds. Part 1: Chemical, environmental and experimental data, vol 32. IARC, Lyon
16. IARC (1984) International Agency for Research on Cancer: Monographs on the evaluation of carcinogenic risks to humans: Polynuclear aromatic compunds. Part 3: Industrial exposures in aluminium production, coal gasification, coke production, and iron and steel founding, vol 34. IARC, Lyon
17. IARC (1985) International Agency for Research on Cancer: Monographs on the evaluation of carcinogenic risks to humans: Polynuclear aromatic compunds. Part 4: Bitumens, coal-tars and derived products, shale oils and soots, vol 35. IARC, Lyon
18. Jacob J, Grimmer G, Dettbarn G (1999) Profile of urinary phenanthrene metabolites in smokers and non-smokers. Biomarkers 4:319-327
19. Jongeneelen FJ, Anzion RB, Scheepers PT, Bos RP, Henderson PT, Nijenhuis EH, Veenstra SJ, Brouns RM, Winkes A (1988) 1-Hydroxypyrene in urine as a biological indicator of exposure to polycyclic aromatic hydrocarbons in several work environments. Ann Occup Hyg 32:35-43
20. Jongeneelen FJ, van Leeuwen FE, Oosterink S, Anzion RB, van der Loop F, Bos RP, van Veen HG (1990) Ambient and biological monitoring of cokeoven workers: Determinants of the internal dose of polycyclic aromatic hydrocarbons. Br J Ind Med 47:454-461
21. Kuusimaki L, Peltonen Y, Mutanen P, Peltonen K, Savela K (2004) Urinary hydroxy-metabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust. Int Arch Occup Environ Health 77:23-30
22. Lintelmann J, Angerer J (1999) PAH metabolites. In: Angerer J, Schaller KH (eds) Analysis of hazardous substances in biological materials, vol 6. Wiley, Weinheim, pp 163-187
23. Malkin R, Kiefer M, Tolos W (1996) 1-Hydroxypyrene levels in coal-handling workers at a coke oven. J Occup Environ Med 38:1141-1144
24. Marczynski B, Rihs HP, Rossbach B, Holzer J, Angerer J, Scherenberg M, Hoffmann G, Bruning T, Wilhelm M (2002) Analysis of 8-oxo-7,8-dihydro-2′-deoxyguanosine and DNA strand breaks in white blood cells of occupationally exposed workers: Comparison with ambient monitoring, urinary metabolites and enzyme polymorphisms. Carcinogenesis 23:273-281
25. NIOSH (1994) Polynuclear aromatic hydrocarbons by HPLC. In: Cassinelli ME, O'Conner PE (eds) NIOSH manual of analytical methods (NMAM), 4th edn. National Institute for Occupational Safety and Health, Washington
26. Popp W, Vahrenholz C, Schell C, Grimmer G, Dettbarn G, Kraus R, Brauksiepe A, Schmeling B, Gutzeit T, von Bulow J, Norpoth K (1997) DNA single strand breakage, DNA adducts, and sister chromatid exchange in lymphocytes and phenanthrene and pyrene metabolites in urine of coke oven workers. Occup Environ Med 54:176-183
27. Scherer G, Meger-Kossien I, Angerer J, Knecht U (2001) Cotinine. In: Angerer J, Schaller KH (eds) Analysis of hazardous substances in biological materials, vol 7. Wiley, Weinheim, pp 171-189
28. Seidel A, Dahmann D, Krekeler H, Jacob J (2002) Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust. Int J Hyg Environ Health 204:333-338
29. Serdar B, Waidyanatha S, Zheng Y, Rappaport SM (2003) Simultaneous determination of urinary 1- and 2-naphthols, 3- and 9-phenanthrols, and 1-pyrenol in coke oven workers. Biomarkers 8:93-109
30. Strunk P, Ortlepp K, Heinz H, Rossbach B, Angerer J (2002) Ambient and biological monitoring of coke plant workers-determination of exposure to polycyclic aromatic hydrocarbons. Int Arch Occup Environ Health 75:354-358
31. Taussky HH (1954) A microcolorimetric determination of creatine in urine by the Jaffe reaction. J Biol Chem 208:853-861
32. Vaananen V, Hameila M, Kontsas H, Peltonen K, Heikkila P (2003) Air concentrations and urinary metabolites of polycyclic aromatic hydrocarbons among paving and remixing workers. J Environ Monit 5:739-746
33. Van Rooij JG, Bodelier-Bade MM, Jongeneelen FJ (1993a) Estimation of individual dermal and respiratory uptake of polycyclic aromatic hydrocarbons in 12 coke oven workers. Br J Ind Med 50:623-632
34. Van Rooij JG, Van Lieshout EM, Bodelier-Bade MM, Jongeneelen FJ (1993b) Effect of the reduction of skin contamination on the internal dose of creosote workers exposed to polycyclic aromatic hydrocarbons. Scand J Work Environ Health 19:200-207
35. Van Schooten FJ, Jongeneelen FJ, Hillebrand MJ, van Leeuwen FE, de Looff AJ, Dijkmans AP, van Rooij JG, den Engelse L, Kriek E (1995) Polycyclic aromatic hydrocarbon-DNA adducts in white blood cell DNA and 1-hydroxypyrene in the urine from aluminium workers: Relation with job category and synergistic effect of smoking. Cancer Epidemiol Biomarkers Prev 4:69-77
36. WHO (1998) International Programme on Chemical Safety, Environmental Health Criteria: Selected non-heterocyclic polycyclic aromatic hydrocarbons, vol 202 WHO, Genf