Nitric oxide and GABA mediate bi-directional cardiovascular effects of orexin in the nucleus tractus solitarii of rats

Neuroscience

Volumn 149, Issue 3, 2007, Pages 625-635

  Shih, C D ^a   Chuang, Y C ^a  

^a TAJEN UNIVERSITY   (Taiwan)

Author keywords

GABA receptors; nitric oxide; nitric oxide synthase; nucleus tractus solitarii; orexin; systemic arterial pressure

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 1 (2 METHYLBENZOXAZOL 6 YL) 3 [1,5]NAPHTHYRIDIN 4 YL UREA; 1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; 2 HYDROXYSACLOFEN; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 7 NITROINDAZOLE; BICUCULLINE METHIODIDE; GLUTAMIC ACID; GUANYLATE CYCLASE INHIBITOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; OREXIN A; OREXIN B; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD VESSEL TONE; BRAIN; CARDIOVASCULAR AUTOREGULATION; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG MEGADOSE; HEART RATE; HEMODYNAMIC PARAMETERS; HISTOLOGY; LOW DRUG DOSE; MALE; MEAN ARTERIAL PRESSURE; MICROINJECTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS;

ANIMALS; BLOOD PRESSURE; BRAIN; CARDIOVASCULAR SYSTEM; GAMMA-AMINOBUTYRIC ACID; GUANYLATE CYCLASE; HEART RATE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; MUSCLE, SMOOTH, VASCULAR; NEUROPEPTIDES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SOLITARY NUCLEUS;

EID: 35448944868     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.07.016     Document Type: Article

References (49)

1. Ammoun S., Holmqvist T., Shariatmadari R., Oonk H.B., Detheux M., Parmentier M., Åkerman K.E.O., and Kukkonen J.P. Distinct recognition of OX1 and OX2 receptors by orexin peptides. J Pharmacol Exp Ther 305 (2003) 507-514
2. Arnold W.P., Mittal C.K., Katsuki S., and Murad F. Nitric oxide activates guanylate cyclase and increases guanosine 3′,5′-cyclic monophosphate levels in various tissue preparations. Proc Natl Acad Sci U S A 74 (1977) 3203-3207
3. Brown D.R., Brown L.V., Patwardhan A., and Randall D.C. Sympathetic activity and blood pressure are tightly coupled at 0.4 Hz in conscious rats. Am J Physiol 267 (1994) R1378-R1384
4. Chan J.Y.H., Chang A.Y.W., Wang L.L., Ou C.C., and Chan S.H.H. Protein kinase C-dependent mitochondrial translocation of proapoptotic protein Bax on activation of inducible nitric-oxide synthase in rostral ventrolateral medulla mediates cardiovascular depression during experimental endotoxemia. Mol Pharmacol 71 (2007) 1129-1139
5. Chan S.H.H., Wang L.L., and Chan J.Y.H. Differential engagements of glutamate and GABA receptors in cardiovascular actions of endogenous nNOS or iNOS at rostral ventrolateral medulla of rats. Br J Pharmacol 138 (2003) 584-593
6. Ciriello J. Brainstem projections of aortic baroreceptor afferent fibers in the rat. Neurosci Lett 36 (1983) 37-42
7. Cluderay J.E., Harrison D.C., and Hervieu G.J. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regul Pept 104 (2002) 131-144
8. Costa-e-Sousa R.H., Pereira-Junior P.P., Oliveira P.F., Olivares E.L., Werneck-de-Castro J.P.S., Mello D.B., Nascimento J.H.M., and Campos-de-Carvalho A.C. Cardiac effects of oxytocin: Is there a role for this peptide in cardiovascular homeostasis?. Regul Pept 132 (2005) 107-112
9. Date Y., Ueta Y., Yamashita H., Yamaguchi H., Matsukura S., Kangawa K., Sakurai T., Yanagisawa M., and Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A 96 (1999) 748-753
10. De Lecea L., Kilduff T.S., Peyron C., Gao X.B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett II F.S., Frankel W.N., van den Pol A.N., Bloom F.E., Gautvik K.M., and Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95 (1998) 322-327
11. de Oliveira C.V.R., Rosas-Arellano M.P., Solano-Flores L.P., and Ciriello J. Cardiovascular effects of hypocretin-1 in nucleus of the solitary tract. Am J Physiol 284 (2003) H1369-H1377
12. Garthwaite J., Southam E., Boulton C.L., Nielsen E.B., Schmidt K., and Mayer B. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-α]quinoxalin-1-one. Mol Pharmacol 48 (1995) 184-188
13. Geerling J.C., Mettenleiter T.C., and Loewy A.D. Orexin neurons project to diverse sympathetic outflow systems. Neuroscience 122 (2003) 541-550
14. Harada S., Tokunaga S., Momohara M., Masaki H., Tagawa T., Imaizumi T., and Takeshita A. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ Res 72 (1993) 511-516
15. Hirota K., Kushikata T., Kudo M., Kudo T., Smart D., and Matsuki A. Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats. Brain Res 981 (2003) 143-150
16. Kajiyama S., Kawamoto M., Shiraishi S., Gaus S., Matsunaga A., Suyama H., and Yuge O. Spinal orexin-1 receptors mediate anti-hyperalgesic effects of intrathecally-administered orexins in diabetic neuropathic pain model rats. Brain Res 1044 (2005) 76-86
17. Kayaba Y., Nakamura A., Kasuya Y., Ohuchi T., Yanagisawa M., Komuro I., Fukuda Y., and Kuwaki T. Attenuated defense response and low basal blood pressure in orexin knockout mice. Am J Physiol 285 (2003) R581-R593
18. Korotkova T.M., Eriksson K.S., Haas H.L., and Brown R.E. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regul Pept 104 (2002) 83-89
19. Kubo T., and Kihara M. Evidence for gamma-aminobutyric acid receptor-mediated modulation of the aortic baroreceptor reflex in the nucleus tractus solitarii of the rat. Neurosci Lett 89 (1988) 156-160
20. Kukkonen J.P., Holmqvist T., Ammoun S., and Åkerman K.E.O. Functions of the orexinergic/hypocretinergic system. Am J Physiol 283 (2002) C1567-C1591
21. Kuo T.B.J., and Chan S.H.H. Continuous, on-line, real-time spectral analysis of systemic arterial pressure signals. Am J Physiol 264 (1993) H2208-H2213
22. Kuo T.B.J., Yang C.C.H., and Chan S.H.H. Selective activation of vasomotor component of SAP spectrum by nucleus reticularis ventrolateralis in rats. Am J Physiol 272 (1997) H485-H492
23. Le Galloudec E., Merahi N., and Laguzzi R. Cardiovascular changes induced by the local application of glutamate-related drugs in the rat nucleus tractus solitarii. Brain Res 503 (1989) 322-325
24. Lin H.C., Wan F.J., and Tseng C.J. Modulation of cardiovascular effects produced by nitric oxide and ionotropic glutamate receptor interaction in the nucleus tractus solitarii of rats. Neuropharmacology 38 (1999) 935-941
25. Lin L.H., Cassell M.D., Sandra A., and Talman W.T. Direct evidence for nitric oxide synthase in vagal afferents to the nucleus tractus solitarii. Neuroscience 84 (1998) 549-558
26. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., and Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435 (2001) 6-25
27. Matsumura K., Tsuchihashi T., and Abe I. Central orexin-A augments sympathoadrenal outflow in conscious rabbits. Hypertension 37 (2001) 1382-1387
28. Ohta A., Takagi H., Matsui T., Hamai Y., Iida S., and Esumi H. Localization of nitric oxide synthase-immunoreactive neurons in the solitary nucleus and ventrolateral medulla oblongata of the rat: their relation to catecholaminergic neurons. Neurosci Lett 158 (1993) 33-35
29. Padda G.S., Kishioka C., and Rubin B.K. Propofol and methohexital have no significant effect on mucus secretion or clearance in the anesthetized dog. Crit Care Med 29 (2001) 1045-1048
30. Peyron C., Tighe D.K., van den Pol A.N., de Lecea L., Heller H.C., Sutcliffe J.G., and Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18 (1998) 9996-10015
31. Prast H., Tran M.H., Fischer H., and Philippu A. Nitric oxide-induced release of acetylcholine in the nucleus accumbens: role of cyclic GMP, glutamate, and GABA. J Neurochem 71 (1998) 266-273
32. Rubini R., Porta A., Baselli G., Cerutti S., and Paro M. Power spectrum analysis of cardiovascular variability monitored by telemetry in conscious unrestrained rats. J Auton Nerv Syst 45 (1993) 181-190
33. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., and Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92 (1998) 573-585
34. Shih C.D., Au L.C., and Chan J.Y.H. Differential role of leptin receptors at the hypothalamic paraventricular nucleus in tonic regulation of food intake and cardiovascular functions. J Biomed Sci 10 (2003) 367-378
35. Shih C.D., Chan S.H.H., and Chan J.Y.H. Participation of Fos protein at the nucleus tractus solitarius in inhibitory modulation of baroreceptor reflex response in the rat. Brain Res 738 (1996) 39-47
36. Shirasaka T., Nakazato M., Matsukura S., Takasaki M., and Kannan H. Sympathetic and cardiovascular actions of orexins in conscious rats. Am J Physiol 277 (1999) R1780-R1785
37. Smith P.M., Connolly B.C., and Ferguson A.V. Microinjection of orexin into rat nucleus tractus solitarius causes increases in blood pressure. Brain Res 950 (2002) 261-267
38. Sunter D., Morgan I., Edwards C.M.B., Dakin C.L., Murphy K.G., Gardiner J., Taheri S., Rayes E., and Bloom S.R. Orexins: effects on behavior and localisation of orexin receptor 2 messenger ribonucleic acid in the rat brainstem. Brain Res 907 (2001) 27-34
39. Sutcliffe J.G., and de Lecea L. The hypocretins: setting the arousal threshold. Nat Rev Neurosci 3 (2002) 339-349
40. B receptors in the nucleus tractus solitarius to increase blood pressure. Brain Res 526 (1990) 235-240
41. Szabo C., Southan G.J., and Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci U S A 91 (1994) 12472-12476
42. Tseng C.J., Liu H.Y., Lin H.C., Ger L.P., Tung C.S., and Yen M.H. Cardiovascular effects of nitric oxide in the brain stem nuclei of rats. Hypertension 27 (1996) 36-42
43. Viggiano A.N., Monda M., Viggiano A., Fuccio F., and De Luca B. Extracellular GABA in the medial hypothalamus is increased following hypocretin-1 administration. Acta Physiol Scand 182 (2004) 89-94
44. Wang L.L., Ou C.C., and Chan J.Y.H. Receptor-independent activation of GABAergic neurotransmission and receptor-dependent nontranscriptional activation of phosphatidylinositol 3-kinase/protein kinase Akt pathway in short-term cardiovascular actions of dexamethasone at the nucleus tractus solitarii of the rat. Mol Pharmacol 67 (2005) 489-498
45. Wang S., Paton J.F.R., and Kasparov S. Differential sensitivity of excitatory and inhibitory synaptic transmission to modulation by nitric oxide in rat nucleus tractus solitarii. Exp Physiol 92 (2007) 371-382
46. Wang S., Teschemacher A.G., Paton J.F.R., and Kasparov S. Mechanism of nitric oxide action on inhibitory GABAergic signaling within the nucleus tractus solitarii. FASEB J 20 (2006) E821-E831
47. Wu R.S.C., Wu K.C., Sum D.C.W., and Bishop M.J. Comparative effects of thiopentone and propofol on respiratory resistance after tracheal intubation. Br J Anaesth 77 (1996) 735-738
48. Yang C.H., Shyr M.H., Kuo T.B.J., Tan P.P.C., and Chan S.H.H. Effects of propofol on nociceptive response and power spectra of electroencephalographic and systemic arterial pressure signals in the rat: correlation with plasma concentration. J Pharmacol Exp Ther 275 (1995) 1568-1574
49. Zheng H., Patterson L.M., and Berthoud H.R. Orexin-A projections to the caudal medulla and orexin-induced c-fos expression, food intake, and autonomic function. J Comp Neurol 485 (2005) 127-142