Assessing the palatability of medications in children

Paediatric and Perinatal Drug Therapy

Volumn 8, Issue 2, 2007, Pages 55-60

  Matsui, Doreen ^a,b  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

^b CHILDREN S HOSPITAL OF WESTERN ONTARIO   (Canada)

Author keywords

Antibiotic; Children; Medication; Palatability; Taste

Indexed keywords

ACTIVATED CARBON; AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; ANTIBIOTIC AGENT; AZITHROMYCIN; BACAMPICILLIN; CEFDINIR; CEFIXIME; CEFPODOXIME; CEFPROZIL; CLARITHROMYCIN; CLINDAMYCIN; CLOXACILLIN; FLAVORING AGENT; LANSOPRAZOLE; LORACARBEF; ONDANSETRON; PENICILLIN G; PIVAMPICILLIN; PREDNISOLONE; RANITIDINE;

ASTHMA; CORRELATION ANALYSIS; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG MANUFACTURE; DRUG PREFERENCE; DRUG SAFETY; HUMAN; INFECTION; LIQUID; PALATABILITY; PATIENT COMPLIANCE; PRESCRIPTION; REVIEW; SUSPENSION; TASTE; TASTE ACUITY; TASTE DISCRIMINATION; TASTE PREFERENCE; VERBAL BEHAVIOR; VISUAL ANALOG SCALE;

EID: 35448942608     PISSN: 14630095     EISSN: None     Source Type: Journal    
DOI: 10.1185/146300907X178941     Document Type: Review

References (52)

1. Compact Oxford English Dictionary. http://www. askoxford.com/ dictionaries/?view=uk. Accessed April 9, 2007.
2. Llorens J. The physiology of taste and smell: how and why we sense flavors. Water Sci Technol 2004; 49:1-10.
3. Lawless H. Sensory development in children: research in taste and olfaction. J Am Diet Assoc 1985; 85:577-582.
4. Pawar S, Kumar A. Issues in the formulation of drugs for oral use in children. Pediatr Drugs 2002; 4:371-379.
5. Leathwood P, Maier A. Early influences on taste preferences. Nestle Nutr Workshop Ser Pediatr Program 2005;56:127-141.
6. Rosenstein D, Oster H. Differential facial responses to four basic tastes in newborns. Child Dev 1988; 59:1555-1568.
7. Liem DG, Mennella JA. Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol 2002;41:388-395.
8. Mennella JA, Pepino Y, Reed DR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005;115:e216-e222.
9. Rodgers GC. The role of aversive bittering agents in the prevention of pediatric poisonings. Pediatrics 1994;93:68-69.
10. Bagger-Sjoback D, Bondesson G. Taste evaluation and compliance of two paediatric formulations of phenoxymethylpenicillin in children. Scand J Prim Health Care 1989;7:87-92.
11. Demers DM, Schotik Chan D, Bass JW. Antimicrobial drug suspensions: a blinded comparison of taste of twelve common pediatric drugs including cefixime, cefpodoxime, cefprozil and loracarbef. Pediatr Infect Dis J 1994;13:87-89.
12. Powers J. Properties of azithromycin that enhance the potential for compliance in children with upper respiratory tract infections. Pediatr Infect Dis J 1996;15:30-37.
13. El-Chaar GM, Mardy G, Wehlou K, Rubin L. Randomized, double blind comparison of brand and generic antibiotic suspensions: II. A study of taste and compliance in children. Pediatr Infect Dis J 1996;15:18-22.
14. Nahata MC. Lack of pediatric drug formulations. Pediatrics 1999;104:607-609.
15. Steele RW, Thomas MP, Begue RE, Despinasse BP. Section of pediatric antibiotic suspensions: taste and cost factors. Infect Med 1999; 16:197-200.
16. Powers JL, Gooch WM, Oddo LP. Comparison of the palatability of the oral suspension of cefdinir vs. amoxicillin/clavulanate potassium, cefprozil and azithromycin in pediatric patients. Pediatr Infect Dis J 2000;19:S174-S180.
17. Steele RW, Thomas MP, Begue RE. Compliance issues related to the selection of antibiotic suspensions for children. Pediatr Infect Dis J 2001; 20:1-5.
18. Ramgoolarn A, Steele R. Formulations of antibiotics for children in primary care - effects on compliance and efficacy. Pediatr Drugs 2002;4:323-333.
19. Hendeles L. Selecting a systemic corticosteroid for acute asthma in young children. J Pediatr 2003; 142:S40-S44.
20. Standing JF, Tuleu C. Paediatric formulations - getting to the heart of the problem. Int J Pharm 2005;300:56-66.
21. Toscani M, Drehobl M, Freed J, Stool S. A multi-center, randomized, comparative assessment in healthy pediatric volunteers of the palatability of oral antibiotics effective in the therapy of otitis media. Curr Ther Res Clin Exp 2000;61:278-285.
22. Pichichero ME. Evaluating the need, timing and best choice of antibiotic therapy for acute otitis media and tonsillopharyngitis infections in children. Pediatr Infect Dis J 2000;19:S131-S140.
23. Hutto CJ, Bratton TH. Palatability and cost comparison of five liquid corticosteroid formulations. J Pediatr Oncol Nurs 1999;16: 74-77.
24. Goode M, McMaugh A, Crisp J, Wales S, Ziegler JB. Adherence issues in children and adolescents receiving highly active antiretroviral therapy. AIDS CARE 2003;15:403-408.
25. Reddington C, Cohen J, Baldillo et al. Adherence to medication regimens among children with human immunodeficiency virus infection. Pediatr Infect Dis J 2000;19:1148-1153.
26. Lucus-Bouwman ME, Roorda RJ, Jansman FGA, Brand PLP. Crushed prednisolone tablets or oral solution for acute asthma? Arch Dis Child 2001; 84:347-348.
27. Reflection paper: formulations of choice for the paediatric population, http://www.emea.europa. eu/pdfs/human/peg/19481005en.pdf. Accessed April 9, 2007.
28. Steele RW, Russo TM, Thomas MP. Adherence issues related to the selection of antistaphylococcal or antifungal antibiotic suspensions for children. Clin Pediatr 2006;45:245-250.
29. Sohi H, Sultana Y, Khar RK. Taste masking technologies in oral pharmaceuticals: recent developments and approaches. Drug Dev Ind Pharm 2004;30:429-448.
30. Barra J, Lescure F, Doelker E. Taste masking as a consequence of the organization of powder mixes. Pharm Acta Helv 1999;74:37-42.
31. Nunn T, Williams J. Formulation of medicines for children. Br J Clin Pharmacol 2005;59:674-676.
32. Tolia V, Johnston G, Stolle J, Lee C. Flavor and taste of lansoprazole strawberry-flavored delayed-release oral suspension preferred over ranitidine peppermint-flavored oral syrup in children aged between 5-11 years. Pediatr Drugs 2004; 6:127-131.
33. Matsui D, Barron A, Rieder MJ. Assessment of the palatability of antistaphylococcal antibiotics in pediatric volunteers. Ann Pharmacother 1996; 30:586-588.
34. Pronchik D, Kasper L, Chambers J. Can parents predict a child's taste in antibiotics? Pediatr Emerg Care 1999;15:371.
35. Wheeler Chater R. Pediatric dosing: tips for tots. Am Pharm 1993;NS33:55-56.
36. Cabaleiro J. Flavoring meds for children and adults. Home Healthc Nurs 2003;21:295-298.
37. Anbar RD. You don't like the taste of your medication? So change the taste! Clin Pediatr 2002;41:197-198.
38. Matsui D, Lim R, Tschen T, Rieder MJ. Assessment of the palatability of β-lactamase-resistant antibiotics in children. Arch Pediatr Adolesc Med 1997; 151:599-602.
39. Dagan R, Shvartzman P, Liss Z. Variation in acceptance of common oral antibiotic suspensions. Pediatr Infect Dis J 1994;13:686-690.
40. Marshall J, Rodarte A, Blumer J et al. Pediatric pharmacodynamics of midazolam oral syrup. J Clin Pharmacol 2000;40:578-89.
41. Uhari M, Eskelinen L, Jokisalo J. Acceptance of antibiotic mixtures by infants and children. Eur J Clin Pharmacol 1986;30:503-504.
42. Sjovall J, Fogh A, Huitfeldt B, Karlsson G, Nylen O. Methods for evaluating the taste of paediatric formulations in children: a comparison between the facial hedonic method and the patients' own spontaneous verbal judgement. Eur J Pediatr 1984; 141:243-247.
43. Jahnsen T, Thorn P. An acceptability study of two pivampicillin mixtures in children in general practice. Scand J Prim Health Care 1987;5: 241-243.
44. Angelilli ML, Toscani M, Matsui DM, Rieder MJ. Palatability of oral antibiotics among children in an urban primary care center. Arch Pediatr Adolesc Med 2000;154:267-270.
45. Holas C, Chiu Y, Notario G, Kapral D. A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years. Clin Ther 2005;27:1950-1960.
46. Stevens R, Votan B, Lane R, Schaison G. A randomized study of ondansetron syrup in children: evaluation of taste acceptability and tolerance. Pediatr Hematol Oncol 1996;13: 199-202.
47. Guenther Skokan E, Junkins EP, Corneli HM, Schunk JE. Taste test - children rate flavoring agents used with activated charcoal. Arch Pediatr Adolesc Med 2001;155:683-686.
48. Dagnone D, Matsui D, Rieder MJ. Assessment of the palatability of vehicles for activated charcoal in pediatric volunteers. Pediatr Emerg Care 2002; 18:19-21.
49. Ameen VZ, Pobiner BF, Giguere GC, Carter EG. Ranitidine (Zantac®) syrup versus ranitidine effervescent tablets (Zantac® EFFERdose®) in children - a single-center taste preference study. Pediatr Drugs 2006;8:265-270.
50. Kim MK, Yen K, Redman RL. Vomiting of liquid corticosteroids in children with asthma. Pediatr Emerg Care 2006:22:397-401.
51. Skolin I, Wahlin YB, Broman DA. Altered food intake and taste perception in children with cancer after start of chemotherapy: perspectives of children, parents and nurses. Support Care Cancer 2006;14:369-378.
52. Ishizaka T, Miyanaga Y, Mukai J et al. Bitterness evaluation of medicines for pediatric use by a taste sensor. Chem Pharm Bull 2004;52:943-948.