Toxicogenomics of drug-induced hemolytic anemia by analyzing gene expression profiles in the spleen

Toxicological Sciences

Volumn 100, Issue 1, 2007, Pages 290-302

  Rokushima, Masatomo ^a   Omi, Kazuo ^a   Imura, Kae ^a   Araki, Akiko ^a   Furukawa, Naoko ^a   Itoh, Fumio ^a   Miyazaki, Masako ^a   Yamamoto, Junko ^a   Rokushima, Makiko ^a   Okada, Manabu ^a   Torii, Mikinori ^a   Kato, Ikuo ^a   Ishizaki, Jun ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Biomarker; Hemolytic anemia; Spleen; Toxicogenomics

Indexed keywords

HEME OXYGENASE 1; PHENACETIN; PHENYLHYDRAZINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MARKER; DRUG INDUCED DISEASE; ERYTHROCYTE COUNT; FEMALE; GENE CLUSTER; GENE EXPRESSION PROFILING; GENETIC ANALYSIS; GENETIC TOXICOLOGY; GENETIC TRANSCRIPTION; HEMOLYTIC ANEMIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTERMETHOD COMPARISON; IRON METABOLISM; MICROARRAY ANALYSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SPLEEN; UPREGULATION;

ANEMIA, HEMOLYTIC; ANIMALS; BIOMARKERS, PHARMACOLOGICAL; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; HEME OXYGENASE (DECYCLIZING); IMMUNOHISTOCHEMISTRY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENACETIN; PHENYLHYDRAZINES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; SPLEEN; TOXICOGENETICS;

RATTUS;

EID: 35448940972     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm216     Document Type: Article

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