Modulation of a spinal locomotor network by metabotropic glutamate receptors

European Journal of Neuroscience

Volumn 26, Issue 8, 2007, Pages 2257-2268

  Chapman, Rebecca J ^a,b   Sillar, Keith T ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Neuromodulation; Spinal cord; Vertebrate; Xenopus laevis

Indexed keywords

(2,4)AMINOPYRROLIDINE 2,4 DICARBOXYLIC ACID; 1 ETHYL 2 BENZIMIDAZOLINONE; 2 AMINO 2 METHYL 4 PHOSPHONOBUTYRIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2 METHYL 6 (PHENYLETHYNYL)PYRIDINE; 3,5 DIHYDROXYPHENYLGLYCINE; DICARBOXYLIC ACID DERIVATIVE; METABOTROPIC RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; ENZYME ACTIVATION; LARVA; LOCOMOTION; MOTOR ACTIVITY; NERVE CELL NETWORK; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SWIMMING; TADPOLE; VENTRAL ROOT; XENOPUS LAEVIS;

ACTION POTENTIALS; AMINOBUTYRIC ACIDS; ANIMALS; BEHAVIOR, ANIMAL; CHROMONES; EMBRYO, NONMAMMALIAN; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATES; LARVA; LOCOMOTION; METHOXYHYDROXYPHENYLGLYCOL; NERVE NET; PERIODICITY; PHYSICAL STIMULATION; RECEPTORS, METABOTROPIC GLUTAMATE; SPINAL CORD; SWIMMING; TIME FACTORS; XENOPUS LAEVIS;

EID: 35448937231     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05817.x     Document Type: Article

References (49)

1. Cartmell, J. Schoepp, D.D. (2000) Regulation of neurotransmitter release by metabotropic glutamate receptors. J. Neurochem., 75, 889 907.
2. Cochilla, A.J. Alford, S. (1998) Metabotropic glutamate receptor-mediated control of neurotransmitter release. Neuron, 20, 1007 1016.
3. Dale, N., Ottersen, O.P., Roberts, A. Storm-Mathisen, J. (1986) Inhibitory neurones of a motor pattern generator in Xenopus revealed by antibodies to glycine. Nature, 324, 255 257.
4. Dale, N. Roberts, A. (1984) Excitatory amino acid receptors in Xenopus embryo spinal cord and their role in the activation of swimming. J. Physiol., 348, 527 543.
5. Dale, N. Roberts, A. (1985) Dual-component amino-acid-mediated synaptic potentials: excitatory drive for swimming in Xenopus embryos. J. Physiol., 363, 35 59.
6. Delgado-Lezama, R., Perrier, J.F., Nedergaard, S., Svirskis, G. Hounsgaard, J. (1997) Metabotropic synaptic regulation of intrinsic response properties of turtle spinal motorneurons. J. Physiol., 504, 97 102.
7. El Manira, A., Kettunen, P., Hess, D. Kreiger, P. (2002) Metabotropic glutamate receptors provide intrinsic modulation of the lamprey locomotor network. Brain Res. Rev., 40, 9 18.
8. Holohean, A.M., Hackman, J.C. Davidoff, R.A. (1999) Mechanisms involved in the metabotropic glutamate receptor-enhancement of NMDA-mediated motoneurone responses in frog spinal cord. Br. J. Pharmacol., 126, 333 341.
9. 5, mediates depolarization of spinal cord neurons by blocking a leak current. J. Neurophysiol., 90, 2341 2348.
10. Kettunen, P., Krieger, P., Hess, D. El Manira, A. (2002) Signalling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in locomotor network. J. Neurosci., 22, 1868 1873.
11. Kettunen, P., Kyriakatos, A., Hallen, K. El Manira, A. (2005) Neuromodulation via conditional release of endocannabinoids in the spinal locomotor network. Neuron, 45, 95 104.
12. Kozhanov, V.M., Karamian, O.A., Chmykhova, N.M. Clamann, H.P. (2001) Modulation of the spontaneous synaptic activity of tortoise spinal motorneurons by group II metabotropic glutamate receptors. Neurophysiology, 33, 98 105.
13. Krieger, P., El Manira, A. Grillner, S. (1996) Activation of pharmacologically distinct metabotropic glutamate receptors depresses reticulospinal-evoked monosynaptic EPSPs in the Lamprey spinal cord. J. Neurophysiol., 76, 3834 3841.
14. Krieger, P., Grillner, S. El Manira, A.J. (1998) Endogenous activation of metabotropic glutamate receptors contributes to burst frequency regulation in the lamprey locomotor network. Eur. J. Neurosci., 10, 3333 3342.
15. Krieger, P., Hellgren-Kotaleski, J., Kettuen, P. El Manira, A.J. (2000) Interaction between metabotropic and ionotropic glutamate receptors regulates neuronal network activity. J. Neurosci., 20, 5382 5391.
16. Li, W.C., Perrins, R., Soffe, S.R., Yoshida, M., Walford, A. Roberts, A. (2001) Defining classes of spinal interneuron and their axonal projections in hatchling Xenopus laevis tadpoles. J. Comp. Neurol., 441, 248 265.
17. Li, W.C., Soffe, S.R. Roberts, A. (2004) Glutamate and acetylcholine corelease at developing synapses. Proc. Natl Acad. Sci. USA, 101, 15488 15493.
18. 5, relative to neurotransmitter release sites. J. Chem. Neuroanat., 13, 219 241.
19. Marchetti, C., Taccola, G. Nistri, A. (2003) Distinct subtypes of group I metabotropic glutamate receptors on rat spinal neurons mediate complex facilitatory and inhibitory effects. Eur. J. Neurosci., 18, 1873 1883.
20. McDearmid, J., Scrymgeour-Wedderburn, J.F.S. Sillar, K.T. (1997) Aminergic modulation of glycine release in a spinal network controlling swimming in Xenopus laevis. J. Physiol., 503, 1473 1482.
21. McLean, D.L., McDearmid, J.R. Sillar, K.T. (2001) Induction of a non-rhythmic motor pattern by nitric oxide in hatchling Rana temporaria embryos. J. Exp. Biol., 204, 1307 1317.
22. McLean, D.L. Sillar, K.T. (2000) The distribution of NADPH-diaphorase- labelled interneurons and the role of nitric oxide in the swimming system of Xenopus laevis larvae. J. Exp. Biol., 203, 705 713.
23. Merrywest, S.D., Fischer, H. Sillar, K.T. (2002) Alpha-adrenoreceptor activation modulates swimming via glycinergic and GABAergic inhibitory pathways in Xenopus laevis tadpoles. Eur. J. Neurosci., 15, 375 383.
24. 1 antagonist. J. Pharmacol. Exptl. Ther., 281, 721 729.
25. Nieuwkoop, P.D. Faber, J. (1956) Normal Tables of Xenopus laevis (Daudin). North Holland, Amsterdam.
26. O'Neill, F.M., Heron-Maxwell, C., Conway, M.W., Monn, J.A. Ornstien, P. (2003) Group II metabotropic glutamate receptor antagonists LY341495 and LY366457 increase locomotor activity in mice. Neuropharmacology, 45, 565 574.
27. Perrins, R. Roberts, A. (1995a) Cholinergic and electrical motoneuron-to-motoneuron synapses contribute to on-cycle excitation during swimming in Xenopus embryos. J. Neurophysiol., 73, 1005 1012.
28. Perrins, R. Roberts, A. (1995b) Cholinergic contribution to excitation in a spinal locomotor central pattern generator in Xenopus embryos. J. Neurophysiol., 73, 1013 1019.
29. 3, show unique postsynaptic, presynaptic and glial localizations. Neuroscience, 71, 949 976.
30. Reith, C.A. Sillar, K.T. (1997) Pre- and postsynaptic modulation of spinal GABAergic neurotransmission by the neurosteroid, 5beta-pregnan-3alpha-ol- 20-one. Brain Res., 770, 202 212.
31. Roberts, A. (1989) A mechanism for switching in the nervous system: turning ON swimming in a frog tadpole. In Durbin, R., Mial, C. Mitchson, G. (Eds), The Computing Neurone. Addison-Wesley, Wokingham, pp. 229 243.
32. Roberts, A. Clarke, J.D.W. (1982) The neuroanatomy of an amphibian embryo spinal cord. Phil. Trans. R. Soc. Lond. B, 296, 195 212.
33. Roberts, R., Soffe, S.R., Wolf, E.S., Yoshida, M. Zhao, F.-Y. (1998) Central circuits controlling locomotion in young frog tadpoles. Ann. NY Acad. Sci., 860, 18 34.
34. Russo, R.E., Nagy, F. Hounsgaard, J. (1997) Modulation of plateau properties in dorsal horn neurones in slice preparation of the turtle spinal cord. J. Physiol., 499, 459 454.
35. Schoepp, D.D., Jane, D.E. Monn, J.A. (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology, 38, 1431 1476.
36. Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M., Flor, P.J., Neki, A., Abe, T., Shigetada, N. Mizuno, N. (1997) Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J. Neurosci., 17, 7503 7522.
37. Sillar, K.T., Fischer, H., McLean, D.L. Merrywest, S.D. (2002) Fast inhibitory synapses: targets for neuromodulation and development of vertebrate motor behaviour. Brain Res. Rev., 40, 130 140.
38. Sillar, K.T., Reith, C.A. McDearmid, J.R. (1998) Development and aminergic neuromodulation of a spinal locomotor network controlling swimming in Xenopus larvae. Ann. NY Acad. Sci., 860, 318 332.
39. Sillar, K.T. Roberts, A. (1988) Unmyelinated cutaneous afferent neurons activate two types of excitatory amino acid receptor in the spinal cord of Xenopus laevis embryos. J. Neurosci., 8, 1350 1360.
40. Sillar, K.T. Roberts, A. (1993) Control of frequency during swimming in Xenopus embryos: a study on interneuronal recruitment in a spinal rhythm generator. J. Physiol., 472, 557 572.
41. Sillar, K.T., Wedderburn, J.F.S. Simmers, A.J. (1991) The development of swimming rhythmicity in post-embryonic Xenopus laevis. Proc. R. Soc. Lond. B, 246, 147 153.
42. Soffe, S.R. (1987) Ionic and pharmacological properties of reciprocal inhibition in Xenopus embryo motorneurons. J. Physiol., 382, 463 473.
43. Soffe, S.R. (1993) Two distinct rhythmic motor patterns are driven by common premotor and motorneurons in a simple vertebrate spinal cord. J. Neuosci., 13, 4456 4469.
44. Svirskis, D. Hounsgaard, J. (1998) Transmitter regulation of plateau properties in turtle motoneurons. J. Neurophysiol., 79, 45 50.
45. Taccola, G., Marchetti, C. Nistri, A. (2003) Effect of metabotropic glutamate receptor activity on rhythmic discharges of the neonatal rat spinal cord in vitro. Exp. Brain Res., 153, 388 393.
46. Taccola, G., Marchetti, C. Nistri, A. (2004a) Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. Eur. J. Neurosci., 19, 533 541.
47. Taccola, G., Marchetti, C. Nistri, A. (2004b) Role of group II and III metabotropic glutamate receptors in rhythmic patterns of the neonatal rat spinal cord in vitro. Exp. Brain Res., 156, 495 504.
48. Tunstall, M.J. Sillar, K.T. (1993) Physiological and developmental aspects of intersegmental coordination in Xenopus embryos and tadpoles. The Neurosciences, 5, 29 40.
49. Zhao, F.Y. Roberts, A. (1998) Assessing the roles of glutamatergic and cholinergic synaptic drive in the control of fictive swimming frequency in young Xenopus tadpoles. J. Comp. Physiol. A, 183, 753 758.