Gastric bypass alters the dynamics and metabolic effects of insulin and proinsulin secretion

Diabetic Medicine

Volumn 24, Issue 11, 2007, Pages 1213-1220

  Johansson, H E ^a,b   Ohrvall M ^a   Haenni, A ^a   Sundbom, M ^a   Eden Engstrom B ^a   Karlsson, F A ^a   Zethelius, B ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

Gastric by pass; Insulin; Obesity; Proinsulin

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LIPID; PROINSULIN; TRIACYLGLYCEROL;

ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; BODY WEIGHT; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; INSULIN METABOLISM; INSULIN RELEASE; MALE; MOLECULAR DYNAMICS; MORBID OBESITY; POSTPRANDIAL STATE; STOMACH BYPASS; WEIGHT REDUCTION;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; FOLLOW-UP STUDIES; GASTRIC BYPASS; HUMANS; INSULIN; MALE; OBESITY; POSTPRANDIAL PERIOD; PROINSULIN;

EID: 35448933743     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2007.02240.x     Document Type: Article

References (35)

1. DeFronzo RA, Ferrannini E. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991 14 : 173 194.
2. Bonadonna RC, Groop L, Kraemer N, Ferrannini E, Del Prato S, DeFronzo RA. Obesity and insulin resistance in humans: a dose-response study. Metabolism 1990 39 : 452 459.
3. Drake AJ, Greenhalgh L, Newbury-Ecob R, Crowne EC, Shield JP. Pancreatic dysfunction in severe obesity. Arch Dis Child 1990 84 : 261 262.
4. Haffner SM, Stern MP, Hazuda HP, Pugh JA, Patterson JK. Hyperinsulinemia in a population at high risk for non-insulin-dependent diabetes mellitus. N Engl J Med 1986 315 : 220 224.
5. Hanley AJ, D'Agostino R Jr., Wagenknecht LE, Saad MF, Savage PJ, Bergman R, Haffner SM. Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study. Diabetes 2002 51 : 1263 1270.
6. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C. Proinsulin and acute insulin response independently predict Type 2 diabetes mellitus in men - report from 27 years of follow-up study. Diabetologia 2003 46 : 20 26.
7. Schulze MB, Solomon CG, Rifai N, Cohen RM, Sparrow J, Hu FB, Manson JE. Hyperproinsulinaemia and risk of Type 2 diabetes mellitus in women. Diabet Med 2005 22 : 1178 1184.
8. Zethelius B, Lithell H, Hales CN, Berne C, Dunder K, Lind L et al. Insulin sensitivity, proinsulin and insulin as predictors of coronary heart disease. A population-based 10-year, follow-up study in 70-year old men using the euglycaemic insulin clamp. Diabetologia 2005 48 : 862 867.
9. Yudkin JS, May M, Elwood P, Yarnell JW, Greenwood R, Davey Smith G. Concentrations of proinsulin like molecules predict coronary heart disease risk independently of insulin: prospective data from the Caerphilly Study. Diabetologia 2002 45 : 327 336.
10. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C. Proinsulin is an independent predictor of coronary heart disease: report from a 27-year follow-up study. Circulation 2002 105 : 2153 2158.
11. Jones CN, Abbasi F, Carantoni M, Polonsky KS, Reaven GM. Roles of insulin resistance and obesity in regulation of plasma insulin concentrations. Am J Physiol Endocrinol Metab 2000 278 : E501 508.
12. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002 346 : 393 403.
13. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001 344 : 1343 1350.
14. Muscelli E, Mingrone G, Camastra S, Manco M, Pereira JA, Pareja JC, Ferrannini E. Differential effect of weight loss on insulin resistance in surgically treated obese patients. Am J Med 2005 118 : 51 57.
15. Pereira JA, Lazarin MA, Pareja JC, de Souza A, Muscelli E. Insulin resistance in nondiabetic morbidly obese patients: effect of bariatric surgery. Obes Res 2003 11 : 1495 1501.
16. Kellum JM, Kuemmerle JF, O'Dorisio TM, Rayford P, Martin D, Engle K et al. Gastrointestinal hormone responses to meals before and after gastric bypass and vertical banded gastroplasty. Ann Surg 1990 211 : 763 770 discussion 770 761.
17. Sjostrom L, Lindroos AK, Peltonen M, Torgerson J, Bouchard C, Carlsson B et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004 351 : 2683 2693.
18. Sundbom M, Gustavsson S. Bariatric surgery. Clin Dermatol 2004 22 : 325 331.
19. Sjostrom CD. Surgery as an intervention for obesity. Results from the Swedish obese subjects study. Growth Horm IGF Res 2003 13 : S22 26.
20. le Roux CW. Gut hormone profiles following bariatric surgery favor an anoretic state, facilitate weigth loss, and improve metabolic parameters. Ann Surg 2006 243 : 108 114.
21. Ram E, Vishne T, Maayan R, Lerner I, Weizman A, Dreznik Z et al. The relationship between BMI, plasma leptin, insulin and proinsulin before and after laparoscopic adjustable gastric banding. Obes Surg 2005 15 : 1456 1462.
22. Meryn S, Stein D, Straus EW. Fasting- and meal-stimulated peptide hormone concentrations before and after gastric surgery for morbid obesity. Metabolism 1986 35 : 798 802.
23. Reaven GM, Chen YD, Hollenbeck CB, Sheu WH, Ostrega D, Polonsky KS. Plasma insulin, C-peptide, and proinsulin concentrations in obese and nonobese individuals with varying degrees of glucose tolerance. J Clin Endocrinol Metab 1993 76 : 44 48.
24. Hampton SM, Withey L. Monitoring beta cell responses in obese and normal weight subjects - a pilot study. Diabetes Metab 1993 19 : 582 585.
25. Calles-Escandon J, Robbins DC. Loss of early phase of insulin release in humans impairs glucose tolerance and blunts thermic effect of glucose. Diabetes 1987 36 : 1167 1172.
26. Del Prato S. Loss of early insulin secretion leads to postprandial hyperglycaemia. Diabetologia 2003 46 : M2 8.
27. Gerich JE. The genetic basis of type 2 diabetes mellitus: impaired insulin secretion versus impaired insulin sensitivity. Endocr Rev 1998 19 : 491 503.
28. Kahn SE, Prigeon RL, Schwartz RS, Fujimoto WY, Knopp RH, Brunzell JD, Porte D Jr. Obesity, body fat distribution, insulin sensitivity and islet beta-cell function as explanations for metabolic diversity. J Nutr 2001 131 : 354S 360S.
29. Fritsche A, Madaus A, Stefan N, Tschritter O, Maerker E, Teigeler A et al. Relationships among age, proinsulin conversion, and beta-cell function in nondiabetic humans. Diabetes 2002 51 : S234 239.
30. Kahn SE, Leonetti DL, Prigeon RL, Boyko EJ, Bergstom RW, Fujimoto WY. Proinsulin levels predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Japanese-American men. Diabet Med 1996 13 : S63 66.
31. Weiss R, Caprio S, Trombetta M, Taksali SE, Tamborlane WV, Bonadonna R. Beta-cell function across the spectrum of glucose tolerance in obese youth. Diabetes 2005 54 : 1735 1743.
32. Galloway JA, Hooper SA, Spradlin CT, Howey DC, Frank BH, Bowsher RR, Anderson JH. Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience. Diabetes Care 1992 15 : 666 692.
33. Weyer C, Tataranni PA, Bogardus C, Pratley RE. Insulin resistance and insulin secretory dysfunction are independent predictors of worsening of glucose tolerance during each stage of type 2 diabetes development. Diabetes Care 2001 24 : 89 94.
34. Haffner SM, Mykkanen L, Valdez RA, Stern MP, Holloway DL, Monterrosa A, Bowsher RR. Disproportionately increased proinsulin levels are associated with the insulin resistance syndrome. J Clin Endocrinol Metab 1994 79 : 1806 1810.
35. Meier JJ, Butler AE, Galasso R, Butler PC. Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased beta-cell turnover. Diabetes Care 2006 29 : 1554 1559.