메뉴 건너뛰기




Volumn 49, Issue 1, 1998, Pages 83-98

SU-840, a novel synthetic flavonoid derivative of sophoradin, with potent gastroprotective and ulcer healing activity

Author keywords

Gastric blood flow; Gastroprotection; Nitric oxide; Prostaglandins; Sophoradin; Sulfhydryls; Ulcer healing

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; DRUG VEHICLE; FLAVONOID; INDOMETACIN; N ETHYLMALEIMIDE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN E2; SOFALCONE; SOPHORAMINE; SU 840; SUCRALFATE; THIOL DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0031981929     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (14)

References (35)
  • 2
    • 0022553098 scopus 로고
    • Effect of sofalcone on gastric mucosal prostaglandin metabolism in taurocholate induced gastritis in rats
    • Muramatsu M, Tanaka M, Murakami S, Aihara H. Effect of sofalcone on gastric mucosal prostaglandin metabolism in taurocholate induced gastritis in rats. Res Commun Chem Pathol Pharmacol 1986; 53: 289-300.
    • (1986) Res Commun Chem Pathol Pharmacol , vol.53 , pp. 289-300
    • Muramatsu, M.1    Tanaka, M.2    Murakami, S.3    Aihara, H.4
  • 4
    • 0021234351 scopus 로고
    • Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in rats
    • Kimura M, Saziki R, Arai I, Tarumoto Y, Nakane S. Effect of 2'-carboxymethoxy-4,4'-bis(3-methyl-2-butenyloxy) chalcone (sofalcone) on chronic gastric ulcers in rats. Jpn J Pharmacol 1984; 35: 389-96.
    • (1984) Jpn J Pharmacol , vol.35 , pp. 389-396
    • Kimura, M.1    Saziki, R.2    Arai, I.3    Tarumoto, Y.4    Nakane, S.5
  • 6
    • 0022538391 scopus 로고
    • Antiulcer and gastroprotective effects of solon a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins
    • Konturek SJ, Radecki T, Brzozowski T et al. Antiulcer and gastroprotective effects of solon a synthetic flavonoid derivative of sophoradin. Role of endogenous prostaglandins. Eur J Pharmacol 1986; 125: 185-192.
    • (1986) Eur J Pharmacol , vol.125 , pp. 185-192
    • Konturek, S.J.1    Radecki, T.2    Brzozowski, T.3
  • 7
    • 0023395895 scopus 로고
    • Gastroprotective and ulcer healing effects of solon a synthetic flavonoid derivative of sophoradin
    • Konturek SJ, Brzozowski T, Drozdowicz D, Pawlik W, Sendur R. Gastroprotective and ulcer healing effects of solon a synthetic flavonoid derivative of sophoradin. Hepatogastroenterology 1987; 34: 164-170.
    • (1987) Hepatogastroenterology , vol.34 , pp. 164-170
    • Konturek, S.J.1    Brzozowski, T.2    Drozdowicz, D.3    Pawlik, W.4    Sendur, R.5
  • 8
    • 0023008033 scopus 로고
    • Effect of sofalcone on acute gastric mucosal lesions induced by aspirin and ethanol in reference to the biosynthesis of gastric mucosal glycoprotein
    • Muramatsu M, Murakami S, Arai I et al. Effect of sofalcone on acute gastric mucosal lesions induced by aspirin and ethanol in reference to the biosynthesis of gastric mucosal glycoprotein. Res Commun Chem Pathol Pharmacol 1986; 54: 321-37.
    • (1986) Res Commun Chem Pathol Pharmacol , vol.54 , pp. 321-337
    • Muramatsu, M.1    Murakami, S.2    Arai, I.3
  • 9
    • 0023567170 scopus 로고
    • Enzymatic sulfation of mucin in gastric mucosa effect of sofalcone sucralfate and aspirin
    • Slomiany BL, Liau YH, Carter SR, Sarosiek I, Tsukada H, Slomiany A. Enzymatic sulfation of mucin in gastric mucosa effect of sofalcone sucralfate and aspirin. Digestion 1987; 38: 178-86.
    • (1987) Digestion , vol.38 , pp. 178-186
    • Slomiany, B.L.1    Liau, Y.H.2    Carter, S.R.3    Sarosiek, I.4    Tsukada, H.5    Slomiany, A.6
  • 10
    • 0023231224 scopus 로고
    • Enzymatic sulfation of gastric mucous glycoprotein in rat changes in glycoprotein sulfotransferase activity with stress and antiulcer agent sofalcone
    • Murakami S, Muramatsu M, Aihara H, Honda A, Mori Y. Enzymatic sulfation of gastric mucous glycoprotein in rat changes in glycoprotein sulfotransferase activity with stress and antiulcer agent sofalcone. Res Commun Chem Pathol Pharmacol 1987; 57: 77-98.
    • (1987) Res Commun Chem Pathol Pharmacol , vol.57 , pp. 77-98
    • Murakami, S.1    Muramatsu, M.2    Aihara, H.3    Honda, A.4    Mori, Y.5
  • 11
    • 0024268180 scopus 로고
    • Effect of sofalcone on gastric mucous glycoprotein in experimental gastritis induced by sodium taurocholate
    • Murakami S, Yamada H, Muramatsu M et al. Effect of sofalcone on gastric mucous glycoprotein in experimental gastritis induced by sodium taurocholate. Res Commun Chem Pathol Pharmacol 1988; 62: 461-82.
    • (1988) Res Commun Chem Pathol Pharmacol , vol.62 , pp. 461-482
    • Murakami, S.1    Yamada, H.2    Muramatsu, M.3
  • 13
    • 0026563844 scopus 로고
    • Effects of sofalcone administration on the physicochemical properties of gastric mucus
    • Slomiany BL, Tamura S, Piotrowski J, Slomiany A. Effects of sofalcone administration on the physicochemical properties of gastric mucus. J Clin Gastroenterol 1992; 14: Suppl 1: 88-93.
    • (1992) J Clin Gastroenterol , vol.14 , Issue.1 SUPPL. , pp. 88-93
    • Slomiany, B.L.1    Tamura, S.2    Piotrowski, J.3    Slomiany, A.4
  • 14
    • 0027427628 scopus 로고
    • Effect of sofalcone on gastric mucosal injury induced by ischemia reperfusion and its antioxidant properties
    • Yoshikawa T, Nakamura S, Takahashi S, Naito Y, Kondo M. Effect of sofalcone on gastric mucosal injury induced by ischemia reperfusion and its antioxidant properties. J Clin Gastroenterol 1993; 17: Suppl 1: 111-115.
    • (1993) J Clin Gastroenterol , vol.17 , Issue.1 SUPPL. , pp. 111-115
    • Yoshikawa, T.1    Nakamura, S.2    Takahashi, S.3    Naito, Y.4    Kondo, M.5
  • 16
    • 0025108137 scopus 로고
    • Mechanisms of gastroprotection
    • 74
    • Konturek SJ. Mechanisms of gastroprotection. Scand J Gastroenterol 1990; 25: Suppl. 1: 74: 15-28
    • (1990) Scand J Gastroenterol , vol.25 , Issue.1 SUPPL. , pp. 15-28
    • Konturek, S.J.1
  • 18
    • 0023222921 scopus 로고
    • Gastric protection by agents altering gastric mucosal sulfhydryls. Role of prostaglandins
    • Konturek SJ, Brzozowski T, Piastucki I, Radecki T, Dupuy D, Szabo S. Gastric protection by agents altering gastric mucosal sulfhydryls. Role of prostaglandins. Digestion 1987; 37: 65-71.
    • (1987) Digestion , vol.37 , pp. 65-71
    • Konturek, S.J.1    Brzozowski, T.2    Piastucki, I.3    Radecki, T.4    Dupuy, D.5    Szabo, S.6
  • 19
    • 0026647761 scopus 로고
    • Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury
    • Konturek SJ, Brzozowski T, Majka J, Dembinski A, Slomiany A. Transforming growth factor alpha and epidermal growth factor in protection and healing of gastric mucosal injury. Scand J Gastroenterol 1992; 27: 649-655.
    • (1992) Scand J Gastroenterol , vol.27 , pp. 649-655
    • Konturek, S.J.1    Brzozowski, T.2    Majka, J.3    Dembinski, A.4    Slomiany, A.5
  • 22
    • 0019825246 scopus 로고
    • Sulfhydryl compounds may mediate gastric cytoprotection
    • Szabo S, Trier JS, Frankel PW. Sulfhydryl compounds may mediate gastric cytoprotection. Science 1981; 214: 200-202.
    • (1981) Science , vol.214 , pp. 200-202
    • Szabo, S.1    Trier, J.S.2    Frankel, P.W.3
  • 23
    • 0028049821 scopus 로고
    • Role of gastric blood flow neutrophil infiltration and mucosal cell proliferation in gastric adaptation to aspirin in the rat
    • Konturek SJ, Brzozowski T, Stachura J, Dembinski A, Majka J. Role of gastric blood flow neutrophil infiltration and mucosal cell proliferation in gastric adaptation to aspirin in the rat. Gut 1994; 35: 1189-1196.
    • (1994) Gut , vol.35 , pp. 1189-1196
    • Konturek, S.J.1    Brzozowski, T.2    Stachura, J.3    Dembinski, A.4    Majka, J.5
  • 25
    • 0015023481 scopus 로고
    • A method for experimental penetrating ulcers in rats
    • Okabe S, Pfeifer CI, Roth IL. A method for experimental penetrating ulcers in rats. Am J Dig Dis 1971; 16: 277-284.
    • (1971) Am J Dig Dis , vol.16 , pp. 277-284
    • Okabe, S.1    Pfeifer, C.I.2    Roth, I.L.3
  • 26
    • 0028826599 scopus 로고
    • Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide prostaglandins, gastrin and polyamines
    • Brzozowski T, Konturek SJ, Drozdowicz D, Dembinski A, Stachura J. Healing of chronic gastric ulcerations by L-arginine. Role of nitric oxide prostaglandins, gastrin and polyamines. Digestion 1995; 56: 463-471.
    • (1995) Digestion , vol.56 , pp. 463-471
    • Brzozowski, T.1    Konturek, S.J.2    Drozdowicz, D.3    Dembinski, A.4    Stachura, J.5
  • 28
    • 0021680561 scopus 로고
    • Effects of sofalcone on necrotizing agents induced gastric lesions and on endogenous prostaglandins in rats stomachs
    • Saziki R, Arai I, Isobe Y, Hirose H, Aihara H. Effects of sofalcone on necrotizing agents induced gastric lesions and on endogenous prostaglandins in rats stomachs. J Pharmacobiodyn 1984; 7: 791-797.
    • (1984) J Pharmacobiodyn , vol.7 , pp. 791-797
    • Saziki, R.1    Arai, I.2    Isobe, Y.3    Hirose, H.4    Aihara, H.5
  • 29
    • 0024226992 scopus 로고
    • 2 and sofalcone a synthetic flavonoid derivative of sophoradin against ethanol
    • 2 and sofalcone a synthetic flavonoid derivative of sophoradin against ethanol. Digestion 1988; 41: 61-67.
    • (1988) Digestion , vol.41 , pp. 61-67
    • Arakawa, T.1    Nakamura, A.2    Yamada, H.3
  • 31
    • 0022506131 scopus 로고
    • Prostaglandin cytoprotection linked to the adhesion of mucous glycoprotein to the gastric epithelium
    • Murakami S, Fujimoto N, Mori Y. Prostaglandin cytoprotection linked to the adhesion of mucous glycoprotein to the gastric epithelium. J Pharmacobiodyn 1986; 9: 359-67.
    • (1986) J Pharmacobiodyn , vol.9 , pp. 359-367
    • Murakami, S.1    Fujimoto, N.2    Mori, Y.3
  • 33
    • 0028900103 scopus 로고
    • Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori
    • Kodama R, Fujioka T, Fujiyama K, Kawasaki H, Kubota T, Nasu M. Combination therapy with clarithromycin and sofalcone for eradication of Helicobacter pylori. Eur J Gastroenterol Hepatol 1994; 6: Suppl 1: 125-8.
    • (1994) Eur J Gastroenterol Hepatol , vol.6 , Issue.1 SUPPL. , pp. 125-128
    • Kodama, R.1    Fujioka, T.2    Fujiyama, K.3    Kawasaki, H.4    Kubota, T.5    Nasu, M.6
  • 34
    • 0025786617 scopus 로고
    • Effect of carbonoxolone on the biological activity of nitric oxide: Relation to gastroprotection
    • Dembinska-Kiec A, Pallapies D, Simmet T, Peskar BM, Peskar MA. Effect of carbonoxolone on the biological activity of nitric oxide: relation to gastroprotection. Br J Pharmacol 1991; 104: 811-816.
    • (1991) Br J Pharmacol , vol.104 , pp. 811-816
    • Dembinska-Kiec, A.1    Pallapies, D.2    Simmet, T.3    Peskar, B.M.4    Peskar, M.A.5
  • 35
    • 0028897361 scopus 로고
    • Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats
    • Konturek SJ, Brzozowski T, Pytko-Polonczyk J, Drozdowicz D. Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats. Eur J Pharmacol 1995; 273: 57-62.
    • (1995) Eur J Pharmacol , vol.273 , pp. 57-62
    • Konturek, S.J.1    Brzozowski, T.2    Pytko-Polonczyk, J.3    Drozdowicz, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.