Over-expression of angiotensin converting enzyme-1 augments cardiac hypertrophy in transgenic rats

Human Molecular Genetics

Volumn 13, Issue 14, 2004, Pages 1441-1450

  Tian, Xiao Li ^a   Pinto, Yigal Martin ^a   Costerousse, Olivier ^a   Franz, Wolfgang M ^b   Lippoldt, Andrea ^c   Hoffmann, Sigrid ^c   Unger, Thomas ^d   Paul, Martin ^a,e  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF LÜBECK   (Germany)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN I; ATRIAL NATRIURETIC FACTOR; COLLAGEN TYPE 3; DIPEPTIDYL CARBOXYPEPTIDASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MYOSIN LIGHT CHAIN; RIBONUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART PERFUSION; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; HYPERTENSION; IN SITU HYBRIDIZATION; INTRON; ISOLATED HEART; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; TRANSGENIC ANIMAL;

ANGIOTENSIN I; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CARDIOMEGALY; COLLAGEN TYPE III; HUMANS; HYPERTENSION; INTRONS; MALE; MYOCARDIUM; PEPTIDYL-DIPEPTIDASE A; RATS;

EID: 3543134133     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh147     Document Type: Article

References (58)

1. Tian, X.L. and Paul, M. (2003) Species-specific splicing and expression of angiotensin converting enzyme. Biochem. Pharmacol., 66, 1037-1044.
2. Kang, N., Walther, T., Tian, X.L., Bohlender, J., Fukamizu, A., Ganten, D. and Bader, M. (2002) Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis. J. Mol. Med., 80, 359-366.
3. Campbell, D.J., Alexiou, T., Xiao, H.D., Fuchs, S., McKinley, M.J., Corvol, P. and Bernstein, K.E. (2004) Effect of reduced angiotensin-converting enzyme gene expression and angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptide levels in mice. Hypertension, 43, 854-859.
4. Duncan, A.M., Burrell, L.M., Kladis, A. and Campbell, D.J. (1996) Effects of angiotensin-converting enzyme inhibition on angiotensin and bradykinin peptides in rats with myocardial infarction. J. Cardiovasc. Pharmacol., 28, 746-754.
5. Wolf, G. and Wenzel, U.O. (2004) Angiotensin II and cell cycle regulation. Hypertension, 43, 693-698.
6. Xiao, H.D., Fuchs, S., Cole, J.M., Disher, K.M., Sutliff, R.L. and Bernstein, K.E. (2003) Role of bradykinin in angiotensin converting enzyme (ACE) knockout mice. Am. J. Physiol. Heart Circ. Physiol., 284, H1969-H1977.
7. Paul, M. and Ganten, D. (1992) The molecular basis of cardiovascular hypertrophy: the role of the renin-angiotensin system. J. Cardiovasc. Pharmacol., 19, S51-S58.
8. Schunkert, H., Dzau, V.J., Tang, S.S., Hirsch, A.T., Apstein, C.S. and Lorell, B.H. (1990) Increased rat cardiac angiotensin converting enzyme activity and mRNA expression in pressure overload left ventricular hypertrophy. Effects on coronary resistance, contractility and relaxation. J. Clin. Invest., 86, 1913-1920.
9. Busatto, V.C., Cicilini, M.A. and Mill, J.G. (1997) Increased angiotensin-converting enzyme activity in the left ventricle after infarction. Braz. J. Med. Biol. Res., 30, 679-687.
10. Paul, M., Pinto, Y.M., Schunkert, H., Ganten, D. and Bohm, M. (1994) Activation of the renin-angiotensin system in heart failure and hypertrophy - studies in human hearts and transgenic rats. Eur. Heart J., 15, 63-67.
11. Bruckschlegel, G., Holmer, S.R., Jandeleit, K., Grimm, D., Muders, F., Kromer, E.P., Riegger, G.A. and Schunkert, H. (1995) Blockade of the renin-angiotensin system in cardiac pressure-overload hypertrophy in rats. Hypertension, 25, 250-259.
12. Ruzicka, M. and Leenen, F.H. (1995) Relevance of blockade of cardiac and circulatory angiotensin-converting enzyme for the prevention of volume overload-induced cardiac hypertrophy. Circulation, 91, 16-19.
13. Clozel, J.P., Kuhn, H. and Hefti, F. (1989) Effects of chronic ACE inhibition on cardiac hypertrophy and coronary vascular reserve in spontaneously hypertensive rats with developed hypertension. J. Hypertens., 7, 267-275.
14. Gohlke, P., Kuwer, I., Schnell, A., Amann, K., Mall, G. and Unger, T. (1997) Blockade of bradykinin B2 receptors prevents the increase in capillary density induced by chronic angiotensin-converting enzyme inhibitor treatment in stroke-prone spontaneously hypertensive rats. Hypertension, 29, 478-482.
15. Sun, Y., Cleutjens, J.P., Diaz, A.A. and Weber, K.T. (1994) Cardiac angiotensin converting enzyme and myocardial fibrosis in the rat. Cardiovasc. Res., 28, 1423-1432.
16. Linz, W., Wiemer, G. and Scholkens, B.A. (1997) Beneficial effects of bradykinin on myocardial energy metabolism and infarct size. Am. J. Cardiol., 80, 118A-123A.
17. Duncan, A.M., Burrell, L.M., Kladis, A. and Campbell, D.J. (1997) Angiotensin and bradykinin peptides in rats with myocardial infarction. J. Cardiovasc. Fail., 3, 41-52.
18. Dzau, V.J. (1989) Clinical implications for therapy: possible cardioprotective effects ofACE1 inhibition. Br. J. Clin. Pharmacol., 28, 183S-187S.
19. Gustafsson, F., Torp-Pedersen, C., Burchardt, H., Buch, P., Seiback, M., Kjoller, E., Gustafsson, I. and Kober, L. (2004) Female sex is associated with a better long-term survival in patients hospitalized with congestive heart failure. Eur. Heart J., 25, 129-135.
20. Kober, L., Torp, P.C., Carlsen, J.E., Bagger, H., Eliasen, P., Lyngborg, K., Videbaek, J., Cole, D.S., Auclert, L. and Pauly, N.C. Trandolapril Cardiac Evaluation (TRACE) Study Group (1995) A clinical trial of the angiotensin-converting-enzyme inhibitor trandolapril in patients with left ventricular dysfunction after myocardial infarction. N. Engl. J. Med., 333, 1670-1676.
21. Pitt, B. (1994) Pharmacologic treatment of heart failure with standard drugs. Curr. Opin. Cardiol., 9, 289-294.
22. Rigat, B., Hubert, C., Alhenc-Gelas, F., Cambien, F., Corvol, P. and Soubrier, F. (1990) An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest., 86, 1343-1346.
23. Danser, A.H., Schalekamp, M.A., Bax, W.A., van den Brink, A.M., Saxena, P.R., Riegger, G.A. and Schunkert, H. (1995) Angiotensin-converting enzyme in the human heart. Effect of the deletion/insertion polymorphism. Circulation, 92, 1387-1388.
24. Cambien, F., Poirier, O., Lecerf, L., Evans, A., Cambou, J.P., Arveiler, D., Luc, G., Bard, J.M., Bara, L., Ricard, S. et al. (1992) Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature, 359, 641-644.
25. Iwai, N., Ohmichi, N., Nakamura, Y. and Kinoshita, M. (1994) DD genotype of the angiotensin-converting enzyme gene is a risk factor for left ventricular hypertrophy. Circulation, 90, 2622-2628.
26. Schunkert, H., Hense, H.W., Holmer, S.R., Stender, M., Perz, S., Keil, U., Lorell, B.H. and Riegger, G.A. (1994) Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N. Engl. J. Med., 330, 1634-1638.
27. Lindpaintner, K., Lee, M., Larson, M.G., Rao, V.S., Pfeffer, M.A., Ordovas, J.M., Schaefer, E.J., Wilson, A.F., Wilson, P.W., Vasan, R.S. et al. (1996) Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. N. Engl. J. Med., 334, 1023-1028.
28. Schieffer, B., Wirger, A., Meybrunn, M., Seitz, S., Holtz, J., Riede, U.N. and Drexler, H. (1994) Comparative effects of chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on cardiac remodeling after myocardial infarction in the rat. Circulation, 89, 2273-2282.
29. Ruzicka, M., Skarda, V. and Leenen, F. H. (1995) Effects of ACE inhibitors on circulating versus cardiac angiotensin II in volume overload-induced cardiac hypertrophy in rats. Circulation, 92, 3568-3573.
30. Gohlke, P., Linz, W., Scholkens, B.A., Kuwer, I., Bartenbach, S., Schnell, A. and Unger, T. (1994) Angiotensin-converting enzyme inhibition improves cardiac function. Role of bradykinin. Hypertension, 23, 411-418.
31. Rupert, J.L., Kidd, K.K., Norman, L.E., Monsalve, M.V., Hochachka, P.W. and Devine, D.V. (2003) Genetic polymorphisms in the renin-angiotensin system in high-altitude and low-altitude native American populations. Ann. Hum. Genet., 67, 17-25.
32. Tsai, C.T., Fallin, D., Chiang, F.T., Hwang, J.J., Lai, L.P., Hsu, K.L., Tseng, C.D., Liau, C.S. and Tseng, Y.Z. (2003) Angiotensinogen gene haplotype and hypertension: interaction with ACE gene I allele. Hypertension, 41, 9-15.
33. Kimura, M., Yokota, M., Fujimura, T., Kato, S., Hirayama, H., Tsunekawa, A., Maeda, M., Inagaki, H., Ogawa, S., Nakashima, N. et al. (1997) Association of a deletion polymorphism of the angiotensin-converting enzyme gene with left-ventricular hypertrophy in Japanese women with essential hypertension; multicenter study of 1,919 subjects. Cardiology, 88, 309-314.
34. Anderson, J.L., Carlquist, J.F., King, G.J., Morrison, L., Thomson, M.J., Ludwig, E.H., Muhlestein, J.B., Bair, T.L. and Ward, R.H. (1998) Angiotensin-converting enzyme genotypes and risk for myocardial infarction in women. J. Am. Coll. Cardiol., 31, 790-796.
35. Sadoshima, J., Xu, Y., Slayter, H.S. and Izumo, S. (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell, 75, 977-984.
36. Nagano, M., Higaki, J., Mikami, H., Nakamaru, M., Higashimori, K., Katahira, K., Tabuchi, Y., Moriguchi, A., Nakamura, F. and Ogihara, T. (1991) Converting enzyme inhibitors regressed cardiac hypertrophy and reduced tissue angiotensin II in spontaneously hypertensive rats. J. Hypertens., 9, 595-599.
37. Chen, R., Iwai, M., Wu, L., Suzuki, J., Min, L.J., Shiuchi, T., Sugaya, T., Liu, H.W., Cui, T.X. and Horiuchi, M. (2003) Important role of nitric oxide in the effect of angiotensin-converting enzyme inhibitor imidapril on vascular injury. Hypertension, 42, 542-547.
38. Nickenig, G., Laufs, U., Schnabel, P., Knorr, A., Paul, M. and Bohm, M.P. (1997) Down-regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen-2) 27 rats. Br. J. Pharmacol., 121, 134-140.
39. Lopez, J.J., Lorell, B.H., Ingelfinger, J.R., Weinberg, E.O., Schunkert, H., Diamant, D. and Tang, S.S. (1994) Distribution and function of cardiac angiotensin AT1- and AT2-receptor subtypes in hypertrophied rat hearts. Am. J. Physiol., 267, H844-H852.
40. Haefliger, J.A., Bergonzelli, G., Waeber, G., Aubert, J.F., Nussberger, J., Gavras, H., Nicod, P. and Waeber, B. (1995) Renin and angiotensin II receptor gene expression in kidneys of renal hypertensive rats. Hypertension, 26, 733-737.
41. Moritz, K., Koukoulas, I., Albiston, A. and Wintour, E.M. (2000) Angiotensin II infusion to the midgestation ovine fetus: effects on the fetal kidney. Am. J. Physiol. Regal. Integr. Comp. Physiol., 279, R1290-R1297.
42. Wiesner, R.J., Ehmke, H., Faulhaber, J., Zak, R. and Ruegg, J.C. (1997) Dissociation of left ventricular hypertrophy, beta-myosin heavy chain gene expression, and myosin isoform switch in rats after ascending aortic stenosis. Circulation, 95, 1253-1259.
43. Morimoto, A., Nishikimi, T., Yoshihara, F., Horio, T., Nagaya, N., Matsuo, H., Dohi, K. and Kangawa, K. (1999) Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats. Hypertension, 33, 1146-1152.
44. Hirano, S., Imamura, T., Onitsuka, H., Matsuo, T., Kitamura, K., Koiwaya, Y. and Eto, T. (2002) Rapid increase in cardiac adrenomedullin gene expression caused by acute pressure overload: effect of the renin-angiotensin system on gene expression. Circ. J., 66, 397-402.
45. Ingert, C., Grima, M., Coquard, C., Barthelmebs, M. and Imbs, J.L. (2002) Contribution of angiotensin II internalization to intrarenal angiotensin II levels in rats. Am. J. Physiol. Renal. Physiol., 283, F1003-F1010.
46. Yayama, K., Matsuoka, S., Nagaoka, M., Shimazu, E., Takano, M. and Okamoto, H. (2003) Down-regulation of bradykinin B2-receptor mRNA in the heart in pressure-overload cardiac hypertrophy in the rat. Biochem. Pharmacol., 65, 1017-1025.
47. Prasad, N., O'Kane, K.P., Johnstone, H.A., Wheeldon, N.M., McMahon, A.D., Webb, D.J. and MacDonald, T.M. (1994) The relationship between blood pressure and left ventricular mass in essential hypertension is observed only in the presence of the angiotensin-converting enzyme gene deletion allele. Quant. J. Med., 87, 659-662.
48. Sasaki, M., Oki, T., Iuchi, A., Tabata, T., Yamada, H., Manabe, Fukuda, K., Abe, M. and Ito, S. (1996) Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies. J. Hypertens., 14, 1403-1408.
49. Gharavi, A.G., Lipkowitz, M.S., Diamond, J.A., Jhang, J.S. and Phillips, R.A. (1996) Deletion polymorphism of the angiotensin-converting enzyme gene is independently associated with left ventricular mass and geometric remodeling in systemic hypertension. Am. J. Cardiol., 77, 1315-1319.
50. Montgomery, H.E., Clarkson, P., Dollery, C.M., Prasad, K., Losi, M.A., Hemingway, H., Starters, D., Jubb, M., Girvain, M., Varnava, A. et al. (1997) Association of angiotensin-converting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation, 96, 741-747.
51. Hernandez, D., de la Rosa, A., Barragan, A., Barrios, Y., Salido, E., Torres, A., Martin, B., Laynez, I., Duque, A., De Vera, A. et al. (2003) The ACE1/DD genotype is associated with the extent of exercise-induced left ventricular growth in endurance athletes. J. Am. Coll. Cardiol., 42, 527-532.
52. Soubrier, F., Alhenc-Gelas, F., Hubert, C., Allegrini, J., John, M., Tregear, G. and Corvol, P. (1988) Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. USA, 85, 9386-9390.
53. Franz, W.M., Breves, D., Klingel, K., Brem, G., Hofschneider, P.H. and Kandolf, R. (1993) Heart-specific targeting of firefly luciferase by the myosin light chain-2 promoter and developmental regulation in transgenic mice. Circ. Res., 73, 629-638.
54. Paul, M., Wagner, J., Hoffmann, S., Urata, H. and Ganten, D. (1994) Transgenic rats: new experimental models for the study of candidate genes in hypertension research. Annu. Rev. Physiol., 56, 811-829.
55. Tian, X.L., Chen, L.Y. and Hu, R.L. (1995) Transgenic Animals: Principles, Techniques and Applications. Changchun Science and Technology Press, Changchun.
56. Costerousse, O., Allegrini, J., Huang, H., Bounhik, J. and Alhenc, G.F. (1994) Regulation of ACE gene expression and plasma levels during rat postnatal development. Am. J. Physiol., 267, E745-E753.
57. Lippoldt, A., Bunnemann, B., Ueki, A., Rosen, L., Cintra, A., Hasselrot, U., Metzger, R., Hilgenfeldt, U., Brosnihan, B., Ganten, D. et al. (1994) On the plasticity of the cerebellar renin-angiotensin system: localization of components and effects of mechanical perturbation. Brain Res., 668, 144-159.
58. Linz, W., Scholkens, B.A. and Ganten, D. (1989) Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats. Clin. Exp. Hypertens. A., 11, 1325-1350.