Down-regulation of aortic and cardiac AT1 receptor gene expression in transgenic (mRen-2) 27 rats

British Journal of Pharmacology

Volumn 121, Issue 1, 1997, Pages 134-140

  Nickenig, G ^a   Laufs, U ^a   Schnabel, P ^a   Knorr, A ^c   Paul, M ^b   Bohm M ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c BAYER AG   (Germany)

Author keywords

Angiotensin II receptor; Cardiac hypertrophy; Hypertension; Renin AT1 receptor; Transgenes

Indexed keywords

ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR; MESSENGER RNA; RADIOLIGAND; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; GENE EXPRESSION; GROWTH; HEART; HEART CONTRACTION; HEART LEFT ATRIUM; HEART LEFT VENTRICLE; HEART PERFORMANCE; HEART VENTRICLE HYPERTROPHY; HYPERTENSION; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RAT; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR GENE; TRANSGENIC ANIMAL;

EID: 0030892281     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701088     Document Type: Article

References (42)

1. AGUILERA, G. & CATT, K. (1981). Regulation of vascular angiotensin II receptors during altered sodium intake. Circ. Res., 49, 751 - 758.
2. ARRIBAS, S., SANCHEZ-FERRER, F., PEIRO, C., PONTE, A., SALAICES, M. & MARIN, J. (1994). Functional vascular reninangiotensin system in hypertensive transgenic rats for the mouse renin gene Ren-2. Gen. Pharmacol., 25, 1163 - 1170.
3. BAKER, K.M. & ACETO, J.F. (1990). Angiotensin II stimulation of protein synthesis and cell growth in chick heart cells. Am. J. Physiol., 259, H610 - H618.
4. BAKER, K.M. & SINGER, H.A. (1988). Identification and characterization of guinea pig angiotensin II ventricular and atrial receptors: coupling to inositol phosphate production. Circ. Res., 62, 896 - 904.
5. BELLUCI, A. & WILKES, B.M. (1984). Mechanism of sodium modulation of glomerular angiotensin receptors in the rat. Circ. Res., 49, 751 - 758.
6. BÖHM, M., BEUCKELMANN, D., BROWN, L., FEILER, G., LORENZ, B., NÄBAUER, M., KEMKES, B. & ERDMANN, E. (1988). Reduction of beta-adrenoceptor density and evaluation of positive inotropic responses in isolated, diseased human myocardium. Eur. Heart. J., 9, 844 - 852.
7. BRISTOW, M.R., GINSBURG, R., MINOBE, W., CIBICCIOTI, R.S., SAGEMAN, W.S., LURIE, K., BILLINGHAM, M.E., HARRISON D.C. & STINSON, E.B. (1982). Decreased catecholamine sensitivity and beta-adrenergic receptor density in failing human hearts. N. Engl. J. Med., 307, 205 - 21127.
8. BRODDE, O.E. (1987). β1- and β2-adrenoceptors in the human heart: properties, function, and alterations in chronic heart failure Pharmacol. Rev., 43, 203 - 242.
9. CAPONI, A.M., AGUILERA, G., FAKUNDING, J.L. & CATT, K.J. (1981). Angiotensin II: receptors and mechanisms of action. In Biochemical Regulation of Blood Pressure, ed. Soffer, R.L. pp. 205 - 262. New York: John Wiley & Sons.
10. DEMPSEY, P.J., MCCALLUM, Z.T., KENT, K.M. & COOPER, T. (1971). Direct myocardial effects of angiotensin II. Am. J. Physiol., 220, 477 - 481.
11. DZAU, V., COLUCCI, W., HOLLENBERG, N. & WILLIAMS, G. (1981). Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure. Circulation, 63, 645 - 656.
12. FREER, R., PAPPANO, A., PEACH, M., BING, K., MCLEAN, M., VOGEL S. & SPERELAKIS, N. (1976). Mechanism for the positive inotropic effect of angiotensin II on isolated cardiac muscle. Circ. Res., 39, 178 - 184.
13. GANTEN, D., LINDPAINTER, K., GANTEN, U., PETERS, J., ZIMMERMANN, F., BADER, M. & MULLINS, J. (1991). Transgenic rats: new animal models in hypertension research. Hypertension, 17, 843 - 855.
14. GARDINER, S.M., MARCH, J.E., KEMP, P.A., MULLINS, J.J. & BENNETT, T. (1995). Haemodynamic effects of losartan and the endothelin antagonist, SB 209670, in conscious, transgenic ((mRen-2)27), hypertensive rats. Br. J. Pharmacol., 116, 2237 - 2244.
15. GROSSMAN, W., JONES D. & MCLAURIN, K.P. (1975). Wall stress and pattern of hypertrophy in the human left ventricle. J. Clin. Invest., 58, 56 - 64.
16. GUNTHER, S., GIMBRONE, Jr. M.A. & ALEXANDER, R.W. (1980). Regulation by angiotensin II of its receptor in resistance vessels. Nature, 287, 230 - 232.
17. HADCOCK, J.R., WANG, H. & MALBON, C.C. (1989). Agonist induced destabilization of beta-adrenergic receptor mRNA. J. Biol. Chem., 264, 19928 - 19933.
18. HILGERS, K.F., PETERS, J., VEELKEN, R., SOMMER, M., RUPPRECHT, G., GANTEN, D., LUFT, F.C. & MANN, J.F.E. (1992). Increased vascular angiotensin formation in female rats harboring the mouse Ren-2 gene. Hypertension, 19, 687 - 691.
19. HIRAKATA, H., FOUAD, F.M., BUMPUS, F.M., KHOSLA, M., HEALY, B., HUSAIN, A., URATA, H. & KUMAGAI, H. (1990). Enhanced positive inotropic responses to angiotensin I in isolated cardiomyopathic hamster heart in the presence of captopril. Cric. Res., 66, 891 - 899.
20. HOLUBARSCH, C., HASENFUSS, G., SCHMIDT-SCHWEDA, S., KNORR, A., PIESKE, B., RUF, T., FASOL, R. & JUST, H. (1993). Angiotensin I and II exert inotropic effects in atrial but not in ventricular human myocardium. Circulation, 88, 1228 - 1234.
21. ISHIHATA, A. & ENDOH, M. (1993). Pharmacological characteristics of the positive inotropic effect of angiotensin II in the rabbit ventricular myocardium. Br. J. Pharmacol., 108, 999 - 1005.
22. ISHIHATA, A. & ENDOH, M. (1995). Species-related differences in inotropic effects of angiotensin II in mammalian ventricular muscle: receptors, subtypes and phosphoinositide hydrolysis. Br. J. Pharmacol., 114, 447 - 453.
23. KANNEL, W.B., CASTELLI, W.P., MCNAMARA, P.M., MCKEE, P.A. & FEINLEIB, M (1972). Role of blood pressure in the development of congestive heart failure: the Framingham Study. N. Engl. J. Med., 287, 781 - 787.
24. KHAIRALLAH, P.A. & KANABUS, J. (1983). Angiotensin and myocardial protein synthesis. In Perspective in Cardiovascular Research, ed. Tarazi, R.C. & Dunbar, J.B. Vol. 8. pp. 337 - 347. New York: Raven Press.
25. KIM, S., OHTA, K., HAMAGUCHI, A., YUKIMURA, T., MIURA, K. & IWAO, H. (1995). Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in rats. Hypertension, 25, 1252 - 1259.
26. KOBAYASHI, M., FURUKAWA, Y. & CHIBA, S. (1978). Positive chronotropic and inotropic effects of angiotensin II in the dog heart. Eur. J. Pharmacol., 501, 17 - 23.
27. KOBAYASHI, T., HAMADA, H., OKAYAMA, H., SHIGEMATSU, Y., SUMIMOTO, T. & HIWADA, K. (1995). Contractile properties of left ventricular myocytes isolated from spontaneously hypertensive rats: effect of angiotensin II. J. Hypertens., 13, 1803 - 1807.
28. 1 receptor by transcriptional and posttranscriptional mechanisms: evidence for homologous and heterologous regulation. Mol. Pharmacol., 48, 601 - 609.
29. LENZ, O., SCHMID, B., KILTER, H., LAROSEE, K., FLESCH, M., KUHN-REGNIER, F., SÜDKAMP, M. & BÖHM, M. (1995). Effects of angiotensin II and angiotensin-converting enzyme inhibitors on human myocardium. Eur. J. Pharmacol., 294, 17 - 27.
30. LO, M., MEDEIROS, I.A., MULLINS, J.J., GANTEN, D., BARRES, C., CERUTI, C., VINCENT, M. & SASSARD, J. (1993). High blood pressure maintenance in transgenic mRen-2 vs. Lyon genetically hypertensive rats. Am. J. Physiol., 265, R180 - R186.
31. LÜSCHER, T.F. (1994). Endothelin, endothelin receptors, and endothelin antagonists. Curr. Op. Nephrol. Hypertension, 3, 92 - 98.
32. MORIGUCHI, A., BROSNIHAN, K.B., KUMAGAI, H., GANTEN, D. & FERRARIO, C.M. (1994). Mechanisms of hypertension in transgenic rats expressing the mouse Ren-2 gene. Am. J. Physiol., 266, R1273 - R1279.
33. MULLINS, J.J., PETERS, J. & GANTEN, D. (1990). Fulminant hypertension in transgenic rats harbouring the mouse Ren-2 gene. Nature, 3, 541 - 544.
34. NEYSES, L. & VETTER, H. (1990). Isolated myocardial cells: a new tool for the investigation of hypertensive heart disease. J. Hypertens., 8(Suppl.4), S99 - S102.
35. NICKENIG, G. & MURPHY, T.J. (1994). Down-regulation by growth factors of vascular smooth muscle angiotensin receptor gene expression. Mol. Pharmacol., 46, 653 - 659.
36. NICKENIG, G. & MURPHY, T.J. (1996). Enhanced AT1 receptor mRNA degradation and induction of polyribosomal mRNA binding proteins by angiotensin II in vascular smooth muscle cells. Mol. Pharmacol., 50, 743 - 751.
37. PEACH, M.J. (1977). Renin-angiotensin system: biochemistry and mechanism of action. Physiol. Rev., 57, 313 - 370.
38. REGITZ-ZAGROSEK, V., FRIEDEL, N., HEYMANN, A., BAUER, P., NEUß, M., ROLFS, A., STEFFEN, C., HILDEBRANDT, A., HETZER, R. & FLECK, E. (1995). Regulation, chamber localization, and subtype distribution of angiotensin II receptors in human hearts. Circulation, 91, 1461 - 1471.
39. ROGERS, T.B. (1984). High affinity angiotensin II receptors in myocardial sarcolemmal membranes. J. Biol. Chem., 259, 8106 - 8113.
40. SADOSHIMA, J. & IZUMO, S. (1993). Molecular characterization of angiotensin II-induced hypertrophy of cardiac myocyates and hyperplasia of cardiac fibroblasts. Circ. Res., 73, 413 - 423.
41. SCHIFFRIN, E.L., GUTKOWSKA, J. & GENEST, J. (1984). Effect of angiotensin II and desoxycorticosterone infusion on vascular angiotensin II receptors in rats. Am. J. Physiol., 246, H608 - 614.
42. SPANN, J.R., BUCINO, R.A., SONNENBLICK, E.H. & BRAUNWALD, E. (1967). Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ. Res., 21, 341 - 354.