Species-specific splicing and expression of angiotensin converting enzyme

Biochemical Pharmacology

Volumn 66, Issue 6, 2003, Pages 1037-1044

  Tian, Xiao Li ^a,b,c   Paul, Martin ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

ACE isoforms; Cardiac hypertrophy; Cloning; Male maturation; RNA splicing

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ISOENZYME;

ALTERNATIVE RNA SPLICING; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; FRAMESHIFT MUTATION; GENDER; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE LOCATION; GENETIC ANALYSIS; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; INTRON; KIDNEY; LUNG; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SKELETAL MUSCLE; TESTIS; UPREGULATION;

EID: 0041760905     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00457-X     Document Type: Article

References (31)

1. Paul M., Stoll M., Kreutz R., Fernandez A.M. The cellular basis of angiotensin converting enzyme mRNA expression in rat heart. Basic Res. Cardiol. 91(Suppl. 2):1996;57-63.
2. Hagaman J.R., Moyer J.S., Bachman E.S., Sibony M., Magyar X., Welch J.E., Smithies O., Krege J.H., O'Brien D.A. Angiotensin-converting enzyme and male fertility. Proc. Natl. Acad. Sci. U.S.A. 95:1998;2552-2557.
3. Kang N., Walther T., Tian X.L., Bohlender J., Fukamizu A., Ganten D., Bader M. Reduced hypertension-induced end-organ damage in mice lacking cardiac and renal angiotensinogen synthesis. J. Mol. Med. 80:2002;359-366.
4. Jeunemaitre X., Lifton R.P., Hunt S.C., Williams R.R., Lalouel J.M. Absence of linkage between the angiotensin converting enzyme locus and human essential hypertension. Nat. Genet. 1:1992;72-75.
5. Corvol P., Michaud A., Soubrier F., Williams T.A. Recent advances in knowledge of the structure and function of the angiotensin I converting enzyme. J. Hypertens. Suppl. 13(Suppl. 3):1995;3-10.
6. Soubrier F., Alhenc-Gelas F., Hubert C., Allegrini J., John M., Tregear G., Corvol P. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc. Natl. Acad. Sci. U.S.A. 85:1988;9386-9390.
7. Beldent V., Michaud A., Wei L., Chauvet M.T., Corvol P. Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site. J. Biol. Chem. 268:1993;26428-26434.
8. Howard T.E., Shai S.Y., Langford K.G., Martin B.M., Bernstein K.E. Transcription of testicular angiotensin-converting enzyme (ACE) is initiated within the 12th intron of the somatic ACE gene. Mol. Cell Biol. 10:1990;4294-4302.
9. Deddish P.A., Wang J., Michel B., Morris P.W., Davidson N.O., Skidgel R.A., Erdos E.G. Naturally occurring active N-domain of human angiotensin I-converting enzyme. Proc. Natl. Acad. Sci. U.S.A. 91:1994;7807-7811.
10. Ehlers M.R., Chen Y.N., Riordan J.F. Spontaneous solubilization of membrane-bound human testis angiotensin-converting enzyme expressed in Chinese hamster ovary cells. Proc. Natl. Acad. Sci. U.S.A. 88:1991;1009-1013.
11. Woodman Z.L., Oppong S.Y., Cook S., Hooper N.M., Schwager S.L., Brandt W.F., Ehlers M.R., Sturrock E.D. Shedding of somatic angiotensin-converting enzyme (ACE) is inefficient compared with testis ACE despite cleavage at identical stalk sites. Biochem. J. 347(Pt 3):2000;711-718.
12. Hubert C., Houot A.M., Corvol P., Soubrier F. Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J. Biol. Chem. 266:1991;15377-15383.
13. Krege J.H., John S.W., Langenbach L.L., Hodgin J.B., Hagaman X., Bachman E.S., Jennette J.C., O'Brien D.A., Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 375:1995;146-148.
14. Esther C.R., Marino E.M., Howard T.E., Machaud A., Corvol P., Capecchi M.R., Bernstein K.E. The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J. Clin. Invest. 99:1997;2375-2385.
15. Kessler S.P., Rowe T.M., Gomos J.B., Kessler P.M., Sen G.C. Physiological non-equivalence of the two isoforms of angiotensin-converting enzyme. J. Biol. Chem. 275:2000;26259-26264.
16. Kessler S.P., Gomos J.B., Scheidemantel T.S., Rowe T.M., Smith H.L., Sen G.C. The germinal isozyme of angiotensin-converting enzyme can substitute for the somatic isozyme in maintaining normal renal structure and functions. J. Biol. Chem. 277:2002;4271-4276.
17. Tian X.L., Costerousse O., Urata H., Franz W.M., Paul M. A new transgenic rat model overexpressing human angiotensin-converting enzyme in the heart. Hypertension. 28:1996;70.
18. Ramaraj P., Kessler S.P. Colmenares C and Sen GC, selective restoration of male fertility in mice lacking angiotensin-converting enzymes by sperm-specific expression of the testicular isozyme. J. Clin. Invest. 102:1998;371-378.
19. Costerousse O., Jaspard E., Wei L., Corvol P., Alhenc X. The angiotensin I-converting enzyme (kininase II): molecular organization and regulation of its expression in humans. J. Cardiovasc. Pharmacol. 20(Suppl. 9):1992;S10-S15.
20. Beldent V., Michaud A., Bonnefoy C., Chauvet M.T., Corvol P. Cell surface localization of proteolysis of human endothelial angiotensin I-converting enzyme. Effect of the amino-terminal domain in the solubilization process. J. Biol. Chem. 270:1995;28962-28969.
21. Pang S., Chubb A.J., Schwager S.L., Ehlers M.R., Sturrock E.D., Hooper N.M. Roles of the juxtamembrane and extracellular domains of angiotensin-converting enzyme in ectodomain shedding. Biochem. J. 358:2001;185-192.
22. Sugimura K., Tian X.L., Hoffmann S., Ganten D., Bader M. Alternative splicing of the mRNA coding for the human endothelial angiotensin-converting enzyme: a new mechanism for solubilization. Biochem. Biophys. Res. Commun. 247:1998;466-472.
23. Langford K.G., Shai S.Y., Howard T.E., Kovac M.J., Overbeek P.A., Bernstein K.E. Transgenic mice demonstrate a testis-specific promoter for angiotensin-converting enzyme. J. Biol. Chem. 266:1991;15559-15562.
24. Koike G., Krieger J.E., Jacob H.J., Mukoyama M., Pratt R.E., Dzau V.J. Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. Biochem. Biophys. Res. Commun. 198:1994;380-386.
25. Ehlers M.R., Fox E.A., Strydom D.J., Riordan J.F. Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme. Proc. Natl. Acad. Sci. U.S.A. 86:1989;7741-7745.
26. Yamori Y. Spontaneously hypertensive rats. Hypertension. 9:1987;I-13-I-14.
27. Gray S.D. Spontaneous hypertension in the neonatal rat. Clin. Exp. Hypertens. A. 6:1984;755-781.
28. Hirsch A.T., Talsness C.E., Schunkert H., Paul M., Dzau V.J. Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ. Res. 69:1991;475-482.
29. Paul M., Pinto Y.M., Schunkert H., Ganten D., Bohm M. Activation of the renin-angiotensin system in heart failure and hypertrophy-studies in human hearts and transgenic rats. Eur. Heart J. 15(Suppl. D):1994;63-67.
30. Paul M., Stock P., Langheinrich M., Liefeldt L., Schonfelder G., Bohm M. Role of the cardiac renin-angiotensin system in human heart failure. Adv. Exp. Med. Biol. 377:1995;279-283.
31. Heymes C., Swynghedauw B., Chevalier B. Activation of angiotensinogen and angiotensin-converting enzyme gene expression in the left ventricle of senescent rats. Circulation. 90:1994;1328-1333.