Formation of platelet-leukocyte aggregates in inflammatory bowel disease

Inflammatory Bowel Diseases

Volumn 10, Issue 4, 2004, Pages 361-372

  Irving, Peter M ^a   Macey, Marion G ^b   Shah, Urooj ^b   Webb, Lee ^b   Langmead, Louise ^a   Rampton, David S ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b NATIONAL HEALTH SERVICE   (United Kingdom)

^c ROYAL LONDON HOSPITAL   (United Kingdom)

Author keywords

Inflammatory arthropathy controls; Inflammatory bowel disease; Platelet leukocyte aggregates; Ulcerative colitis

Indexed keywords

5 ACETAMIDOSALICYLIC ACID; 6 MERCAPTOPURINE DERIVATIVE; ADENOSINE; AMINOSALICYLIC ACID; ANTICOAGULANT AGENT; AZATHIOPRINE; CD45 ANTIGEN; CITRIC ACID; CORTICOSTEROID; CYCLOSPORIN; DIPYRIDAMOLE; EDETIC ACID; IMMUNOGLOBULIN ANTIBODY; L SELECTIN; MERCAPTOPURINE; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PADGEM PROTEIN; STEROID; THEOPHYLLINE;

ADULT; AGED; ARTHROPATHY; ARTICLE; AUTOANALYZER; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ACTIVITY; ENTERITIS; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HEMATOLOGY; HUMAN; HUMAN CELL; INCUBATION TIME; LEUKOCYTE ACTIVATION; LEUKOCYTE AGGREGATION; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STATISTICAL ANALYSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT;

ADOLESCENT; ADULT; AGED; CASE-CONTROL STUDIES; CELL AGGREGATION; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATORY BOWEL DISEASES; L-SELECTIN; LEUKOCYTES; MIDDLE AGED; P-SELECTIN; PLATELET AGGREGATION;

EID: 3543127813     PISSN: 10780998     EISSN: None     Source Type: Journal    
DOI: 10.1097/00054725-200407000-00007     Document Type: Article

References (68)

1. Page CP. Platelets as inflammatory cells, Immunopharmacology. 1989; 17:51-59.
2. Morowitz DA, Allen LW, Kirsner JB. Thrombocytosis in chronic inflammatory bowel disease. Ann Intern Med. 1968;68:1013-1021.
3. Harries AD, Fitzsimons E, Fifield R, et al. Platelet count: a simple measure of activity in Crohn's disease. Br Med J (Clin Res Ed). 1983; 286(6376):1476.
4. Collins CE, Cahill MR, Newland AC, et al. Platelets circulate in an activated state in inflammatory bowel disease. Gastroenterology. 1994;106: 840-845.
5. Wakefield AJ, Sawyerr AM, Dhillon AP, et al. Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction. Lancet. 1989;2:1057-1062.
6. Thornton M, Solomon MJ. Crohn's disease: in defense of a microvascular aetiology. Int J Colorectal Dis. 2002; 17:287-297.
7. Evangelista V, Rajtar G, de Gaetano G, et al. Platelet activation by fMLP-stimulated polymorphonuclear leukocytes: the activity of cathepsin G is not prevented by antiproteinases. Blood. 1991;77:2379-2388.
8. Peters MJ, Dixon G, Kotowicz KT, et al. Circulating platelet-neutrophil complexes represent a subpopulation of activated neutrophils primed for adhesion, phagocytosis and intracellular killing. Br J Haematol. 1999; 106:391-399.
9. Celi A, Pellegrini G, Lorenzet R, et al. P-Selectin Induces the Expression of Tissue Factor on Monocytes. PNAS. 1994;91:8767-8771.
10. Ott I, Neumann FJ, Gawaz M, et al. Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina. Circulation. 1996;94:1239-1246.
11. Peters MJ, Heyderman RS, Hatch DJ, et al. Investigation of platelet-neutrophil interactions in whole blood by flow cytometry. J Immunol Methods. 1997;209:125-135.
12. Li N, Goodall AH, Hjemdahl P. Efficient flow cytometric assay for platelet-leukocyte aggregates in whole blood using fluorescence signal triggering. Cytometry. 1999;35:154-161.
13. Kaplar M, Kappelmayer J, Kiss A, et al. Increased leukocyte-platelet adhesion in chronic myeloproliferative disorders with high platelet counts. Platelets. 2000;11:183-184.
14. Furman MI, Benoit SE, Barnard MR, et al. Increased platelet reactivity and circulating monocyte-platelet aggregates in patients with stable coronary artery disease. J Am Coll Cardiol. 1998;31:352-358.
15. Furman MI, Barnard MR, Krueger LA, et al. Circulating monocyte-platelet aggregates are an early marker of acute myocardial infarction. J Am Coll Cardiol. 2001;38:1002-1006.
16. Joseph JE, Harrison P, Mackie JM, et al. Increased circulating Platelet-leucocyte complexes and platelet activation in patients with antiphospholipid syndrome, systemic lupus erythematosus and rheumatoid arthritis. Br J Haematol. 2001;115:451-459.
17. Gawaz M, Fateh-Moghadam S, Pilz G, et al. Platelet activation and interaction with leucocytes in patients with sepsis or multiple organ failure. Eur J Clin Invest. 1995;25:843-851.
18. Lehr HA, Weyrich AS, Saetzler RK, et al. Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. J Clin Invest. 1997;99:2358-2364.
19. Li N, Wallen NH, Hjemdahl P. Evidence for prothrombotic effects of exercise and limited protection by aspirin. Circulation. 1999; 100:1374-1379.
20. Rinder CS, Bonan JL, Rinder HM, et al. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood. 1992;79:1201-1205.
21. Gawaz MP, Mujais SK, Schmidt B, et al. Platelet-leukocyte aggregation during hemodialysis. Kidney Int. 1994;46:489-495.
22. Mickelson JK, Lakkis NM, Villarreal-Levy G, et al. Leukocyte activation with platelet adhesion after coronary angioplasty: a mechanism for recurrent disease? J Am Coll Cardiol. 1996;28:345-353.
23. Macey M, Azam U, McCarthy D, et al. Evaluation of the Anticoagulants EDTA and Citrate, Theophylline, Adenosine, and Dipyridamole (CTAD) for Assessing Platelet Activation on the ADVIA 120 Hematology System. Clin Chem. 2002;48:891-899.
24. Rinder HM, Bonan JL, Rinder CS, et al. Dynamics of leukocyte-platelet adhesion in whole blood. Blood. 1991;78:1730-1737.
25. Macey MG, Carty E, Webb L, et al. Use of mean platelet component to measure platelet activation on the ADVIA 120 haematology system. Cytometry. 1999;38:250-255.
26. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet. 1980;1:514.
27. Walmsley RS, Ayres RC, Pounder RE, et al. A simple clinical colitis activity index. Gut. 1998:43:29-32.
28. Zelmanovic D, Colella GM, Hetherington EJ et al., inventors. Automated method and device for identifying and quantifying platelets and for determining platelet activation state using whole blood samples. United States Patent 5,817,519. 1998.
29. Ahnadi CE, Chapman ES, Okrongly D, et al. Evaluation of platelet activation in patients with chest pain by the ADVIA 120 haematology system. XIIIth International Symposium on Technical Innovations in Laboratory Haematology (Banff, Canada) 41. 2000.
30. Macey M, McCarthy D, Azam U, et al. Ethylenediaminetetraacetic acid-citrate-theophylline-dipyridamole (EDTA-CTAD) a novel anticoagulant for the flow cytometric assessment of platelet and neutrophil activation ex vivo in whole blood. Cytometry. 2003;51B:30-40.
31. Perneger TV. What's wrong with Bonferroni adjustments. BMJ. 1998; 316:1236-1238.
32. Clinical Chemistry. Theory, analysis, correlation. In: Kaplan LA, Amadeo JP, editors. St Louis: Mosby, 1996:347.
33. Daig R, Andus T, Aschenbrenner E, et al. Increased interleukin 8 expression in the colon mucosa of patients with inflammatory bowel disease. Gut. 1996;38:216-222.
34. McAlindon ME, Hawkey CJ, Mahida YR. Expression of interleukin 1 beta and interleukin 1 beta converting enzyme by intestinal macrophages in health and inflammatory bowel disease. Gut. 1998;42:214-219.
35. Saverymuttu SH, Lavender JP, Hodgson HJ, et al. Assessment of disease activity in inflammatory bowel disease: a new approach using 111 In granulocyte scanning. Br Med J (Clin Res Ed). 1983;287(6407): 1751-1753.
36. Neumann FJ, Marx N, Gawaz M, et al. Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets. Circulation. 1997;95:2387-2394.
37. Kirton CM, Nash GB. Activated platelets adherent to an intact endothelial cell monolayer bind flowing neutrophils and enable them to transfer to the endothelial surface. Journal of Laboratory & Clinical Medicine. 2000; 136:303-313.
38. Diacovo TG, Roth SJ, Buccola JM, et al. Neutrophil rolling, arrest, and transmigration across activated, surface-adherent platelets via sequential action of P-selectin and the beta 2-integrin CD11b/CD18. Blood. 1996; 88:146-157.
39. Kurose I, Pothoulakis C, LaMont JT, et al. Clostridium difficile toxin A-induced microvascular dysfunction. Role of histamine. J Clin Invest. 1994;94:1919-1926.
40. Kurose I, Granger DN, Evans DJ Jr, et al. Helicobacter pylori-induced microvascular protein leakage in rats: role of neutrophils, mast cells, and platelets. Gastroenterology. 1994; 107:70-79.
41. Carty E, MacEy M, Rampton DS. Inhibition of platelet activation by 5-aminosalicylic acid in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics. 2000;14:1169-1179.
42. Knight CJ, Panesar M, Wright C, et al. Altered platelet function detected by flow cytometry. Effects of coronary artery disease and age. Arteriosclerosis. Thrombosis & Vascular Biology. 1997;17:2044-2053.
43. Collins CE, Cahill MR, Rampton DS. Paradoxical association between increased platelet activation and reduced platelet volume in Crohn's disease. Gut. 1993;34:S63.
44. Jaremo P, Sandberg-Gertzen H. Platelet density and size in inflammatory bowel disease. Thrombosis & Haemostasis. 1996; 75:560-561.
45. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: a useful marker of inflammatory bowel disease activity. Am J Gastroenterol. 2001;96:776-781.
46. Palecanda A, Walcheck B, Bishop DK, et al. Rapid activation-independent shedding of leukocyte L-selectin induced by cross-linking of the surface antigen. Eur J Immunol. 1992;22:1279-1286.
47. Bargatze RF, Kurk S, Butcher EC, et al. Neutrophils roll on adherent neutrophils bound to cytokine-induced endothelial cells via L-selectin on the rolling cells. J Exp Med. 1994;180:1785-1792.
48. Seidelin JB, Vainer B, Horn T, et al. Circulating L-selectin levels and endothelial CD34 expression in inflammatory bowel disease. Am J Gastroenterol. 1998;93:1854-1859.
49. Patiar S, Slade D, Kirkpatrick U, et al. Smoking causes a dose-dependent increase in granulocyte bound L-selectin. Thromb Res. 2002;106:1-6.
50. Ryder MI, Fujitaki R, Lebus S, et al. Alterations of neutrophil L-selection and CD18 expression by tobacco smoke: implications for periodontal diseases. J Periodontal Res. 1998;33:359-368.
51. Noguera A, Batle S, Miralles C, et al. Enhanced neutrophil response in chronic obstructive pulmonary disease. Thorax. 2001;56:432-437.
52. Pitzer JE, Del-Zoppo GJ, Schmid-Schonbein GW. Neutrophil activation in smokers. Biorheology. 1996;33:45-58.
53. Li N, Goodall AH, Hjemdahl P. A sensitive flow cytometric assay for circulating platelet-leucocyte aggregates. Br J Haematol. 1997;99:808-816.
54. Webberley MJ, Hart MT, Melikian V. Thromboembolism in inflammatory bowel disease: role of platelets. Gut. 1993;34:247-251.
55. Tschoepe D, Schwippert B, Schumacher B. Increased P-selectin expression on platelets from capillary whole blood of patients with Crohn's disease. Gastroenterology. 1993;104:A793.
56. Collins CE, Rampton DS, Rogers J, et al. Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. European Journal of Gastroenterology & Hepatology. 1997;9: 1213-1217.
57. Eliakim R, Karmeli F, Razin E, et al. Role of platelet-activating factor in ulcerative colitis. Enhanced production during active disease and inhibition by sulfasalazine and prednisolone. Gastroenterology. 1988;95:1167-1172.
58. Rachmilewitz D, Ligumsky M, Haimovitz A, et al. Prostanoid synthesis by cultured peripheral blood mononuclear cells in inflammatory diseases of the bowel. Gastroenterology. 1982;82:673-679.
59. Elstad MR, McIntyre TM, Prescott SM, et al. The interaction of leukocytes with platelets in blood coagulation. Curr Opin Hematol. 1995;2: 47-54.
60. de Gaetano G, Cerletti C, Evangelista V. Recent advances in platelet-polymorphonuclear leukocyte interaction. Haemostasis. 1999;29:41-49.
61. Larsen E, Celi A, Gilbert GE, et al. PADGEM protein: a receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell. 1989;59:305-312.
62. Hamburger SA, McEver RP. GMP-140 mediates adhesion of stimulated platelets to neutrophils. Blood. 1990;75:550- 554.
63. Moore KL, Stults NL, Diaz S, et al. Identification of a specific glycoprotein ligand for P-selectin (CD62) on myeloid cells. J Cell Biol. 1992;118: 445-456.
64. Sako D, Chang XJ, Barone KM, et al. Expression cloning of a functional glycoprotein ligand for P-selectin. Cell. 1993;75:1179-1186.
65. Moore KL, Patel KD, Bruehl RE, et al. P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J Cell Biol. 1995; 128:661-671.
66. Konstantopoulos K, Neelamegham S, Burns AR, et al. Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and beta2-integrin. Circulation. 1998;98:873-882.
67. Rinder HM, Tracey JL, Rinder CS, et al. Neutrophil but not monocyte activation inhibits P-selectin-mediated platelet adhesion. Thrombosis & Haemostasis. 1994;72:750-756.
68. Thomas G, Skrinska VA, Lucas FV. The influence of glutathione and other thiols on human platelet aggregation. Thromb Res. 1986;44:859-866.