Quantification of mephenytoin and its metabolites 4′- hydroxymephenytoin and nirvanol in human urine using a simple sample processing method

Rapid Communications in Mass Spectrometry

Volumn 18, Issue 15, 2004, Pages 1675-1680

  Klaassen, Tobias ^a   Kasel, Dirk ^a   Harlfinger, Stefanie ^a   Fuhr, Uwe ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BODY FLUIDS; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

CYTOCHROME P450 ENZYMES; HUMAN URINE; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTIFICATIONS; PHENOTYPING; PROCESSING METHOD; SAMPLE EXTRACTION; SAMPLE PROCESSING; SIMPLE++; THERMO ELECTRONS;

METABOLITES;

4' HYDROXYMEPHENYTOIN; ANTICONVULSIVE AGENT; DRUG METABOLITE; MEPHENYTOIN; NORMEPHENYTOIN;

ANALYTIC METHOD; ARTICLE; CALIBRATION; CHEMICAL STRUCTURE; CHROMATOGRAPHY; DRUG METABOLISM; DRUG URINE LEVEL; HUMAN; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NORMAL HUMAN; PHENOTYPE; QUALITY CONTROL; STANDARD; STEREOCHEMISTRY;

EID: 3543082669     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1539     Document Type: Article

References (21)

1. Veronese ME, McManus ME, Laupattarakasem P, Miners JO, Birkett DJ. Drug Metab. Dispos. 1990; 18: 365.
2. He N, Yan FX, Huang SL, Wang W, Xiao ZS, Liu ZQ, Zhou HH. Eur. J. Clin. Pharmacol. 2002; 58: 15.
3. Wedlund PJ, Sweetman BJ, McAllister CB, Branch RA, Wilkinson GR. J. Chromatogr. B Technol. Biomed. Life Sci. 1984; 307: 121.
4. Küpfer A, Preisig R. Eur. J. Clin. Pharmacol. 1984; 26: 753.
5. Wedlund PJ, Aslanian WS, Jacqz E, McAllister CB, Branch RA, Wilkinson GR. J. Pharmacol. Exp. Ther. 1985; 234: 662.
6. Ekins S, Vandenbranden M, Ring BJ, Gillespie JS, Yang TJ, Gelboin H, Wrighton S. J. Pharmacol. Exp. Ther. 1998; 286: 1253.
7. Tybring G, Nordin J, Bergman T, Bertilsson L. Pharmacogenetics 1997; 7: 355.
8. Tamminga WJ, Wemer J, Oosterhuis B, Wieling J, Touw DJ, de Zeeuw RA, de Leij LF, Jonkman JH. Br. J. Clin. Pharmacol. 2001; 51: 471.
9. Ko JW, Desta Z, Flockhart DA. Drug Metab. Dispos. 1998; 26: 775.
10. Yao TW, Zeng S, Wang TW, Chen SQ. Biomed. Chromatogr. 2001; 15: 9.
11. Nolin TD, Frye RF. J. Chromatogr. B Technol. Biomed. Life Sci. 2003; 783: 265.
12. Xie HG, Huang SL, Zhou HH. J. Chromatogr. B Biomed. Appl. 1995; 668: 125.
13. Tanaka M, Kato K, Sudo K, Hakusui H, Ohkubo T, Sugawara K, Kaneko S, Otani K, Chiba K, Ishizaki T. J. Chromatogr. B Biomed. Appl. 1996; 676: 87.
14. Dierks EA, Stams KR, Lim HK, Cornelius G, Zhang H, Ball SE. Drug Metab. Dispos. 2001; 29: 23.
15. Zhang T, Zhu Y, Gunaratna C. J. Chromatogr. B Technol. Biomed. Life Sci. 2002; 780: 371.
16. Scott RJ, Palmer J, Lewis IAS, Pleasance S. Rapid Commun. Mass Spectrom. 1999; 13: 2305.
17. Shah VP, Midha KK, Findlay JW, Hill HM, Hulse JD, McGilveray IJ, McKay G, Miller KJ, Patnaik RN, Powell ML, Tonelli A, Viswanathan CT, Yacobi A. Pharm. Res. 2000; 17: 1551.
18. CPMP/ICH/381/95, EEC Note for Guidance on Validation of Analytical Procedures: Definitions and Terminology, London, 1994.
19. CPMP/ICH/281/95, EEC Note for Guidance, Validation of Analytical Procedures: Methodology. London, 1996.
20. U.S. Department of Health and Human Services Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation, US Department of Health and Human Services: Beltsville, MD, 2001.
21. Jetter A, Kinzig-Schippers M, Skott A, Lazar A, Tomalik-Scharte D, Kirchheiner J, Walchner-Bonjean M, Hering U, Jakob V, Rodamer M, Jabrane W, Kasel D, Brockmöller J, Fuhr U, Sörgel F. Eur. J. Clin. Pharmacol. 2004; 60: 165.