Engineered RNase P ribozymes increase their cleavage activities and efficacies in inhibiting viral gene expression in cells by enhancing the rate of cleavage and binding of the target mRNA

Journal of Biological Chemistry

Volumn 279, Issue 31, 2004, Pages 32063-32070

  Zou, Hua ^a   Lee, Jarone ^a   Kilani, Ahmed F ^a   Kim, Kihoon ^a   Trang, Phong ^a   Kim, Joseph ^a   Liu, Fenyong ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; ESCHERICHIA COLI; RNA;

NUCLEOTIDE; RIBOZYMES;

GENES;

ENZYME VARIANT; MESSENGER RNA; RIBONUCLEASE P; RIBOZYME; THYMIDINE KINASE;

ARTICLE; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; ESCHERICHIA COLI; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE TARGETING; HERPES SIMPLEX VIRUS 1; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RNA CLEAVAGE; VIRUS GENE;

BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CATALYSIS; ESCHERICHIA COLI; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PLASMIDS; POINT MUTATION; PROTEIN BINDING; RETROVIRIDAE; RIBONUCLEASE P; RNA; RNA, CATALYTIC; RNA, MESSENGER; SIMPLEXVIRUS; THYMIDINE KINASE; TIME FACTORS; VIRAL PROTEINS;

ESCHERICHIA COLI; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 3543031614     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M403059200     Document Type: Article

References (46)

1. Scherer, L., and Rossi, J. (2003) Nat. Biotechnol. 21, 1457-1465
2. Zamecnik, P. C., and Stephenson, M. L. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 280-284
3. Stein, C. A., and Cheng, Y. C. (1993) Science 261, 1004-1012
4. Wong-Staal, F., Poeschla, E. M., and Looney, D. J. (1998) Hum. Gene Ther. 9, 2407-2425
5. Sarver, N., Cantin, E. M., Chang, P. S., Zaia, J. A., Ladne, P. A., Stephens, D. A., and Rossi, J. J. (1990) Science 247, 1222-1225
6. zu Putlitz, J., Yu, Q., Burke, J. M., and Wands, J. R. (1999) J. Virol. 73, 5381-5387
7. Yu, M., Ojwang, J., Yamada, O., Hampel, A., Rapapport, J., Looney, D., and Wong-Staal, F. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 6340-6344
8. Lan, N., Howrey, R. P., Lee, S. W., Smith, C. A., and Sullenger, B. A. (1998) Science 280, 1593-1596
9. Altman, S., and Kirsebom, L. A. (1999) in The RNA World (Gesteland, R. F., Cech, T. R., and Atkins, J. F., eds) 2nd Ed., pp. 351-380, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
10. Frank, D. N., and Pace, N. R. (1998) Annu. Rev. Biochem. 67, 153-180
11. Guerrier-Takada, C., Gardiner, K., Marsh, T., Pace, N., and Altman, S. (1983) Cell 35, 849-857
12. Gopalan, V., Vioque, A., and Altman, S. (2002) J. Biol. Chem. 277, 6759-6762
13. Forster, A. C., and Altman, S. (1990) Science 249, 783-786
14. Frank, D., Harris, M., and Pace, N. R. (1994) Biochemistry 33, 10800-10808
15. Liu, F., and Altman, S. (1995) Genes Dev. 9, 471-480
16. Trang, P., Hsu, A. W., and Liu, F. (1999) Nucleic Acids Res. 27, 4590-4597
17. Hsu, A. W., Kilani, A. F., Liou, K., Lee, J., and Liu, F. (2000) Nucleic Acids Res. 28, 3105-3116
18. Kilani, A. F., and Liu, F. (1999) RNA (N. Y.) 5, 1235-1247
19. Kilani, A. F., Trang, P., Jo, S., Hsu, A., Kim, J., Nepomuceno, E., Liou, K., and Liu, F. (2000) J. Biol. Chem. 275, 10611-10622
20. Trang, P., Kilani, A. F., Kim, J., and Liu, F. (2000) J. Mol. Biol. 301, 817-826
21. Trang, P., Lee, M., Nepomuceno, E., Kim, J., Zhu, H., and Liu, F. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 5812-5817
22. Kim, J. J., Kilani, A. F., Zhan, X., Altman, S., and Liu, F. (1997) RNA (N. Y.) 3, 613-623
23. Miller, A. D., and Rosman, G. J. (1989) BioTechniques 7, 980-990
24. Liu, F., and Roizman, B. (1991) J. Virol. 65, 5149-5156
25. Kawa, D., Wang, J., Yuan, Y., and Liu, F. (1998) RNA (N. Y.) 4, 1397-1406
26. Fedor, M. J., and Uhlenbeck, O. C. (1992) Biochemistry 31, 12042-12054
27. Smith, D., and Pace, N. R. (1993) Biochemistry 32, 5273-5281
28. Smith, D., Burgin, A. B., Haas, E. S., and Pace, N. R. (1992) J. Biol. Chem. 267, 2429-2436
29. Loria, A., and Pan, T. (1999) Biochemistry 38, 8612-8620
30. Kurz, J. C., and Fierke, C. A. (2000) Curr. Opin. Chem. Biol. 4, 553-558
31. Pyle, A. M., McSwiggen, J. A., and Cech, T. R. (1990) Proc. Natl. Acad. Sci. 87, 8187-8191
32. Area, M., and Igel, A. H. (1990) Genes Dev. 4, 2132-2145
33. Zaug, A. J., and Cech, T. R. (1995) RNA (N. Y.) 1, 363-374
34. Bertrand, E., Castanotto, D., Zhou, C., Carbonnelle, C., Lee, N. S., Good, P., Chatteijee, S., Grange, T., Pictet, R., Kohn, D., Engelke, D., and Rossi, J. J. (1997) RNA (N. Y.) 3, 75-88
35. Plehn-Dujowich, D., and Altman, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 7327-7332
36. Yuan, Y., Hwang, E., and Altman, S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 8006-8010
37. Das, G., Henning, D., Wright, D., and Reddy, R. (1988) EMBO J. 7, 503-512
38. Good, P. D., Krikos, A. J., Li, S. X., Bertrand, E., Lee, N. S., Giver, L., Ellington, A., Zaia, J. A., Rossi, J. J., and Engelke, D. R. (1997) Gene Ther. 4, 45-54
39. Danes, O., and Mulligan, R. C. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 6460-6464
40. Roizman, B., and Knipe, D. M. (2001) in Fields Virology (Knipe, D. M., and Howley, P. M., eds) Vol. 2, 3rd Ed., pp. 2399-2460, Lippincott-Williams & Wilkins, Philadelphia, PA
41. Donahue, C. P., and Fedor, M. J. (1997) RNA (N. Y.) 3, 961-973
42. Fedor, M. J. (2000) J. Mol. Biol. 297, 269-291
43. Chen, J. L., Nolan, J. M., Harris, M. E., and Pace, N. R. (1998) EMBO J. 17, 1515-1525
44. Massire, C., Jaeger, L., and Westhof, E. (1998) J. Mol. Biol. 279, 773-793
45. Haas, E. S., and Brown, J. W. (1998) Nucleic Acids Res. 26, 4093-4099
46. Haas, E. S., Brown, J. W., Pitulle, C., and Pace, N. R. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 2527-2531