Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines

Farmaco

Volumn 55, Issue 4, 2000, Pages 287-292

  Abdel Gawad, Soad M ^a   El Gaby, Mohamed S A ^a   Ghorab, Moustafa M ^b  

^a Assiut Branch   (Egypt)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

Antifungal activity; Pyranothiazoloquinazoline; Thiazoloquinazolines

Indexed keywords

ANTIFUNGAL AGENT; PYRANO[2',3':4,5]THIAZOLO[2,3 B]QUINAZOLINE DERIVATIVE; PYRAZOLO[2',3':4,5]THIAZOLO[2,3 B]QUINAZOLINE DERIVATIVE; PYRIDO[2',3':4,5]THIAZOLO[2,3 B]QUINAZOLINE DERIVATIVE; TIOCONAZOLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS FLAVUS; ASPERGILLUS OCHRACEUS; CANDIDA ALBICANS; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; PENICILLIUM CHRYSOGENUM; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTIFUNGAL AGENTS; ASPERGILLUS FLAVUS; ASPERGILLUS OCHRACEUS; CANDIDA ALBICANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PENICILLIUM CHRYSOGENUM; PYRANS; PYRAZOLES; PYRIDINES; QUINAZOLINES; THIAZOLES;

EID: 0033838080     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(00)00042-2     Document Type: Article

References (21)

1. Honda G., Tabata M., Tsuda M. The antimicrobial specificity of tryptanthrin. Plant. Med. 37:1979;172.
2. N.B. Chapman, G.M. Gibson, F.G. Mann, Synthetic antimalarials. Part XVI. 4-dialkylaminoalkylaminoquinazolines. Variation of substituents in 6- and 7- positions, J. Chem. Soc. (1947) 890.
3. Abdel-Hamide S.G., El-Hakim A.E., El-Helby A.A. Synthesis of 2-[1-(5-ethyl-5-phenyl)barbituryl]methylcarbonylthioquinazoline-4-one for hypnotic and anticonvulsant activities. Az. J. Pharm. Sci. 17:1996;35.
4. G.E. Hardtmann, H. Ott, Stimulant and antidepressant 4-(substituted amino)quinazolines, U.S. Patent 3470182 (1969) [Chem. Abstr. 72 (1970) 90 502d].
5. N.B. Chapman, K. Clarke, K. Wilson, Synthesis of N,N-dialkyl-N′-arylalkyl-N-4-cinnolinyl (or 9-fluorenyl or 6-methyl-3-pyridazinyl or 1-phthalazinyl or 2-quinoxalinyl)ethylenediamines of potential pharmacological interest, J. Chem. Soc. (1963) 2256.
6. A.J. Barker, Preparation of 4-anilinoquinazolines as anticancer agents, Eur. Patent 635498 (1995) [Chem. Abstr. 122 (1995) 214 099a].
7. Bekhit A.A., Khalil M.A. Non-steroidal antiinflammatory agents: synthesis of novel benzopyrazolyl, benzoxazolyl and quinazolinyl derivatives of 4(3H)-quinazolinones. Pharmazie. 53:1998;539.
8. Habib N.S., El-Hawash S.A. Synthesis and antimicrobial testing of thiazolinyl-, thiazolidinonylquinoxalines and 1,2,4-triazolo[4,3-a]quinoxalines. Pharmazie. 52:1997;594.
9. Shukla J.S., Shukla R. Synthesis of 4-(5-substituted-arylidine-4-thiazolidinone-2-thione)-6,8-substituted quinazolines as potential anthelmintic agents. J. Indian Chem. Soc. 66:1989;209.
10. Malesic M., Krbovcic A., Golobio A., Golic L., Stanovnik B. The synthesis and transformation of some 3-thiocarbamoylthiazolidines. J. Heterocyclic Chem. 34:1997;43.
11. McDonald L.A., Foster M.P., Phillips D.R., Ireland C.M. Towicyclamides A and B, new cyclic peptides from the ascidian lissoclinum patella: studies on the solution and solid state conformations. J. Org. Chem. 57:1992;4616.
12. Sarac S., Yarim M., Ertan M., Boydag S., Erol K. Synthesis, chemical and pharmacological properties of some 4-aryl-1,2,3,4,5,6,7,8-octahydroquinazoline-2,5-diones. Pharmazie. 53:1997;91.
13. Tozkoparan B., Akgun H., Ertan M., Rubsemann K. Condensed heterocyclic compounds: synthesis and antiinflammatory activity of novel thiazolo[3,2-a]pyrimidines. Arch. Pharm. (Weinheim). 321:1998;201.
14. Daboun H.A., AbdFattah A.M., Abdaziz M.A. Reactions with thiazolo[3,2-a]benzimidazol-3-one derivatives: a novel synthesis of pyrano- and pyrido[2,3:4′,5]thiazolo[2,3-a]benzimidazole derivatives. Egypt J. Chem. 27:1984;435. [Chem. Abstr. 106 (1987) 102 156e].
15. E.T. McCarthy, D.V. Tyndall, M.J. Meegan, A new synthesis of pyrido[3,2-a]benzothiazines, J. Chem. Res. (S) (1988) 145; J. Chem. Res. (M) (1988) 1332.
16. E.T. McCarthy, D.V. Tyndall, M.J. Meegan, A new synthesis of pyrido[3,2-a]benzothiazines, J. Chem. Res. (S) (1988) 145; J. Chem. Res. (M) (1988) 1332.
17. Dwivedi D., Tiwari N. Synthesis of some 1-aroyl-3-methyl-4-substituted phenyl-6-imino-4,7-dihydro-1,3-thiazino[5,4-d]pyrazoles as pesticides. J. Indian Chem. Soc. 68:1991;515.
18. Kabli R.A., Khalaf A.A., Zimaity M.T., Khalil A.M., Kaddah A.M., Al-Rifaie H.A. Synthesis of a new series of furyl and thienyl substituted pyrazolines starting with furyl and thienyl chalcones. J. Indian Chem. Soc. 68:1991;47.
19. Carrod L.P., Grady F.D. Antibiotic and Chemotherapy. third ed. 1972;477 Churchill Livingstone, Edinburgh.
20. Cremer A. Antibiotic Sensitivity and Assay Tests. fourth ed. 1980;521 Butterworth, London.
21. Courvalin P. Interpretive reading of antimicrobial susceptibility tests. Am. Soc. Microbiol. News. 58:1992;368-375.