Tryptanthrin content in Isatis tinctoria leaves - A comparative study of selected strains and post-harvest treatments

Planta Medica

Volumn 70, Issue 7, 2004, Pages 642-645

  Oberthür, Christine ^a   Hamburger, Matthias ^a,b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Anti inflammatory; Brassicaceae; ESI LC MS; Isatis tinctoria; Isotope dilution; Post harvest modification; Tryptanthrin; Woad

Indexed keywords

ANTIINFLAMMATORY AGENT; TRYPTANTHRIN; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; ENVIRONMENTAL TEMPERATURE; FERMENTATION; HERB; ISATIS TINCTORIA; ISOTOPE DILUTION ASSAY; LIQUID CHROMATOGRAPHY; NONHUMAN; PLANT LEAF; QUANTITATIVE ANALYSIS; WOOD;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRASSICACEAE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUGS, CHINESE HERBAL; HUMANS; PHYTOTHERAPY; PLANT LEAVES; QUINAZOLINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

BRASSICACEAE; ISATIS; ISATIS TINCTORIA;

EID: 3542999961     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-827188     Document Type: Article

References (18)

1. Hurry JB. The woad plant and its dye. Oxford University Press, London: 1930
2. Hamburger M. Isatis tinctoria - From the rediscovery of an ancient medicinal plant towards a novel anti-inflammatory phytopharmaceutical. Phytochemistry Rev 2002; 1: 333-344
3. Danz H, Stoyanova S, Wippich P, Brattström A, Hamburger M. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria. Planta Medica 2001; 67: 411-6
4. Danz H, Stoyanova S, Thomet O, Simon HU, Dannhardt G, Ulbrich H, Hamburger M. Inhibitory activity of tryptanthrin on prostaglandin and leukotriene synthesis. Planta Medica 2002; 68: 875-80
5. 2 synthesis by murine macrophages. Eur J Pharmacol 2000; 407: 197-204
6. Honda G, Tosiriuk V, Tabata M. Isolation of an antidermatophytic, tryptanthrin, from indigo plants, Polygonum tinctorium and Isatis tinctoria. Planta Medica 1980; 38: 275-6
7. Recio MC, Hamburger M, Rios JL. In vivo anti-inflammatory activity of Isatis tinctoria extracts and tryptanthrin. Abstract book, 50th Annual Congress of Society of Medicinal Plant Research 2002 Canigueral S, editor. Carlet (Valencia): CITA Publicaciones y Documentacion, 2002: p 94
8. Heinemann C, Schliemann-Willers S, Oberthür C, Hamburger M, Elsner P. Prevention of experimentally induced irritant contact dermatitis by Isatis tinctoria and tryptanthrin and its impact on UVB-induced erythema. Planta Medica 2004; 70: 385-90
9. Danz H, Baumann D, Hamburger M. Quantitative determination of the dual COX-2/5-LOX inhibitor tryptanthrin in Isatis tinctoria by ESI-LC-MS. Planta Medica 2002; 68: 152-7
10. Benthin B, Danz H, Hamburger M. Pressurized liquid extraction (PLE) of medicinal plants. J Chromatogr A 1999; 837: 211-9
11. Oberthür C, Hoffmann B, Hamburger M. Synthesis of d-tryptanthrin. Pharmazie 2002; 57: 586-7
12. Oberthür C, Heinemann C, Elsner P, Benfeldt E, Hamburger M. A comparative study on the skin penetration of pure tryptanthrin and tryptanthrin in Isatis tinctoria extract by dermal microdialysis coupled with isotope dilution ESI-LC-MS. Planta Medica 2003; 69: 385-9
13. Elliott MC, Stowe BB. A novel sulphonated natural indole. Phytochemistry 1970; 9: 1629-32
14. Lockwood GB, Belkhiri A. Glucosinolate spectrum of some Algerian crucifers. Pl Syst Evol 1991; 176: 11-20
15. Fréchard A, Fabre N, Péan C, Montaut S, Fauvel MT, Rollin P, Fouraste I. Novel indole-type glucosinolates from woad (Isatis tinctoria L.). Tetrahedron Lett 2001; 42: 9015-7
16. Oberthür C, Schneider B, Graf H, Hamburger M. The elusive indigo precursors in woad (Isatis tinctoria L.) - Identification of the major indigo precursor, isatan A, and a structure revision of isatan B. Chem Biodiv 2004; 1: 174-82
17. Kokobun T, Edmonds J, John P. Indoxyl derivatives in woad in relation to medieval indigo production. Phytochemistry 1997; 49: 79-87
18. Maugard T, Enaud E, Choisy O, Legoy MD. Identification of an indigo precursor from leaves of Isatis tinctoria (woad). Phytochemistry 2001; 58: 897-904