Functional improvement with low-dose dopaminergic grafts in hemiparkinsonian rats

Neurosurgery

Volumn 55, Issue 2, 2004, Pages 405-412

  Bartlett, Lynsey E ^a   Sadi, Damaso ^a   Lewington, Matthew ^a   Mendez, Ivar ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Dopaminergic grafts; Fetal ventral mesencephalic cells; Neural transplantation; Parkinson's disease; Striatum; Tyrosine hydroxylase

Indexed keywords

DOPAMINE; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK PROTEIN 27; OXIDOPAMINE; TYROSINE 3 MONOOXYGENASE; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CELL COUNT; CELL SURVIVAL; CELL TRANSPLANTATION; CIRCLING BEHAVIOR; CORPUS STRIATUM; DISEASE MODEL; DOPAMINERGIC NERVE CELL; FEMALE; FETUS CELL; GRAFT SURVIVAL; MESENCEPHALON; MICROTOME; NERVE GROWTH; NONHUMAN; OPTICAL DENSITY; PARKINSON DISEASE; PARKINSONISM; PRIORITY JOURNAL; RAT; RAT STRAIN; SCORING SYSTEM; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 3542999875     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.neu.0000129550.31643.54     Document Type: Article

References (45)

1. Apostolides C, Sanford E, Hong M, Mendez I: Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience 83:363-372, 1998.
2. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW: Cytotoxicity of microglia. Glia 7:111-118, 1993.
3. Barker RA, Dunnett SB, Faissner A, Fawcett JW: The time course of loss of dopaminergic neurons and the gliotic reaction surrounding grafts of embryonic mesencephalon in the striatum. Exp Neurol 141:79-93, 1996.
4. Bignami A, Dahl D: The astroglial response to stabbing: Immunofluorescence studies with antibodies to astrocyte-specific protein (GFA) in mammalian and submammalian vertebrates. Neuropathol Appl Neurobiol 2:99-110, 1976.
5. Bignami A, Dahl D: Specificity of the glial fibrillary acidic protein for astroglia. J Histochem Cytochem 25:466-469, 1977.
6. Björklund L: Intracranial and intraocular grafting of fetal ventral mesencephalic and striatal tissues: Neuronal survival and nerve growth characteristics. Stockholm, Karolinska Institute, 1998 (thesis).
7. Björklund A, Stenevi U, Schmidt RH, Dunnett SB, Gage FH: Intracerebral grafting of neuronal cell suspensions: Part I - Introduction and general methods of preparation. Acta Physiol Scand Suppl 522:1-7, 1983.
8. Bolam JP, Freund TF, Björklund A, Dunnett SB, Smith AD: Synaptic input and local output of dopaminergic neurons in grafts that functionally reinnervate the host striatum. Exp Brain Res 68:131-146, 1987.
9. Brundin P, Björklund A: Survival, growth and function of dopaminergic neurons grafted to the brain, in Seil J, Herbet E, Carlson BM (eds): Progress in Brain Research. Amsterdam, Elsevier, 1987, vol 71, pp 293-308.
10. Brundin P, Barbin G, Strecker RE, Isacson O, Prochiantz A, Björklund A: Survival and function of dissociated rat dopamine neurons grafted at different developmental stages or after being cultured in vitro. Dev Brain Res 39:233-243, 1988.
11. Brundin P, Dunnett S, Björklund A, Nikkhah G: Transplanted dopaminergic neurons: More or less? Nat Med 7:512-513, 2001.
12. Brundin P, Isacson O, Björklund A: Monitoring of cell viability in suspension of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res 331:251-259, 1985.
13. Brundin P, Karlsson J, Emgard M, Schierle GS, Hansson O, Petersen A, Castilho RF: Improving the survival of grafted dopaminergic neurons: A review over current approaches. Cell Transplant 9:179-195, 2000.
14. Collier TJ, Sortwell CE, Daley BF: Diminished viability, growth, and behavioral efficacy of fetal dopamine neuron grafts in aging rats with long-term dopamine depletion: An argument for neurotrophic supplementation. J Neurosci 19:5563-5573, 1999.
15. Doucet G, Brundin P, Descarries L, Björklund A: Effect of prior dopamine denervation on survival and fiber outgrowth from intrastriatal fetal mesencephalic grafts. Eur J Neurosci 2:279-290, 1990.
16. Emmett CJ, Jaques BW, Seeley PJ: Microtransplantation of neural cells into adult rat brain. Neuroscience 38:213-222, 1990.
17. Freed CR, Breeze RE, Fahn S: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 345:146-147, 2001.
18. Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, Kao R, Dillon S, Winfield H, Culver S, Trojanowski JQ, Eidelberg D, Fahn S: Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 344:710-719, 2001.
19. Freeman TB, Olanow CW, Hauser RA, Nauert GM, Smith DA, Borlongan CV, Sanberg PR, Holt DA, Kordower JH, Vingerhoets FJ, Snow BJ, Calne D, Gauger LL: Bilateral fetal nigral transplantation into the postcommissural putamen in Parkinson's disease. Ann Neurol 38:379-388, 1995.
20. Freund TF, Bolam JP, Björklund A, Stenevi U, Dunnett SB, Powell JF, Smith AD: Efferent synaptic connections of grafted dopaminergic neurons reinnervating the host neostriatum: A tyrosine hydroxylase immunocytochemical study. J Neurosci 5:603-616, 1985.
21. Gerhardt GA, Cass WA, Yi A, Zhang Z, Gash DM: Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys. J Neurochem 80:168-177, 2002.
22. Gundersen HJG, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 147:229-263, 1987.
23. Hagell P, Brundin P: Cell survival and clinical outcome following intrastriatal transplantation in Parkinson disease. J Neuropathol Exp Neurol 60:741-752, 2001.
24. Herman JP, Choulli K, Geffard M, Nadaud D, Taghzouti K, Le Moal M: Reinnervation of the nucleus accumbens and frontal cortex of the rat by dopaminergic grafts and effects on hoarding behavior. Brain Res 372:210-216, 1986.
25. Isacson O, Björklund L, Pemaute RS: Parkinson's disease: Interpretations of transplantation study are erroneous. Nat Neurosci 4:553, 2001.
26. Kordower JH, Freeman TB, Snow BJ, Vingerhoets FJ, Mufson EJ, Sanberg PR, Hauser RA, Smith DA, Nauert GM, Perl DP, Olanow CW: Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N Engl J Med 332:1118-1124, 1995.
27. Krueger-Naug AMR, Plumier JC, Hopkins DA, Currie RW: Hsp27 in the nervous system: Expression in pathophysiology and in the aging brain, in Arrigo AP, Muller WEG (eds): Progress in Molecular and Subcellular Biology. Berlin, Springer-Verlag, 2002, vol 28, pp 235-251.
28. Mahalik TJ, Finger TE, Strömberg I, Olson L: Substantia nigra transplants into denervated striatum of the rat: Ultrastructure of graft and host interconnections. J Comp Neurol 260:60-70, 1985.
29. Mehta V, Hong M, Spears J, Mendez I: Enhancement of graft survival and sensorimotor behavioural recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor. J Neurosurg 88:1088-1095, 1998.
30. Mendez I, Hong M: Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: A tracer study using fluorogold and horseradish peroxidase. Brain Res 778:194-205, 1997.
31. Mendez I, Hong M, Smith S, Dagher A, Desrosiers J: Neural transplantation cannula and microinjector system: Experimental and clinical experience. J Neurosurg 92:493-499, 2000.
32. Mendez I, Sadi D, Hong M: Reconstruction of the nigrostriatal pathway by simultaneous intrastriatal and intranigral dopaminergic transplants. J Neurosci 16:7216-7227, 1996.
33. 18F]dopa PET findings in early Parkinson's disease. J Neurol Neurosurg Psychiatry 59:597-600, 1995.
34. Nakao N, Frodl EM, Duan W, Widner H, Brundin P: Lazaroids improve the survival of grafted rat embryonic dopamine neurons. Proc Natl Acad Sci U S A 91:12408-12412, 1994.
35. Nikkhah G, Cunningham MG, Jödicke A, Knappe U, Björklund A: Improved graft survival and striatal reinnervation by microtransplantation of fetal nigral cell suspensions in the rat Parkinson model. Brain Res 633:133-143, 1994.
36. Nikkhah G, Duan WM, Knappe U, Jödicke A, Björklund A: Restoration of complex sensorimotor behavior and skilled forelimb use by a modified nigral cell suspension transplantation approach in the rat Parkinson model. Neuroscience 56:33-43, 1993.
37. Olanow CW, Goetz C, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, Freeman TB: A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 54:403-414, 2003.
38. Peschanski M, Defer G, N'Guyen JP, Ricolfi F, Monfort JC, Remy P, Geny C, Samson Y, Hantraye P, Jeny R, Gaston A, Kéravel Y, Degos JD, Cesaro P: Bilateral motor improvement and alteration of L-dopa effect in two patients with Parkinson's disease following intrastriatal transplantation of fetal ventral mesencephalon. Brain 117:487-499, 1994.
39. Plumier JC, Hopkins DA, Robertson HA, Currie RW: Constitutive expression of the 27-kDa heat shock protein (Hsp27) in sensory and motor neurons of the rat nervous system. J Comp Neurol 384:409-428, 1997.
40. Rezaie P, Patel K, Male DK: Microglia in the human fetal spinal cord: Patterns of distribution, morphology and phenotype. Brain Res Dev Brain Res 115:71-81, 1999.
41. Rioux L, Gaudin DP, Bui LK, Gregoire L, DiPaolo T, Bedard PJ: Correlation of functional recovery after a 6-hydroxydopamine lesion with survival of grafted fetal neurons and release of dopamine in the striatum of the rat. Neuroscience 40:123-131, 1991.
42. 18F]6-L-fluorodopa studies in two patients with putaminal implants. Ann Neurol 31:166-173, 1992.
43. Schmidt RH, Björklund A, Stenevi U, Dunnett SB, Gage FH: Intracerebral grafting of neuronal cell suspensions: Part III - Activity of intrastriatal nigral suspension implants as assessed by measurements of dopamine synthesis and metabolism. Acta Physiol Scand 522:19-28, 1983.
44. Sterio DC: The unbiased estimation of number and sizes of arbitrary particles using the dissector. J Microsc 134:127-136, 1984.
45. Streit WJ: Microglial cells, in Kettenman H, Ransom BR (eds): Neuroglia. Oxford, Oxford University Press, 1995, pp 85-96.